... LIN-12/NOTCH Hydroxyurea Cell-cell signaling is a common mode of cell fate specification in animal development. In many cases, signals must act at defined developmental stages or steps in a cell lineage, so a cell’s ability to select a specific fate in response to particular extracellular...

... MB structure. The expression patterns of 19 GAL4 enhancer-trap strains that mark various subsets of MB cells revealed overlapping cell types in all four of the MBNb lineages. Partial ablation of MBNbs using hydroxyurea showed that each of the four neuroblasts autonomously generates the entire...

... throughout the second and third instars, resulting in a small clone of twist-expressing cells at puparium formation. Treatment with a DNA-synthesis inhibitor, hydroxyurea (HU), ablates these cells if applied during S-phase of their replication cycle. We ablated twist -expressing lineages in the larva...