... chordates, genetic studies of Crabp function have revealed few essential functions. We have generated loss-of-function mutations in all four zebrafish Crabps and find essential roles for Crabp2 proteins in gonad development and sex determination. Transgenic RA reporters show strong RA responses in germ...

... that the evolution of enhancers in the regulatory domain of SALL1 may have driven its expression in the testicular part of mole ovotestis. To investigate the effects of Sall1 expression during early gonadal development, we induced its expression in the mouse ovary. For this purpose, we created a BAC...

..., USA Competing interests statement The authors declare no competing financial interests. 17 9 2012 © 2012. Published by The Company of Biologists Ltd Leydig cell differentiation Adrenal development Gonad development Steroidogenic factor 1 Steroidogenic gene...

... primordial germ cells gonad development cell migration mucins chick rat Primordial germ cells (PGCs) are an undifferentiated population of cells in the embryo that serve as precursors of germ cells. PGCs are generated outside the embryo and enter the embryonic gonadal anlage first by following...