... cell specification. Traffic jam Notch Stem cell niche Gonadogenesis Drosophila Our model suggests that Tj and Bowl mediate many aspects of hub cell fate downstream of Notch signaling. As noted above, a fraction of hub cells are still specified in bowl mutants, and these appear...

.... In contrast to a previous report, we did not observe significant conversion of steady-state CySC progeny to hub fate. However, we found that these two cell types derive from a common precursor pool during gonadogenesis. Furthermore, lines mutant embryos exhibited gonads containing excess hub cells, indicating...

..., as Serrate is expressed on the SGPs ( Kitadate and Kobayashi, 2010 ) and both Delta and Serrate are robustly expressed on tracheal cells ( Fig. 5 ), the activity of which might otherwise lead to excess hub cell induction. Last, perhaps during later stages of gonadogenesis (stages 14-16) a small number...

... for male gonadogenesis of C. elegans . During the L3 and L4 larval stages of wild-type males, the LC undergoes changes in its position along the migratory route, in transcriptional regulation of the unc-5 netrin receptor and zmp-1 zinc matrix metalloprotease, and in cell morphology. We have identified...

... © 2004. 2004 TRA-1 GLI EHN-3 Cell polarity Cell proliferation Gonadogenesis C. elegans TRA-1 is the single C. elegans homolog of the Ci/GLI family of zinc-finger transcription factors( Zarkower and Hodgkin, 1992 ). In flies and vertebrates, GLI acts in the hedgehog...

...-mail: [email protected] ) * These authors contributed equally to this work 7 5 2004 ©2004. 2004 Pod1 Tcf21 Sf1 Gonadogenesis Testis development Sex reversal Leydig cell Mammalian sexual differentiation is a complex process that begins with the establishment of genetic...

... 2 2004 © 2004. 2004 Cell polarity Ovulation Gonadogenesis Caenorhabditis elegans Acquisition of cell polarity is important to epithelial cells for carrying out their barrier function and for their proper movements during morphogenesis( Knust and Bossinger, 2002 ; Ohno...

... fkh-6 reporter is gonad-specific. Genetic and molecular analyses place fkh-6 downstream of tra-1 , the terminal regulator of the global sex determination pathway, with respect to the first gonadal cell division. We conclude that fkh-6 regulates gonadogenesis in both sexes, but is male specific...

...Laura D. Mathies; Samuel T. Henderson; Judith Kimble The C. elegans genome encodes a single Hand bHLH transcription factor. Either hnd-1(RNAi) or a hnd-1 deletion causes partially penetrant defects in viability and gonadogenesis. Dead embryos and young larvae are often misshapen at the posterior...

...Kellee R. Siegfried; Judith Kimble The shape and polarity of the C. elegans gonad is defined during early gonadogenesis by two somatic gonadal precursor cells, Z1 and Z4, and their descendants. Z1 and Z4 divide asymmetrically to establish the proximal-distal axes of the gonad and to generate...

...-9000, Gent, Belgium † Author for correspondence (e-mail: [email protected] ) 04 06 1998 21 07 1998 © 1998 by Company of Biologists 1998 Caenorhabditis elegans lin-26 Epithelial cell Gonadogenesis Tissue-specific knockout Despite the importance...

... they are specified is unknown. Here, we describe a novel regulator of Drosophila gonadogenesis, clift , mutations in which abolish gonad formation. clift is expressed within somatic gonadal precursors as these cells first form, demonstrating that 9-12 cells are selected as somatic gonadal precursors within each...

... 1995 primordial germ cells cell migration gonadogenesis Drosophila In many invertebrate and vertebrate animals, the formation of primordial germ cells (PGCs) is spatially and temporarily separated from the somatic gonad ( Nieuwkoop and Sutasurya, 1979 , 1981 ). Often PGCs form...

... tissue of the embryo rather than by a germ cell autonomous clock. Using mutations, we show that these controlling somatic events probably occur in the tissue of the gut primordium itself. © 1994 by Company of Biologists 1994 primordial germ cell gonadogenesis mutants cell motility...

...H. K. Parmentier; L. P. M. Timmermans ABSTRACT Gonadal development, germ cell differentiation and the appearance of membrane antigenic determinants, specific for male and female germ cells during gonadogenesis, was studied in larval and juvenile carp (Cyprinus carpio L.) until 25 weeks after...