... Androgen receptor Heart development National Institutes of Health T32 ES027801 Androgens regulate the development and function of multiple tissues and cell types, including muscle, heart, bone, skin, prostate, reproductive tract and the brain ( Bakker, 2022 ; Cunha et al., 2017...

... involved in trophoblast differentiation. Finally, administration of recombinant human pregnancy-specific glycoprotein 1 (PSG1), a trophoblast-derived secretory glycoprotein, partially corrected placental and embryonic heart defects. This study defines the role of SLC25A1 in heart development by regulating...

... ; Molkentin et al., 1997 ; Singh et al., 2010 ; Zhao et al., 2008 ). Early stages of heart development are highly conserved across vertebrate species ( Poelmann and Gittenberger-de Groot, 2019 ). The initial heart tube is assembled by cardiac progenitors of the first heart field (FHF) that will give...

...://dx.doi.org/10.13039/501100001736 I-1220-363.13/2012 RNA Polymerase II transcription Core promoter Gene expression Nascent transcription Drosophila Heart development Summary: A single DPE core promoter motif in tinman is crucial for developmental gene regulatory networks in vivo...

...Eric J. G. Pollitt; Juliana Sánchez-Posada; Corinna M. Snashall; Christopher J. Derrick; Emily S. Noël ABSTRACT During heart development, the embryonic ventricle becomes enveloped by the epicardium, which adheres to the outer apical surface of the heart. This is concomitant with onset...

... in the ING4- and ING5-deficient state. Our findings suggest that ING4 and ING5 are essential for heart development and promote epicardium and epicardium-derived cell fates and imply mutation of the human ING5 gene as a possible cause of isolated ventricular septal defects. These findings suggest...

... of mouse development. To understand the function of Sall1/4 in heart development, we generated heart-specific Sall1/4 functionally inhibited mice by forced expression of the truncated form of Sall4 (ΔSall4) in the heart. The ΔSall4- overexpression mice exhibited a hypoplastic right ventricle and outflow...

...Agnieszka Nagorska; Andreas Zaucker; Finnlay Lambert; Angus Inman; Sara Toral-Perez; Jan Gorodkin; Yue Wan; Michael Smutny; Karuna Sampath ABSTRACT Heart development is a complex process that requires asymmetric positioning of the heart, cardiac growth and valve morphogenesis. The mechanisms...

... and temporal manner remains unclear. Studies show that Tbx20 directly interacts with the Transducin-like Enhancer of Split (TLE) family of proteins to mediate transcriptional repression. However, a function for the Tbx20-TLE transcriptional repression complex during heart development has yet to be established...

... for epicardium development. Although WT1 is also expressed in coronary endothelial cells (ECs), the abnormal heart development observed in Wt1 knockout mice is mainly attributed to its functions in the epicardium. Here, we have generated an inducible endothelial-specific Wt1 knockout mouse model ( Wt1KO ΔEC...

...-0196-7 Derrick , C. J. , Pollitt , E. J. G. , Sanchez Sevilla Uruchurtu , A. , Hussein , F. , Grierson , A. J. and Noël , E. S. ( 2021 ). Lamb1a regulates atrial growth by limiting second heart field addition during zebrafish heart development . Development 148...

..., respectively). (E) Western blot analysis of ATF4 ( n =3). Data are mean±s.e.m. * P <0.05 on two-tailed unpaired Student's t -test. Although mitochondrial abnormalities can cause heart developmental defects, the importance of mitochondrial quality control for prenatal heart development has...

...Christopher J. Derrick; Eric J. G. Pollitt; Ashley Sanchez Sevilla Uruchurtu; Farah Hussein; Andrew J. Grierson; Emily S. Noël ABSTRACT During early vertebrate heart development, the heart transitions from a linear tube to a complex asymmetric structure, a morphogenetic process that occurs...

... and nuclear mechanisms. It is also crucial for the sequential activation of a series of later-stage cardiac genes for cardiac fate commitment. Therefore, non-coding RNAs, including HBL1 and miR-1, and PRC2 function together to fine-tune early human heart development from PSCs. Our findings support...

...Mingjie Xu; Jie Yao; Yingchao Shi; Huijuan Yi; Wukui Zhao; Xinhua Lin; Zhongzhou Yang ABSTRACT Mammalian heart development relies on cardiomyocyte mitochondrial maturation and metabolism. Embryonic cardiomyocytes make a metabolic shift from anaerobic glycolysis to oxidative metabolism by mid...

... morphogenesis of a linear tube. This Review explores how cardiac extracellular matrix composition changes to support specific processes during heart morphogenesis. Cardiac morphogenesis Extracellular matrix Heart development Heart regeneration Heart development is a highly complex process...

... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...

... in the cardiac regeneration response to injury. Cardiac neural crest cells Cardiac specification Myocardium Heart development Cardiac regeneration Neural crest cells (NCCs) are a multipotential population of cells unique to vertebrates that arise after delamination from the dorsal-most aspect...

... and plays a key role in heart development . Dev. Biol.   217 , 42 - 53 . 10.1006/dbio.1999.9534 Auman , H. J. , Coleman , H. , Riley , H. E. , Olale , F. , Tsai , H.-J. and Yelon , D. ( 2007 ). Functional modulation of cardiac form through regionally confined cell shape...

...Andrew Holowiecki; Kelsey Linstrum; Padmapriyadarshini Ravisankar; Kashish Chetal; Nathan Salomonis; Joshua S. Waxman ABSTRACT Vertebrate heart development requires the integration of temporally distinct differentiating progenitors. However, few signals are understood that restrict the size...