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Keywords: hand2
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Journal Articles
Journal: Development
Development (2021) 148 (15): dev198408.
Published: 10 August 2021
... of lateral vessel progenitors (LVPs). These phenotypes contrast with the increased IM and absent LVPs observed with loss of the bHLH transcription factor Hand2, and loss of hand2 partially suppresses osr1 mutant phenotypes. hand2 and osr1 are expressed together in the posterior mesoderm, but osr1 expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev177477.
Published: 04 July 2019
... systemically explored. Here, we revealed a gradient of HAND2 protein in cardiac progenitors in the anterior dorsal pericardial wall (aDPW) and adjacent transition zone (TZ) in the outflow tract (OFT). Deletion of Hand2 caused cell arrest and accumulation in the TZ, leading to defective morphogenesis. Although...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev176198.
Published: 04 July 2019
... remain challenging. Here, using multiple knockout mouse models and single cell RNA sequencing, we demonstrate that the divergent lncRNA Hand2os1 / Uph has a key complex modulatory effect on the expression of its neighboring gene HAND2 and subsequently on heart development and function. Short deletion...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (16): 2994–3005.
Published: 15 August 2017
.... and Kimmel , C. B. ( 2003 ). Two endothelin 1 effectors, hand2 and bapx1, pattern ventral pharyngeal cartilage and the jaw joint . Development   130 , 1353 - 1365 . 10.1242/dev.00339 Minoux , M. and Rijli , F. M. ( 2010 ). Molecular mechanisms of cranial neural crest cell migration...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (16): 3112–3122.
Published: 15 August 2014
... cardiomyocytes. The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in promoting cardiomyocyte formation. It is unclear, however, whether Hand2 plays an instructive or permissive role during this process. Here, we find that overexpression of hand2 in the early zebrafish embryo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (18): 3754–3764.
Published: 15 September 2013
... alx4a activated expression in fibroblasts and osteoblasts within anterior fin rays, whereas hand2 regulatory sequences activated expression in these same cell types within posterior rays. Transgenic overexpression of hand2 in all pectoral fin rays did not affect formation of the proliferative...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (13): 2765–2775.
Published: 01 July 2013
... that ectopic joints develop at the expense of cartilage. Time-lapse experiments suggest that barx1 controls the skeletal precursor cell choice between differentiating into cartilage versus joint cells. We discovered that barx1 functions in this choice, in part, by regulating the transcription factor hand2. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1620–1629.
Published: 01 May 2012
...Junji Itou; Hiroko Kawakami; Thu Quach; Marco Osterwalder; Sylvia M. Evans; Rolf Zeller; Yasuhiko Kawakami How divergent genetic systems regulate a common pathway during the development of two serial structures, forelimbs and hindlimbs, is not well understood. Specifically, HAND2 has been shown...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (21): 4789–4800.
Published: 01 November 2011
...Jun Lei; Marthe J. Howard Targeted deletion of the bHLH DNA-binding protein Hand2 in the neural crest, impacts development of the enteric nervous system (ENS), possibly by regulating the transition from neural precursor cell to neuron. We tested this hypothesis by targeting Hand2 deletion in nestin...
Journal Articles
Journal: Development
Development (2010) 137 (19): 3215–3220.
Published: 01 October 2010
...Zayra V. Garavito-Aguilar; Heather E. Riley; Deborah Yelon Heart formation requires the fusion of bilateral cardiomyocyte populations as they move towards the embryonic midline. The bHLH transcription factor Hand2 is essential for cardiac fusion; however, the effector genes that execute...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (15): 2507–2517.
Published: 01 August 2010
...Jared Coffin Talbot; Stephen L. Johnson; Charles B. Kimmel The ventrally expressed secreted polypeptide endothelin1 (Edn1) patterns the skeleton derived from the first two pharyngeal arches into dorsal, intermediate and ventral domains. Edn1 activates expression of many genes, including hand2...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (6): 933–942.
Published: 15 March 2009
...Ning Liu; Ana C. Barbosa; Shelby L. Chapman; Svetlana Bezprozvannaya; Xiaoxia Qi; James A. Richardson; Hiromi Yanagisawa; Eric N. Olson The basic helix-loop-helix (bHLH) transcription factor Hand2 is required for growth and development of the heart, branchial arches and limb buds. To determine...
Journal Articles
Journal: Development
Development (2006) 133 (20): 4015–4024.
Published: 15 October 2006
...Marsha E. Lucas; Frank Müller; Roland Rüdiger; Paul D. Henion; Hermann Rohrer The basic helix-loop-helix transcription factor Hand2 , together with Ascl1, Phox2a, Phox2b and Gata2/Gata3 , is induced by bone morphogenetic proteins in neural crest-derived precursor cells during sympathetic neuron...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (1): 189–201.
Published: 01 January 2005
...David G. McFadden; Ana C. Barbosa; James A. Richardson; Michael D. Schneider; Deepak Srivastava; Eric N. Olson The basic helix-loop-helix transcription factors Hand1 and Hand2 display dynamic and spatially restricted expression patterns in the developing heart. Mice that lack Hand2 die at embryonic...
Journal Articles
Journal: Development
Development (2003) 130 (7): 1353–1365.
Published: 01 April 2003
... and joints in the anterior pharyngeal arches of young larvae. Here we present genetic analyses in the zebrafish of two edn1 downstream targets, the bHLH transcription factor Hand2 and the homeobox transcription factor Bapx1, that mediate dorsoventral (DV) patterning in the anterior pharyngeal arches. First...