... is highly expressed in non-myocytes and potently regulates heart development. Ebf1 -deficient hearts display myocardial hypercellularity and reduced cardiomyocyte size, ventricular conduction system hypoplasia, and conduction system disease. Growth abnormalities in Ebf1 knockout hearts are observed as early...

... is common across evolution. Functions of such polyploidy are essentially unknown. Here, in both Drosophila larvae and human organ donors, we reveal distinct polyploidy levels in cardiac organ chambers. In Drosophila , differential growth and cell cycle signal sensitivity leads the heart chamber to reach...

... as an indispensable heart inducer. A detailed analysis of the role of Bmp4 and its effectors Smad1/5, however, was still missing. We show that Bmp4 induces cardiac mesoderm formation in murine embryonic stem cells in vitro . Bmp4 first activates Wnt3 and upregulates Nodal . pSmad1/5 and the WNT effector Tcf3 form...

...Xiaofei Li; Callie McLain; Michael S. Samuel; Michael F. Olson; Glenn L. Radice ABSTRACT The cardiomyocyte phenotypic switch from a proliferative to terminally differentiated state results in the loss of regenerative potential of the mammalian heart shortly after birth. Nonmuscle myosin IIB (NM IIB...

... is formed by invaginations of the plasma membrane and grows via re-routing of the recycling endosomal pathway. This is achieved by inactivation of other membrane-consuming pathways and a plasma membrane-like molecular signature of the compartment in these highly specialised heart cells. * Present...

...) pathway lead to severe brain malformations with variable penetrance due to unknown modifier genes. To identify such modifiers, we established novel congenic mouse models. LRP2-deficient C57BL/6N mice suffer from heart outflow tract defects and holoprosencephaly caused by impaired SHH activity...

... of new therapies is lagging compared with other fields. One major bottleneck hindering progress is the lack of self-organizing human cardiac models that recapitulate key aspects of human heart development, physiology and disease. Current in vitro cardiac three-dimensional systems are either engineered...

...Ian J. Begeman; Kwangdeok Shin; Daniel Osorio-Méndez; Andrew Kurth; Nutishia Lee; Trevor J. Chamberlain; Francisco J. Pelegri; Junsu Kang ABSTRACT Heart regeneration in regeneration-competent organisms can be accomplished through the remodeling of gene expression in response to cardiac injury...

... and differential state of multiple cell types, during both development and adulthood. Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart regeneration, and that absence of runx1 results in increased myocardial survival and proliferation, and overall heart regeneration...

... of the molecular mechanisms of regeneration. Heart Regeneration Spinal cord Tail Xenopus Appendage Biotechnology and Biological Sciences Research Council 10.13039/501100000268 BB/M011208/1 British Heart Foundation 10.13039/501100000274 RM/17/2/33380 The goal...

.../ Highlighted Article: Monitor lizards, which have the most-pronounced ventricular septation of lizards, express evolutionarily conserved transcription factors and exhibit a specialized manner of electrical activation. Heart Ventricular septum Evolution Lizard Carlsbergfondet 10.13039...

... that are important for BAF complex composition and for regulating cardiac gene expression. Heart Differentiation Chromatin Gene regulation National Institutes of Health 10.13039/100000002 2T32- HL007731 26 National Heart, Lung, and Blood Institute 10.13039/100000050 R01HL085860...

...Vanessa Lowe; Laura Wisniewski; Jacob Sayers; Ian Evans; Paul Frankel; Nadia Mercader-Huber; Ian C. Zachary; Caroline Pellet-Many ABSTRACT Unlike adult mammals, zebrafish can regenerate their heart. A key mechanism for regeneration is the activation of the epicardium, leading to the establishment...

...Julie L. M. Moreau; Scott Kesteven; Ella M. M. A. Martin; Kin S. Lau; Michelle X. Yam; Victoria C. O'Reilly; Gonzalo del Monte-Nieto; Antonio Baldini; Michael P. Feneley; Anne M. Moon; Richard P. Harvey; Duncan B. Sparrow; Gavin Chapman; Sally L. Dunwoodie ABSTRACT Congenital heart disease (CHD...

...Monika Zmojdzian; Svetlana de Joussineau; Jean Philippe Da Ponte; Krzysztof Jagla ABSTRACT The Drosophila heart, composed of discrete subsets of cardioblasts and pericardial cells, undergoes Hox-triggered anterior-posterior morphogenesis, leading to a functional subdivision into heart proper...

...Jun-yi Zhu; Amy Heidersbach; Irfan S. Kathiriya; Bayardo I. Garay; Kathryn N. Ivey; Deepak Srivastava; Zhe Han; Isabelle N. King miR-1 is a small noncoding RNA molecule that modulates gene expression in heart and skeletal muscle. Loss of Drosophila miR-1 produces defects in somatic muscle...

...Ayano Chiba; Haruko Watanabe-Takano; Kenta Terai; Hajime Fukui; Takahiro Miyazaki; Mami Uemura; Hisashi Hashimoto; Masahiko Hibi; Shigetomo Fukuhara; Naoki Mochizuki ABSTRACT The heart is an endocrine organ, as cardiomyocytes (CMs) secrete natriuretic peptide (NP) hormones. Since the discovery...

...’. As I review here, participants at the workshop revealed how understanding cardiac growth and lineage decisions at their most fundamental level has transformed the strategies in hand that presently energize the prospects for human heart repair. I am grateful to Brian Black and James Martin...

... to replace the scar and rebuild normal functioning tissue. Here, we address this problem in the context of heart disease, and discuss the origins and characteristics of cardiac fibroblasts, as well as the crucial role that they play in cardiac development and disease. We discuss the dual nature of cardiac...

...Michael G. Monaghan; Miriam Linneweh; Simone Liebscher; Ben Van Handel; Shannon L. Layland; Katja Schenke-Layland The elucidation of mechanisms in semilunar valve development might enable the development of new therapies for congenital heart disorders. Here, we found differences in proliferation...