...Douglas B. Menke; Catherine Guenther; David M. Kingsley The Tbx4 transcription factor is crucial for normal hindlimb and vascular development, yet little is known about how its highly conserved expression patterns are generated. We have used comparative genomics and functional scanning...

...L. A. Naiche; Virginia E. Papaioannou Tbx4 is a crucial gene in the initiation of hindlimb development and has been reported as a determinant of hindlimb identity and a presumptive direct regulator of Fgf10 in the limb. Using a conditional allele of Tbx4 , we have ablated Tbx4 function before...

... in vivo. * Author for correspondence (e-mail: [email protected] ) 13 2 2006 © 2006. 2006 Isl1 Bmp Tbx2 Tbx3 Heart Hindlimb The frequency of human congenital diseases presenting with heart and limb anomalies is at minimum 1 out of 5000 live births( Wilson...

... secretes an inhibitory factor, preventing RA-induced or already established Hoxb-8 expression in the cells immediately underneath the AER. Consistent with a role for Hoxb-8 in positioning of the forelimb ZPA, Hoxb-8 expression is not seen in RA-induced duplications at the anterior of the hindlimb. However...

...Barbara J. Fredette; Jason Miller and Barbara Ranscht ABSTRACT As spinal motor neurons project to their hindlimb targets, their growth cones avoid particular regions along their pathway. T-cadherin is discretely distributed in the avoided caudal sclerotome and on extrasynaptic muscle surfaces (B. J...