... to explore the role that organs distant from an injury can play in regeneration. Tissue regeneration Hormones Circulating factors Growth factors Enhancers Organ communication National Institutes of Health http://dx.doi.org/10.13039/100000002 R35 HL150713 R21 NS124635 R01 AR076342...

... Asymmetric cell division Centrosome Growth factors Primary microcephaly During embryonic development in higher vertebrates, the brain and anterior spinal cord are formed through primary neurulation of the embryonic neural plate, which produces a hollow neural tube (NT) that acts as the primordium...

... by The Company of Biologists Ltd 2017 Summary: This Primer discusses the complex embryo-uterine interactions that induce, maintain and reactivate the blastocyst from diapause, highlighting the roles of hormones, cytokines and growth factors across animal species. Embryo Diapause Uterus...

...Yongyou Zhang; Jue Zhang; Yongshun Lin; Yongsheng Lan; Chunhong Lin; Jim W. Xuan; Michael M. Shen; Wallace L. McKeehan; Norman M. Greenberg; Fen Wang The fibroblast growth factor (FGF) regulates a broad spectrum of biological activities by activation of transmembrane FGF receptor (FGFR) tyrosine...

... acquisition of skin barrier function during development. Development 125 , 1541 -1552. Hocevar, B. A., Smine, A., Xu, X. X. and Howe, P. H. ( 2001 ). The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. EMBO J. 20 , 2789 -2801. Hocevar, B...

... the activation of the arterial markers ephrinB2 and neuropilin 1. * Author for correspondence (e-mail: [email protected] ) 17 10 2003 © 2004. 2004 Arterial-venous differentiation Hemodynamic forces Growth factors Receptors Ephrin Neuropilin In the adult...

...Andy J. Fischer; Blair D. Dierks; Thomas A. Reh Neural progenitors at the retinal margin of the post-hatch chicken normally produce amacrine and bipolar cells, but not photoreceptor or ganglion cells. The purpose of this study was to test whether exogenous growth factors influence the types...

...Geeta S. Vemuri; F. Arthur McMorris ABSTRACT Signal transduction in response to several growth factors that regulate oligodendrocyte development and survival involves the activation of phosphatidylinositol 3-kinase, which we detect in oligodendrocytes and their precursors. To investigate the role...

... in which purified HMP1, anti-HMP1 IgG, or suspected substrates of HMP1 (e.g. growth factors such as TGF-β 1 ) were introduced into the inter-epithelial compartment of hydra using a ‘DMSO loading’ procedure. These studies indicated that HMP1 has a functional role during a number of developmental processes...

... precursors. When the nonlimbic precursors are grown on Matrigel, there is a 2-fold increase in the number of MAP2 + /LAMP + double-labeled neurons. Dissection of the Matrigel components reveals that in combination with growth factor-deficient Matrigel or collagen type IV, epidermal growth factor...

...Choy May Chia; Robert M. L. Winston; Alan H. Handyside ABSTRACT Epidermal growth factor (EGF) and transforming growth factor alpha (TGF-α) through their common receptor, epidermal growth factor receptor (EGFR) are known to enhance mitogenesis, development and implantation in several species...

... growth factors In mammals the pancreas originates from the primitive gut through the fusion of two anlagen, which first appear as dorsal and ventral epithelial evaginations surrounded by caps of mesenchymal cells ( Pictet et al., 1972 ). The original buds give rise to branching epithelial ducts...

...Patricia A. Labosky; Denise P. Barlow; Brigid L. M. Hogan ABSTRACT Primordial germ cells of the mouse cultured on feeder layers with leukemia inhibitory factor, Steel factor and basic fibroblast growth factor give rise to cells that resemble undifferentiated blastocyst-derived embryonic stem cells...

.... Trans. R. Soc. London B 339 , 173 – 181 . 10.1098/rstb.1993.0014 Linsmaier , B. and Skoog , F. ( 1965 ). Organic growth factor requirements of tobacco tissue culture . Physiol. Plant . 18 , 100 – 127 . 10.1111/j.1399-3054.1965.tb06874.x Matzke , M. and Matzke...

... previously shown that myotubes release mitogens into the medium that stimulate myoblast proliferation ( De Angelis et al., 1992 ). Furthermore immunohistochemical and in situ hybridization studies have revealed the presence of peptide growth factors and their messages within developing muscles in the embryo...

...Robert A. Cornell; David Kimelman ABSTRACT The early patterning of mesoderm in the Xenopus embryo requires signals from several intercellular factors, including mesoderm-inducing agents that belong to the fibroblast growth factor (FGF) and TGF-β families. In animal hemisphere explants (animal caps...

... 1993 © 1993 by Company of Biologists 1993 Xenopus Wnt embryonic development pattern formation growth factors morphogenesis There is considerable interest in the molecules and mechanisms that underlie pattern formation, and the discovery that Wnt -1 ( int -1...

...Rosanna Dono; Lorenzo Scalera; Francesco Pacifico; Dario Acampora; M. Graziella Persico; Antonio Simeone ABSTRACT The murine cripto gene encodes a 171-aminoacid epidermal growth factor-related protein, with 93% similarity to its human counterpart in the ‘EGF-like’ domain. The murine cripto mRNA...

.... , McMahon , J. A. , McMahon , A. P. and Moon , R. T. ( 1991 ). Xwnt8, a Xenopus Wnt1/int-1-related gene responsive to mesoderm inducing growth factors, may play a role in ventral mesodermal patterning during embryogenesis . Development 111 , 1045 – 1055 . Christian , J. L...

...Josephine C. Adams; Fiona M. Watt Introduction Evidence that cell-ECM interactions regulate differentiation and development Developmental mutations Experimental perturbation of embryonic development Cell and organ cultures Regulatory mechanisms ECM diversity Interactions of growth factors...