... the arrested state. Although a steroid hormone pathway regulates the entry decision into C. elegans dauer diapause, its role in the exit decision is less clear. A complication to understanding steroid hormonal regulation of dauer has been the peculiar fact that steroid hormone mutants such as daf-9 form...

...Jennifer M. Worthen; Maria V. Yamburenko; Jeewoo Lim; Zachary L. Nimchuk; Joseph J. Kieber; G. Eric Schaller ABSTRACT Cytokinins are plant hormones with crucial roles in growth and development. Although cytokinin signaling is well characterized in the model dicot Arabidopsis , we are only beginning...

... in the pituitary. Thus, in Insm1 mutant mice, hormones characteristic of the different pituitary cell types (thyroid-stimulating hormone, follicle-stimulating hormone, melanocyte-stimulating hormone, adrenocorticotrope hormone, growth hormone and prolactin) are absent or produced at markedly reduced levels...

... that regulate AMP specification. Here, we demonstrate that Broad (Br)-mediated hormone signaling regulates AMP specification. Br is highly expressed in AMPs temporally during the larva-pupa transition stage, and br loss of function blocks AMP differentiation. Furthermore, Br is required for AMPs to develop...

... and writing of the histone code involved in hormone-stimulated gene programming, including receptor-binding motifs, SET methyltransferase, HMG and PHD domains. The genes encoding MLL2 and MLL3 arose from a common ancestor. Phylogenetic analyses reveal that the ancestral gene underwent a fission event in some...

... receptor fused to the DNA-binding domain of yeast GAL4. When combined with a GAL4-responsive reporter gene, the fusion proteins show tissue- and stage-specific patterns of activation. We show that these responses accurately reflect the presence of endogenous and exogenously added hormone, and that they can...

... patterns. We find that the ncr genes function in a hormonal branch of the dauer formation pathway upstream of daf-9 and daf-12 , which encode a cytochrome P450 enzyme and a nuclear hormone receptor, respectively. ncr-1 is expressed broadly in tissues with high levels of cholesterol, whereas expression...

... to steroidogenic hydroxylases and its cognate nuclear receptor daf-12 , implying organism-wide coordination by lipophilic hormones. Accordingly, here we show that daf-9(+) works cell non-autonomously to bypass diapause, and promote gonadal outgrowth. Among daf-9 -expressing cells, the hypodermis is most visibly...

...Julie Gates; Geanette Lam; José A. Ortiz; Régine Losson; Carl S. Thummel Pulses of the steroid hormone ecdysone trigger the major developmental transitions in Drosophila , including molting and puparium formation. The ecdysone signal is transduced by the EcR/USP nuclear receptor heterodimer...

...Heather Perry Gardner; George K. Belka; Gerald B. W. Wertheim; Jennifer L. Hartman; Seung I. Ha; Phyllis A. Gimotty; Sandra T. Marquis; Lewis A. Chodosh ABSTRACT The steroid hormones 17β;-estradiol and progesterone play a central role in the pathogenesis of breast cancer and regulate key phases...

... of the imaginal primordia to differentiate properly during pupal development, sug- gesting that hdc may be involved in hormonal responsive- ness during metamorphosis. * Author for correspondence (email: [email protected] ) 23 08 1995 © 1995 by Company of Biologists 1995...