...-mail: [email protected] ) 20 3 2006 © 2006. 2006 Connexin 43 (Gja1) Cardiac neural crest Neural tube Outflow tract Heart defect Mouse Connexins are membrane-spanning proteins that make up gap junctions -intercellular channels that allow ions, second messengers...

... targeting heart defect skeletal defect epithelial-mesenchymal interaction mouse knockout TGFβ2 is a member of the highly conserved TGFβ super gene family that consists of more than thirty ligand proteins (reviewed by Kingsley, 1994 ). Members of this family represent structurally similar, yet...

... may partially complement the Cx43 deletion. Both the Cx43 knockout and the CMV43 trans-genic mice exhibit heart defects associated with malformations in the conotruncus, a region of the heart in which neural crest derivatives are known to have important roles during development. Together with our...