... field. This so-far-ignored AMP role involves their filopodia-based interactions with nerve growth cones. In parallel, we report the previously undetected expression of the guidance molecule-encoding genes sidestep and side IV in AMPs. Altogether, our data support the view that Drosophila muscle stem...

... Motoneuron Wiring Guidance Blood vessels exhibit hierarchical branching from the central vessel (aorta) to the periphery (capillaries in the organs). Similarly, the neural network is formed according to the hierarchical connection originating from the central nervous system to the peripheral...

... neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons. Simultaneously, they promote hypophyseal vascularisation, exerting early direct effects on endothelial cells that are subsequently complemented by indirect effects. Together, our studies suggest a model for the integrated...

... ) Competing interests statement The authors declare no competing financial interests. 21 7 2011 © 2011. TRIM Sea urchin embryo Ectoderm Skeleton biomineralization Morpholino oligonucleotides Primary mesenchyme Cell migration Guidance otp pax2/5/8 sm30...

... central nervous system. J. Anat. 211 , 600 -611. Gagliardini, V. and Fankhauser, C. ( 1999 ). Semaphorin III can induce death in sensory neurons. Mol. Cell. Neurosci. 14 , 301 -316. Gammill, L. S., Gonzalez, C., Gu, C. and Bronner-Fraser, M. ( 2006 ). Guidance of trunk neural crest...

..., and segregate from each other to form a mosaic of distinct compartments. However, the molecular mechanisms that underlie this time-dependent process of neuronal segregation remain largely unknown. Using a novel organotypic assay, we identified ephrin/Eph family members as guidance cues that regulate matrix...

...Kelly A. Palaisa; Michael Granato One of the earliest guidance decisions for spinal cord motoneurons occurs when pools of motoneurons orient their growth cones towards a common,segmental exit point. In contrast to later events, remarkably little is known about the molecular mechanisms underlying...

... evidence that localized VEGF acts as both a guidance cue and a differentiation signal, providing a crucial link between the positioning and differentiation of the migrating PMCs and leading to morphogenesis of the embryonic skeleton. * Author for correspondence (e-mail: [email protected]...

...Asha Dwivedy; Frank B. Gertler; Jeffrey Miller; Christine E. Holt; Cecile Lebrand The Enabled/vasodilator-stimulated phosphoprotein (Ena/VASP) family of proteins is required for filopodia formation in growth cones and plays a crucial role in guidance cue-induced remodeling of the actin cytoskeleton...

...Claire Y. Bénard; Hania Kébir; Shin Takagi; Siegfried Hekimi The gene mau-2 has been found to be required for the guidance of cellular and axonal migrations along both the anteroposterior and the dorsoventral body axes during the development of the nematode C. elegans . We show that mau-2 encodes...

...Kagayaki Kato; Takahiro Chihara; Shigeo Hayashi The migration of cellular extensions is guided by signals from tissues with which they contact. Many axon guidance molecules regulate growth cone migration by directly regulating actin cytoskeletal dynamics. Secreted morphogens control global patterns...

... a role for NO in the regulation of pollen tube growth, a fast tip-growing cellular system. Pollen tubes must be precisely oriented inside the anatomically complex female ovary in order to deliver sperm. We hypothesized that NO could play a role in this guidance and tested this hypothesis by challenging...

... cones to promote axon defasciculation. We identify a family of 14 beat -like genes in Drosophila . In contrast to beat Ia , four novel Beat-family genes encode membrane-bound proteins. Moreover, mutations in each gene lead to much more subtle guidance phenotypes than observed in beat Ia . Genetic...

... new sax genes that affect the morphology of nerve ring axons. sax-3/robo mutations disrupt axon guidance in the nerve ring, while sax-5, sax-9 and unc-44 disrupt both axon guidance and axon extension. Axon extension and guidance proceed normally in sax-1, sax-2, sax-6, sax-7 and sax-8 mutants...

... fasciculation. Here we demonstrate a role for fasciclin II in the guidance of migratory neurons. In the developing enteric nervous system of the moth Manduca sexta , an identified set of neurons (the EP cells) undergoes a stereotyped sequence of migration along the visceral muscle bands of the midgut prior...

... by Company of Biologists 1997 cortex basal telencephalon axon outgrowth guidance chemoattractant netrin-1 Growing axons are guided towards their targets along specific pathways by multiple cues present in the environment of their growth cones, to which they respond with complex growth...

... collapsin-1 semaphorin-D semaphorin-III spinal cord sensory afferent trk-C antibody repulsion repellent growth cone collapse guidance pathfinding chick The correct wiring together of the nervous system requires that specific axonal growth cones respond appropriately to a variety...

... and resume normal elongation. These results support the hypothesis that cell surface galtase activity plays an important role in mediating neurite elongation and suggest further that differential expression of galtase at the nerve growth cone might contribute to axonal guidance through glycoconjugate-rich...

..., University of Utah, Salt Lake City, Utah 84112, USA † Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA ‡ Battelle, Pacific Northwest Labs, Box 999, Richland, WA 99352, USA 04 06 1990 © 1990 by Company of Biologists 1990 adhesion guidance...

... neurone specificity growth guidance substrate Rana temporaria The generation of neuronal specificity during development and regeneration can be examined broadly in two stages; the growth of an axon to the near vicinity of its target cell and the creation of a functional synapse...