... activity remains unknown. Here, we study the role of Meis in axial skeleton formation and its relationship to the RA pathway in mice. Meis elimination in the paraxial mesoderm produces anterior homeotic transformations and rib mis-patterning associated to alterations of the hypaxial myotome. Although...

[email protected] ) 6 6 2008 © 2008. 2008 Cdx Overexpression Homeotic transformation Hox Mouse Organization of the developing head-tail axis of the mouse embryo is mediated, at least in part, by the expression patterns of the 39 Hox genes. Each Hox gene exerts its main effect...

... ). In Mll1 -deficient mouse embryos, Hox gene expression is not properly maintained, leading to anterior homeotic transformations of segmental identities and defects during hematopoesis( Yagi et al., 1998 ; Yu et al., 1998 ; Yu et al., 1995 ). More recently, based on genetic analysis in zebrafish, a TrxG...

... motif for homeotic transformations in adult Drosophila . By ectopic overexpression, the head structures of the fly can be transformed into structures of the second thoracic segment, such as antenna into second leg, head capsule into thorax (notum) and eye into wing. We found that the YPWM motif...

... cofactors for Distal-less. * Author for correspondence (e-mail: [email protected] ) 05 11 1999 © 2000 by Company of Biologists 2000 Distal-less homothorax Antennapedia spalt Antenna Leg Limb Homeotic transformation The similar developmental potentials...

... mutant embryos results in homeotic transformations and aberrant morphogenesis. Here we examine the role of exd in adult development by using genetic mosaics and a hypomorphic exd allele caused by a point mutation in the homeodomain. exd continues to be essential for the specification of segmental...

...Allan Peter Davis; Mario R. Capecchi ABSTRACT Using gene targeting, we have created mice with a disruption in the homeobox-containing gene hoxd-11 . Homozygous mutants are viable and the only outwardly apparent abnormality is male infertility. Skeletons of mutant mice show a homeotic transformation...

.... The dens and the superior facets are deleted, and the axis shows ‘atlas-like’ characteristics. An unexpected observation is that different parts of the same vertebra are differentially affected by the loss of Hoxd-3 function. Some parts are deleted, others are homeotically transformed to more anterior...

... 08 1993 © 1993 by Company of Biologists 1993 Drosophila bric à brac limb development imaginal discs homeotic transformation BTB domain Drosophila melanogaster has been used extensively as a model system for the study of development and pattern formation. Both...

...Deborah J. Andrew ABSTRACT In specific genetic backgrounds, a mutation in the tuh-3 gene results in the homeotic transformation of head structures to either leg disc derivatives or structures normally found in the extreme posterior end of wild-type animals. The origins of the homeotic structures...

... within the BX-C of a DNA fragment of 17 kb containing pbx + inserted into the Ubx area. In addition to the dominant phenotype, the Cbx 1 mutation produces a set of recessive homeotic transformations that we show are characteristic of the Ubx mutations. We present evidence that the dominant...