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Keywords: gradient
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Journal Articles
Journal: Development
Development (2022) 149 (7): dev200332.
Published: 8 April 2022
... results lead to two major conclusions. First, both LBS number and configuration impact cluster activity: LBSs act additively in trans and synergistically in cis . Second, the SYGL-1 gradient promotes self-renewal above its functional threshold and triggers differentiation below the threshold. Our approach...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (2): dev196113.
Published: 20 January 2021
... 138 , 915 - 924 . 10.1242/dev.057729 Al Asafen , H. , Bandodkar , P. U. , Carrell-Noel , S. , Schloop , A. E. , Friedman , J. and Reeves , G. T. ( 2020 ). Robustness of the Dorsal morphogen gradient with respect to morphogen dosage . PLoS Comput. Biol. 16...
Journal Articles
Journal: Development
Development (2019) 146 (3): dev168955.
Published: 1 February 2019
... polarised along a tissue axis. We propose that these bridges provide a general mechanism by which cells interpret different forms of tissue gradients to coordinate directional information. We illustrate this using a generalised and consistent modelling framework, providing a conceptual basis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2017) 144 (10): 1876–1886.
Published: 15 May 2017
... and cell shape in the Drosophila mesoderm. We found that cells within the ventral domain accumulate different amounts of active apical non-muscle myosin 2 depending on the distance from the ventral midline. This gradient in active myosin depends on a newly quantified gradient in upstream signaling proteins...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (22): 4149–4160.
Published: 15 November 2016
...Miquel Sureda-Gómez; José M. Martín-Durán; Teresa Adell The β-catenin-dependent Wnt pathway exerts multiple context-dependent roles in embryonic and adult tissues. In planarians, β-catenin-1 is thought to specify posterior identities through the generation of an anteroposterior gradient. However...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (4): 729–736.
Published: 15 February 2014
... of Biologists Ltd 2014 Cytoneme plasticity Cytoneme transfer Drosophila Filopodia Morphogen Gradient The number of scholarly reviews on the topic of morphogen signaling published in the past two years exceeds the number of known morphogens; the reader is referred to excellent...
Journal Articles
Journal: Development
Development (2013) 140 (22): 4544–4553.
Published: 15 November 2013
... three syncytial mitoses, followed by cellularisation that forms seven cells belonging to four cell types. The specification of cell fates in the FG has been suggested to depend on positional information provided by an intrinsic auxin concentration gradient. The goal of this study was to develop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (14): 2917–2922.
Published: 15 July 2013
... debate whether the Dpp gradient is required for the uniform cell proliferation observed in the wing imaginal disc. Here, we investigated how the Dpp signaling pathway regulates proliferation during wing development. By systematic manipulation of Dpp signaling we observed that it controls proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1621–1638.
Published: 15 April 2013
...Patrick Müller; Katherine W. Rogers; Shuizi R. Yu; Michael Brand; Alexander F. Schier The graded distribution of morphogens underlies many of the tissue patterns that form during development. How morphogens disperse from a localized source and how gradients in the target tissue form has been under...
Journal Articles
Journal: Development
Development (2012) 139 (19): 3665–3674.
Published: 1 October 2012
... of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells. We propose that cells normally use this mechanism to read the local slope of tissue-wide gradients of Fz activity, so that all cells come to point in the same direction. References Adler P. N...
Journal Articles
Journal: Development
Development (2012) 139 (4): 625–639.
Published: 15 February 2012
... statement The authors declare no competing financial interests. © 2012. Gradient Modeling Negative feedback Oscillator Signaling Somitogenesis The segmented anatomy of the vertebrate embryo is evident in the two bilaterally symmetrical rows of somites that flank...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 551–561.
Published: 15 February 2009
... in cells producing the TGFα-like ligand Gurken,but not in EGFR-expressing cells. Strikingly, we find that GSLs are not essential for Gurken trafficking and secretion. However, we characterize for the first time the extracellular Gurken gradient and show that GSLs affect its formation by controlling Gurken...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (3): 461–472.
Published: 1 February 2009
... of XRDH10 and XRALDH2 constitute a`biosynthetic enzyme code' for the establishment of a morphogen gradient in the embryo. To address whether XRDH10 is involved in vitamin A metabolism, we investigated the effects of downregulating the XRDH10 enzyme in the presence of exogenous retinol ( Fig. 8T-W...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3339–3348.
Published: 15 September 2007
...Lisa M. Galli; Tiffany L. Barnes; Stephanie S. Secrest; Tatsuhiko Kadowaki; Laura W. Burrus A long-term goal of developmental biology is to understand how morphogens establish gradients that promote proper tissue patterning. A number of reports describe the formation of the Wg (Wnt1) gradient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (1993) 119 (4): 971–976.
Published: 1 December 1993
...Peter A. Lawrence; Javier Sampedro 20 9 1993 © 1993 by Company of Biologists 1993 Drosophila segmentation parasegment pair rule genes segment polarity genes gradient REFERENCES Bejsovec A. , Martinez-Arias A. ( 1991 ). Roles of wingless in patterning...
Journal Articles
Journal: Development
Development (1988) 104 (Supplement): 3–16.
Published: 1 October 1988
...Vernon French `Morphogen' gradients have long been invoked as a means of specifying spatial patterns of developmental fate, and it has now been demonstrated that they are indeed involved in the early steps of insect segmentation. In many insects, including Drosophila , ligature and transplantation...
Journal Articles
Journal: Development
Development (1985) 87 (1): 207–213.
Published: 1 June 1985
... towards the acid side of a pH gradient. The suggestion is offered that these results can be interpreted in terms of the effects of NH 3 . It appears to be an additional mechanism (besides phototaxis and thermotaxis) to assure that the final fruiting takes place in a favourable environment. /. Embryol. exp...