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Keywords: hedgehog
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Journal Articles
Journal: Development
Development (2022) 149 (6): dev200159.
Published: 16 March 2022
...Nicole Roberto; Isabelle Becam; Anne Plessis; Robert A. Holmgren ABSTRACT Morphogen gradients need to be robust, but may also need to be tailored for specific tissues. Often this type of regulation is carried out by negative regulators and negative feedback loops. In the Hedgehog (Hh) pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (22): dev199630.
Published: 22 November 2021
... the activation of the EGFR effector, ERK. Also, we found that loss of ben , but not the JNK kinase hemipterous , resulted in an upregulation of hedgehog signaling, increased proliferation and increased niche competition. Lastly, we demonstrate that the hypercompetition phenotype caused by loss of ben...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (19): dev199585.
Published: 5 October 2021
...Hsiao-Fan Lo; Mingi Hong; Henrietta Szutorisz; Yasmin L. Hurd; Robert S. Krauss ABSTRACT Many developmental disorders are thought to arise from an interaction between genetic and environmental risk factors. The Hedgehog (HH) signaling pathway regulates myriad developmental processes, and pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (9): dev195552.
Published: 29 April 2021
...Emily K. Ho; Tim Stearns ABSTRACT The mechanisms of vertebrate Hedgehog signaling are linked to the biology of the primary cilium, an antenna-like organelle that projects from the surface of most vertebrate cell types. Although the advantages of restricting signal transduction to cilia are often...
Journal Articles
Journal: Development
Development (2021) 148 (5): dev191791.
Published: 9 March 2021
...Tanvi Gore; Tamás Matusek; Gisela D'Angelo; Cécile Giordano; Thomas Tognacci; Laurence Lavenant-Staccini; Catherine Rabouille; Pascal P. Thérond ABSTRACT The Hedgehog (Hh) morphogen gradient is required for patterning during metazoan development, yet the mechanisms involved in Hh apical...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (23): dev189076.
Published: 14 December 2020
...Martha L. Echevarría-Andino; Benjamin L. Allen ABSTRACT The Hedgehog (HH) pathway controls multiple aspects of craniofacial development. HH ligands signal through the canonical receptor PTCH1, and three co-receptors: GAS1, CDON and BOC. Together, these co-receptors are required during embryogenesis...
Includes: Supplementary data
Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2020) 147 (22): dev195974.
Published: 17 November 2020
...Ryo Hatori; Thomas B. Kornberg ABSTRACT Hedgehog (Hh) is an evolutionarily conserved signaling protein that has essential roles in animal development and homeostasis. We investigated Hh signaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal air sac...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184689.
Published: 28 April 2020
... in adaxial slow precursors, thereby initiating trunk myogenesis. After gastrulation, when similar muscle cell populations in the post-anal tail are generated from tailbud, declining Fgf signalling is less effective at initiating adaxial myogenesis, which is instead initiated by Hedgehog signalling from...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (22): dev182154.
Published: 25 November 2019
... work is properly attributed. Summary: This Review summarizes the spatial and temporal gene regulatory patterning systems that produce the diversity and organization of neurons in the vertebrate spinal cord. Gene regulatory network Hedgehog Neural tube Neurogenesis Neuronal diversity...
Journal Articles
Journal: Development
Development (2019) 146 (8): dev176933.
Published: 25 April 2019
.../ Summary:   Drosophila ocellar cells perform the biological equivalent of a mathematical logarithmic transformation by decoding a morphogen gradient to produce a wave of differentiating photoreceptors that travels at constant speed throughout the retinal epithelium. Drosophila Hedgehog...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (24): dev166850.
Published: 12 December 2018
...Cecile Giordano; Laurent Ruel; Candice Poux; Pascal Therond ABSTRACT Hedgehog (Hh) is a conserved morphogen that controls cell differentiation and tissue patterning in metazoans. In Drosophila , the Hh signal is transduced from the G protein-coupled receptor Smoothened (Smo) to the cytoplasmic Hh...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (13): dev159947.
Published: 9 July 2018
... signaling interactions between the stroma and nephron progenitor compartment have been proposed to control nephron development. Here, we show that removal of hedgehog intracellular effector smoothened ( Smo -deficient mutants) in the cortical stroma results in an abnormal renal capsule, and an expanded...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev164236.
Published: 15 March 2018
...Chengbing Wang; Jia Li; Ken-Ichi Takemaru; Xiaogang Jiang; Guoqiang Xu; Baolin Wang ABSTRACT The primary cilium is a microtubule-based organelle required for Hedgehog (Hh) signaling and consists of a basal body, a ciliary axoneme and a compartment between the first two structures, called...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154054.
Published: 8 January 2018
...Sun-hee Hwang; Kevin A. White; Bandarigoda N. Somatilaka; John M. Shelton; James A. Richardson; Saikat Mukhopadhyay ABSTRACT The role of basal suppression of the sonic hedgehog (Shh) pathway and its interaction with Indian hedgehog (Ihh) signaling during limb/skeletal morphogenesis is not well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (24): 4694–4703.
Published: 15 December 2017
...Guangwei Hu; Guang Li; Hui Wang; Yiquan Wang Correct patterning of left-right (LR) asymmetry is essential during the embryonic development of bilaterians. Hedgehog (Hh) signaling is known to play a role in LR asymmetry development of mouse, chicken and sea urchin embryos by regulating Nodal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (19): 3612–3624.
Published: 1 October 2017
... Hedgehog-containing cytonemes and identified a role for the Hedgehog deployment protein Dispatched in cytoneme stabilization. We demonstrate that Hedgehog and Dispatched colocalize in cytonemes, and that cholesterol-modified Hedgehog acts through Dispatched to increase cytoneme occurrence. Live imaging...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (17): 3134–3144.
Published: 1 September 2017
...Weitao Chen; Hai Huang; Ryo Hatori; Thomas B. Kornberg Morphogen concentration gradients that extend across developmental fields form by dispersion from source cells. In the Drosophila wing disc, Hedgehog (Hh) produced by posterior compartment cells distributes in a concentration gradient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1841–1850.
Published: 15 May 2017
...Matthieu Sanial; Isabelle Bécam; Line Hofmann; Julien Behague; Camilla Argüelles; Vanessa Gourhand; Lucia Bruzzone; Robert A. Holmgren; Anne Plessis Smoothened (SMO) is a G-protein-coupled receptor-related protein required for the transduction of Hedgehog (HH). The HH gradient leads to graded...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (7): 1159–1164.
Published: 1 April 2017
...Andrea G. Schwartz; Leesa M. Galatz; Stavros Thomopoulos The tendon enthesis originates from a specific pool of hedgehog-active Gli1+ progenitor cells that differentiate and produce mineralized fibrocartilage. The current study investigated the regenerative capacity of this cell population...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (20): 3700–3710.
Published: 15 October 2016
... + interstitial progenitors, through the action of Sertoli cell-derived Hedgehog signals, become positive for GLI1. The GLI1 + interstitial cells eventually develop into two cell lineages: steroid-producing fetal Leydig cells and non-steroidogenic cells. The fetal Leydig cell population is restricted by Notch2...
Includes: Supplementary data