... is not specifically dorsal, is difficult to explain using the conventional model of ephrins binding to Eph receptors on axon growth cones and triggering intracellular signaling through Eph phosphorylation. Rather, it indicates that the EphB2 extracellular domain may act independently in pathfinding, possibly...

... of these neurons to obtain a detailed description of the morphology of their growth cones and of the pathways that they follow. We have divided the sequence of axon growth from these neurons into five major phases. In the first phase, the growth cone of each RP axon grows medially along its contralateral homologue...

... by a ‘delayed interstitial budding’ of collaterals from layer 5 corticospinal axons, rather than by a direct ingrowth of primary axons or by bifurcation of the growth cone. Branches form de novo from the axon cylinder in the pathway overlying the basilar pons and extend directly into it. Cocultures of cortex...

...Hilary Anderson; Richard P. Tucker During axonogenesis, contacts made by the growth cone with its substratum are important in guiding the direction of neurone outgrowth. This study examines the contacts made by the growth cones of pioneer neurones in the embryonic grasshopper limb. Individual...