... timing. Here, we demonstrate that sea-2 , which encodes a zinc-finger protein, controls developmental timing in C. elegans larvae by regulating expression of the heterochronic gene lin-28 at the post-transcriptional level. lin-28 is also essential for the autosomal signal element (ASE) function of sea-2...

...Anita S.-R. Pepper; Jill E. McCane; Kevin Kemper; Denise Au Yeung; Rosalind C. Lee; Victor Ambros; Eric G. Moss The succession of developmental events in the C. elegans larva is governed by the heterochronic genes. When mutated, these genes cause either precocious or retarded developmental...

... determination heterochronic genes Multicellular development involves numerous regulatory events whereby multipotent cells adopt specific fates. The precise mechanisms by which cells are endowed with a defined set of potential fates, and the regulatory steps by which those cells are directed toward...

...Gary Ruvkun; Bruce Wightman; Thomas Bürglin; Prema Arasu The heterochronic gene lin-14 controls the temporal sequence of developmental events in the C. elegans postembryonic cell lineage. It encodes a nuclear protein that is normally present in most somatic cells of late embryos and LI larvae...