... 2008. 2008 Dlx3 Hair cycle Homeobox Mouse Ectodermal appendages such as hair, feather and tooth are attractive models for understanding the mechanisms underlying epithelial-mesenchymal interactions ( Thesleff et al.,1995 ; Mikkola and Millar,2006 ). A series of signaling molecules...

... and adult mouse epidermis. Loss of TAF4 in the foetal epidermis results in reduced expression of the genes required for skin barrier function, leading to early neonatal death. By contrast, TAF4 inactivation in adult epidermis leads to extensive fur loss and an aberrant hair cycle characterised...

... follicle Hair cycle Stem cells Epidermis Sebocytes Differentiation Label-retaining cells β-catenin Adult mammalian epidermis is maintained by stem cells that have the ability to self-renew and also to generate daughter cells that differentiate along the lineages of the hair follicle (HF...

... regrowth and loss. During the hair cycle, Msx2 deficiency shortens anagen phase, but prolongs catagen and telogen. Msx2 -deficient hair shafts are structurally abnormal. Molecular analyses suggest a Bmp4/Bmp2/Msx2/Foxn1 acidic hair keratin pathway is involved. These structurally abnormal hairs are easily...

... and aberrant terminal differentiation, accompanied by an inflammatory reaction of the skin. Our data not only provide genetic evidence that RXRα/VDR heterodimers play a major role in controlling hair cycling, but also suggest that additional signalling pathways mediated by RXRα heterodimerised with other...

... growth cycle. We examined this hypothesis by studying the expression of TIMP at selected times during a single hair cycle using T1MP– lacZ transgenic mice to localize TIMP gene activity in the hair follicle. TIMP gene induction was visualized by staining mouse back skin for β -galactosidase ( β -gal...