... normal OFT development. * Author for correspondence (e-mail: [email protected] ) 20 3 2006 © 2006. 2006 Connexin 43 (Gja1) Cardiac neural crest Neural tube Outflow tract Heart defect Mouse Connexins are membrane-spanning proteins that make up gap...

... orifice and valve ( Fig. 2E ). In the null embryo, both tricuspid and mitral valves are connected to the left ventricle ( Fig. 2F ). Fig. 2. Congenital heart defects of TGFβ2-null mice. Transverse heart sections at the arterial (A,B), outflow tract (C,D) and atrioventricular valve (E,F) levels...

... may partially complement the Cx43 deletion. Both the Cx43 knockout and the CMV43 trans-genic mice exhibit heart defects associated with malformations in the conotruncus, a region of the heart in which neural crest derivatives are known to have important roles during development. Together with our...