... homeobox gene that is expressed almost exclusively in human embryos during preimplantation development. We previously identified a novel transcription start site for the predicted human LEUTX gene based on the transcriptional analysis of human preimplantation embryos. The novel variant encodes a protein...

... not shown). * Author for correspondence (e-mail: [email protected] ) 7 6 2004 © 2004. 2004 Mouse Bone Mandible Patterning Neural crest cell Homeobox gene Craniofacial morphogenesis is orchestrated through a specific array of transcription factors, expressed...

... phenotypes, the glycinergic andγ-aminobutyric acid (GABA)ergic amacrine cells constitute two major subpopulations. To date, the molecular mechanisms governing the specification of subtype identity of amacrine cells remain elusive. We report here that during mouse development, the Barhl2 homeobox gene...

... and neuronal cells, as well as outgrowth and restructuring of the otocyst to form a complex labyrinth. Hmx2 , a member of the Hmx homeobox gene family, is coexpressed with Hmx3 in the dorsolateral otic epithelium. Targeted disruption of Hmx2 in mice demonstrates the temporal and spatial involvement of Hmx2...

..., which we propose to be the underlying cause of the subsequent malformations. *Author for correspondence (e-mail: [email protected] ) 18 7 2001 © 2001. 2001 Cleft face Homeobox gene Craniofacial development Apoptosis Mouse Aristaless-related genes Cephalic neural crest...

... expression Evolution Homeobox gene orthodenticle engrailed Pristina leidyi How can embryogenesis, regeneration and fission converge on a common endpoint (the adult morphology) from drastically different starting points (a one-celled egg versus part of a multicellular adult body)? Post...

... Transcription Homeobox gene Wnt signaling Regulation C. elegans sop-3 Cell fate specification during multicellular development occurs by a progressive series of changes in cell transcriptional states. Through such programs of gene transcriptional regulation, differentiated cells of defined...

...Thomas R. Bürglin; Gary Ruvkun ABSTRACT Caenorhabditis elegans has three POU homeobox genes, unc-86, ceh-6 and ceh-18. ceh-6 is the ortholog of vertebrate Brn1, Brn2, SCIP/Oct6 and Brn4 and fly Cf1a/drifter/ventral veinless . Comparison of C. elegans and C. briggsae CEH-6 shows that it is highly...

... have been identified. It is currently unclear, however, how the differential capacity to respond to these cues is transcriptionally implemented in distinct neuronal subtypes. Here, we characterise a C. elegans paired-like homeobox gene, CePhox2 / ceh-17 , expressed in five head neurons, ALA and the 4...

... by Company of Biologists 2000 knotted1 Maize Meristem Embryo Homeobox gene The diversity of plant form relies on events that take place in meristems. Meristems are organized groups of self-renewing cells that produce the organs of the plant. The type of organs produced by a meristem...

... implicated the homeobox genes Pax6 and Nkx2 . 2 in the early divergence of the transcriptional programme of hindbrain somatic and visceral motor neuronal differentiation. We provide genetic evidence that the paired-like homeodomain protein Phox2b is required for the formation of all branchial and visceral...

...Tetsuya Kojima; Makoto Sato; Kaoru Saigo ABSTRACT Here, we show that BarH1 and BarH2 , a pair of Bar homeobox genes, play essential roles in the formation and specification of the distal leg segments of Drosophila . In early third instar, juxtaposition of Bar-positive and Bar-negative tissues...

...Henning Brohmann; Krzysztof Jagla; Carmen Birchmeier ABSTRACT The homeobox gene Lbx1 is expressed in migrating hypaxial muscle precursor cells during development. These precursors delaminate from the lateral edge of the dermomyotome and form distinct streams that migrate over large distances, using...

... and Anatomy, University of Arizona College of Medicine, 1601 N. Campbell Avenue, Tucson, AZ 85724, USA (e-mail: [email protected] ) 08 10 1999 08 12 1999 © 1999 by Company of Biologists 1999 Left/right axis Spleen Nkx2-5 Homeobox gene tinman Polysplenia Vertebrate...

...Makoto Tanaka; Stephanie Burns Wechsler; Ike W. Lee; Naohito Yamasaki; Joel A. Lawitts; Seigo Izumo The murine homeobox gene Csx/Nkx2 . 5 is an evolutionarily highly conserved gene related to the Drosophila tinman gene, which specifies cardiac and visceral mesoderm. Since Csx/Nkx2 . 5 plays...

... plate. How these signals get transmitted to the forming organs is not known. A candidate mediator in mouse, frog and zebrafish embryos is the homeobox gene Pitx2 . It is asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube. Localized Pitx2 expression continues...

...Naoyuki Takuma; Hui Z. Sheng; Yasuhide Furuta; Jerrold M. Ward; Kamal Sharma; Brigid L. M. Hogan; Samuel L. Pfaff; Heiner Westphal; Shioko Kimura; Kathleen A. Mahon ABSTRACT Targeted disruption of the homeobox gene T/ebp ( Nkx 2.1, Ttf 1, Titf 1) in mice results in ablation of the pituitary...

...Derk ten Berge; Antje Brouwer; Jeroen Korving; James F. Martin; Frits Meijlink ABSTRACT Prx1 and Prx2 are closely related paired-class homeobox genes that are expressed in very similar patterns predominantly in mesenchyme. Prx1 loss-of-function mutants show skeletal defects in skull, limbs...

... for the specification of adaxial cell identity within leaves and leaflike lateral organs. Lbl1 is also required for the lateral propagation of leaf founder cell recruitment, and plays a direct or indirect role in the downregulation of the homeobox gene, knotted1 , during leaf development. Our results suggest...

... process are poorly defined. Tlx-2 is a homeobox gene expressed in the primitive streak of mouse embryos. Exogenous BMP-2 rapidly activates Tlx-2 expression in the epiblast of E6.5 embryos. A Tlx-2 promoter element responds to BMP-2 signals in P19 cells, and this response is mediated by BMP type I...