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Journal Articles

The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions

Shaun Cordes, C. Andrew Frank, Gian Garriga
Journal: Development
Development (2006) 133 (14): 2747–2756.
https://doi.org/10.1242/dev.02447
Published: 15 July 2006
... MELK PAR-1 PIG-1 HAM-1 Cell polarity Cell fate Programmed cell death Apoptosis Much of metazoan cellular diversity is generated by asymmetric cell divisions in which a polarized mother cell divides to produce daughters that adopt different fates ( Horvitz and Herskowitz, 1992 ). The C...
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Journal Articles

Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates

Catherine Guenther, Gian Garriga
Journal: Development
Development (1996) 122 (11): 3509–3518.
https://doi.org/10.1242/dev.122.11.3509
Published: 1 November 1996
...Catherine Guenther; Gian Garriga ABSTRACT One mechanism of generating cellular diversity is to distribute developmental potential asymmetrically to daughter cells at mitosis. Two observations described in this report suggest that the C. elegans HAM-1 protein functions in dividing neuroblasts...
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