... at the adaxial base of the fourth leaf primordium. We cloned the ABL1 and ABL2 genes of rice by mapping their chromosomal positions. ABL1 encodes OsHK6, a histidine kinase, and ABL2 encodes a transcription factor, OSHB3 (Class III homeodomain leucine zipper). Expression analyses of these mutant genes as well...

...Chris Q. Doe; Stefan Thor ABSTRACT Drosophila nervous system development progresses through a series of well-characterized steps in which homeodomain transcription factors (HDTFs) play key roles during most, if not all, phases. Strikingly, although some HDTFs have only one role, many others...

... conditions. Ingenuity Pathway Analysis software from Qiagen was used to identify regulatory pathway enrichment. HOX proteins bind DNA through a highly conserved 60 amino acid region called the homeodomain ( McGinnis et al., 1984 ). HOX proteins alone show limited DNA-binding ability, but they gain...

...Simon Scofield; Alexander Murison; Angharad Jones; John Fozard; Mitsuhiro Aida; Leah R. Band; Malcolm Bennett; James A. H. Murray ABSTRACT The Arabidopsis homeodomain transcription factor SHOOT MERISTEMLESS (STM) is crucial for shoot apical meristem (SAM) function, yet the components and structure...

... of Drosophila sensory neurons is diversified through a series of suppressive transcriptional interactions involving the POU domain transcription factors Pdm1 (Nubbin) and Pdm2, the homeodomain transcription factor Cut, and the transcriptional regulators Scalloped and Vestigial. Pdm1 and Pdm2 are expressed...

...René Rezsohazy; Andrew J. Saurin; Corinne Maurel-Zaffran; Yacine Graba Hox genes encode homeodomain transcription factors that control morphogenesis and have established functions in development and evolution. Hox proteins have remained enigmatic with regard to the molecular mechanisms that endow...

..., dorsal-ventral and medial-lateral axes. Wnt and several Hox genes are expressed at the posterior pole, whereas Wnt inhibitory genes, Fgf inhibitory genes, and prep , which encodes a TALE-family homeodomain protein, are expressed at the anterior pole. We found that Smed-pbx ( pbx for short), which encodes...

...Brian W. Busser; Leila Shokri; Savina A. Jaeger; Stephen S. Gisselbrecht; Aditi Singhania; Michael F. Berger; Bo Zhou; Martha L. Bulyk; Alan M. Michelson A subfamily of Drosophila homeodomain (HD) transcription factors (TFs) controls the identities of individual muscle founder cells (FCs). However...

... on the homeodomain-containing transcription factor Nanog. Compared with other pluripotency-associated genes, however, Nanog shows relatively low sequence conservation. Here, we investigated whether Nanog orthologs have the capacity to orchestrate establishment of pluripotency in Nanog –/– somatic cells. Mammalian...

... tissues, but little is known about how small differences in the concentration of extracellular signals are translated into robust patterning output in responding cells. We have examined the activity of homeodomain proteins, which are presumed to operate downstream of graded Shh signaling in neural...

... mutants. One of these corresponds to the LIM class homeodomain (HD) protein CEH-14/Lhx3, and the other two correspond to Paired-like HD proteins CEH-10/Chx10 and CEH-17/Phox2. Whereas CEH-14 is required for ALA-specific gene expression throughout development, the Prd-like proteins display complementary...

...Ulrika Marklund; Emil M. Hansson; Erik Sundström; Martin Hrabé de Angelis; Gerhard K. H. Przemeck; Urban Lendahl; Jonas Muhr; Johan Ericson Homeodomain (HD) transcription factors and components of the Notch pathway [Delta1 (Dll1), Jagged1 (Jag1) and the Fringe (Fng) proteins] are expressed...

...David A. Elliott; Mark J. Solloway; Natalie Wise; Christine Biben; Mauro W. Costa; Milena B. Furtado; Martin Lange; Sally Dunwoodie; Richard P. Harvey Homeodomain factor Nkx2-5 is a central component of the transcription factor network that guides cardiac development; in humans, mutations in NKX2.5...

... to study mechanisms coordinating these events at single cell resolution. We have identified an HMX homeodomain protein MLS-2 in a screen for factors required for M lineage patterning. The MLS-2 protein is present in nuclei of undifferentiated cells in the early M lineage and in a subset of head neurons...

... and patterning. To understand how Pax6 coordinates these diverse effects at the molecular level, we examined the role of distinct DNA-binding domains of Pax6, the homeodomain (HD), the paired domain (PD) and its splice variant (5a), using loss- and gain-of-function approaches. Here we show that the PD...

... for Antennapedia superclass homeodomain proteins. Chromatin immunoprecipitation and mutagenesis experiments indicate that the GCCG sites are direct targets of BMP restricted Smads. Intriguingly, however, these sites are not sufficient for BMP responsiveness in mouse embryos; the TTAATT sequence is also required...

..., CA 94720-3140, USA 4 8 2003 © 2003. 2003 Axon guidance Homeodomain Transcriptional repressor Evx Hb9 Grunge Atrophin Groucho Eve Nervous system The homeobox-containing gene even skipped ( eve ) was first identified as a segmentation gene based on the cuticular...

... developmental function. † Author for correspondence (e-mail: [email protected] ) * Present address: Scully, Scott, Murphy & Presser, 400 Garden City Plaza, Garden City, New York, NY 11530, USA 20 5 2003 © 2003. 2003 Homeodomain KNOX Shoot meristem knotted1 GFP...

... the characterization of the mutant Pph13 hazy . Pph13 is a homeodomain transcription factor expressed only in photoreceptor cells. Pph13 expression correlates with the differentiation and not specification of photoreceptor cells. In agreement with its expression profile, we find Pph13 is required for both rhabdomere...

...Savita Ayyar; Jianqiao Jiang; Anna Collu; Helen White-Cooper; Robert A. H. White We have investigated the role of TGIF, a TALE-class homeodomain transcription factor, in Drosophila development. In vertebrates, TGIF has been implicated, by in vitro analysis, in several pathways, most notably...