... cells Granule cells Cerebellar nuclei Cell plasticity Injury National Institute of Neurological Disorders and Stroke http://dx.doi.org/10.13039/100000065 R01NS092096 K99/R00 NS112605-01 National Institute of Mental Health http://dx.doi.org/10.13039/100000025 R37MH085726...

... as a novel transcriptional regulator in the postnatal organization and function of the hippocampus. Here, we dissect its role in DG morphogenesis by inactivating it in either granule cell progenitors or granule neurons. Loss of COUP-TFI function in progenitors leads to decreased granule cell proliferative...

... cortex have been specified. Changes in spatially restricted gene expression occur prior to foliation in mutants, and foliation is altered from the onset and is accompanied by changes in the thickness of the layer of proliferating granule cell precursors. In addition, the positioning and timing of fissure...

...(+) granule cells in the granule cell layer (GCL). (S-V) A magnified view of the GCL. A triple-labeled section for Arx (red in S,V), GABA (green in T,V: granule cells), and GLAST (blue in U,V: radial glia). Arrows in (S-V): Arx(+) and GABA(+) granule cells. Arrowheads in (S-V): Arx(+) and GLAST(+) radial glia...

...Joshua B. Rubin; Yoojin Choi; Rosalind A. Segal Sonic hedgehog promotes proliferation of developing cerebellar granule cells. As sonic hedgehog is expressed in the cerebellum throughout life it is not clear why proliferation occurs only in the early postnatal period and only in the external granule...

... these zones. Here we show that migration of cerebellar granule cells out of their proliferative zone, the external granule cell layer (EGL), is impaired in Bdnf –/– mice. The reason for impaired migration is that BDNF directly and acutely stimulates granule cell migration. Purified Bdnf –/– granule cells show...

... in the developing forebrain of the mouse. Lef1 is expressed in the developing hippocampus, and LEF1-deficient embryos lack dentate gyrus granule cells but contain glial cells and interneurons in the region of the dentate gyrus. In mouse embryos homozygous for a Lef1-lacZ fusion gene, which encodes a protein...

... granule cell progenitors at the rhombic lip as they separate from the ventricular zone of the neural tube to generate a secondary proliferative matrix, and it continues to be expressed in differentiating and mature granule neurons. Proliferating granule cell progenitors isolated from the rhombic lip...

... postnatally as granule cells start to make contacts with Purkinje cells. To investigate whether interactions with granule cells influence Wnt -3 expression in Purkinje cells, we examined gene expression in several mouse mutants, using the expression of En- 2 to follow the fate of granule cells. In the weaver...