...John Yochem; Simon Tuck; Iva Greenwald; Min Han ABSTRACT A genetic analysis of a gp330/megalin-related protein, LRP-1, has been undertaken in Caenorhabditis elegans . Consistent with megalin’s being essential for development of mice, likely null mutations reveal that this large member of the low...

... place from the 8-cell stage to the 64-cell stage and precedes their commitment at the blastocyst stage. In this work, we have investigated the expression of gp330, a 330×10 3 M r glycoprotein found in clathrin-coated areas of the plasma membrane of some epithelial cells characterized by a high level...

... epithelial differentiation gp330 Although the successive differentiative events of embryonic development depend upon the expression of a genetic program, cellular mechanisms exist that modulate that program and can direct the fate of a cell or of its progeny. During the preimplantation development...