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Keywords: gonad
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2024) 151 (7): dev201102.
Published: 12 April 2024
...), are one of the first cell types specified during embryogenesis. In fact, PGCs form well before the bipotential somatic gonad is specified. This common feature of germline development necessitates that PGCs migrate through many tissues to reach the somatic gonad. During their journey, PGCs must respond...
Journal Articles
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (5): dev201060.
Published: 13 March 2023
...Corey Bunce; Lindsey Barske; Gloria Zhang; Blanche Capel ABSTRACT During mammalian development, gonadal sex determination results from the commitment of bipotential supporting cells to Sertoli or granulosa cell fates. Typically, this decision is coordinated across the gonad to ensure commitment...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2023) 150 (5): dev201466.
Published: 9 March 2023
...Martin A. Estermann; Andrew T. Major; Craig A. Smith ABSTRACT During gonadal sex determination, the supporting cell lineage differentiates into Sertoli cells in males and pre-granulosa cells in females. Recently, single cell RNA-seq data have indicated that chicken steroidogenic cells are derived...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (18): dev199208.
Published: 18 May 2021
...Corey Bunce; Jennifer McKey; Blanche Capel ABSTRACT During development of the mouse urogenital complex, the gonads undergo changes in three-dimensional structure, body position and spatial relationship with the mesonephric ducts, kidneys and adrenals. The complexity of genital ridge development...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (11): dev170001.
Published: 10 June 2019
...Nicole Camara; Cale Whitworth; Abigail Dove; Mark Van Doren ABSTRACT Sex-specific development of the gonads is a key aspect of sexual dimorphism that is regulated by Doublesex/Mab3-related transcription factors (DMRTs) in diverse animal species. We find that in mutants for Drosophila dsx...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2017) 144 (12): 2187–2199.
Published: 15 June 2017
... housekeeping function, as well as an extracellular signaling function mediated by the secreted MSPd. Here we show that the C. elegans VAP homolog VPR-1 is essential for gonad development. vpr-1 null mutants are maternal effect sterile due to arrested gonadogenesis following embryo hatching. Somatic gonadal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (23): 4461–4472.
Published: 1 December 2012
...Anne-Amandine Chassot; Stephen T. Bradford; Aurélie Auguste; Elodie P. Gregoire; Eric Pailhoux; Dirk G. de Rooij; Andreas Schedl; Marie-Christine Chaboissier The gonad arises from the thickening of the coelomic epithelium and then commits into the sex determination process. Testis differentiation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (13): 2283–2287.
Published: 1 July 2012
... indicate that lack of AMH signaling causes the hotei phenotype. BrdU incorporation experiments identified the existence of both quiescent and mitotically active germ cells among the self-renewing, type I population of germ cells in the developing gonad. AMH signaling acts in supporting cells to promote...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (2): 303–312.
Published: 15 January 2010
...Ryuji Hiramatsu; Kyoko Harikae; Naoki Tsunekawa; Masamichi Kurohmaru; Isao Matsuo; Yoshiakira Kanai In mouse embryogenesis, Sry is transiently activated in a center-to-pole wavelike manner along the anteroposterior (AP) axis of developing XY gonads. However, the mechanism and significance...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (8): 1519–1527.
Published: 15 April 2006
...Leo DiNapoli; Jordan Batchvarov; Blanche Capel In addition to its role in somatic cell development in the testis, our data have revealed a role for Fgf9 in XY germ cell survival. In Fgf9 -null mice, germ cells in the XY gonad decline in numbers after 11.5 days post coitum (dpc), while germ cell...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2415–2423.
Published: 15 May 2005
...Susan Y. Park; Joshua J. Meeks; Gerald Raverot; Liza E. Pfaff; Jeffrey Weiss; Gary D. Hammer; J. Larry Jameson Mutations of orphan nuclear receptors SF1 and DAX1 each cause adrenal insufficiency and gonadal dysgenesis in humans, although the pathological features are distinct. Because Dax1...
Journal Articles
Journal: Development
Development (2004) 131 (15): 3627–3636.
Published: 1 August 2004
... determination Sertoli cell Sry Gonad Testes Sex determination provides an ideal system for examining how a binary fate choice (male or female) is integrated with processes that govern growth and morphogenesis during development. The early gonad is morphologically identical in XX and XY individuals...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (6): 1425–1436.
Published: 15 March 2004
..., primary sex determination initially occurs in the gonad, with the sex of other tissues specified as a secondary event. In insects and nematodes, globally acting regulatory pathways have been elucidated, but the more tissue- and organ-specific downstream effectors of these pathways remain largely unknown...
Journal Articles
Journal: Development
Development (2003) 130 (24): 5895–5902.
Published: 15 December 2003
...Humphrey H.-C. Yao; Leo DiNapoli; Blanche Capel The developmental fate of primordial germ cells in the mammalian gonad depends on their environment. In the XY gonad, Sry induces a cascade of molecular and cellular events leading to the organization of testis cords. Germ cells are sequestered inside...
Journal Articles
Journal Articles
Journal: Development
Development (1997) 124 (1): 253–259.
Published: 1 January 1997
...Marie-Anne Félix; Paul W. Sternberg ABSTRACT How do intercellular signals that pattern cell fates vary in evolution? During nematode vulva development, precursor cells acquire one of three fates in a pattern centered around the gonadal anchor cell. Non-vulval fates are at the periphery, outer...
Journal Articles
Journal: Development
Development (1996) 122 (7): 2129–2142.
Published: 1 July 1996
...Marie-Anne Félix; Paul W. Sternberg ABSTRACT Whereas the hermaphrodite gonad of Caenorhabditis elegans has two symmetric arms (didelphy), the female/hermaphrodite gonad of many nematode species features a single anterior arm (monodelphy). We examined how gonadal cell lineages and intercellular...
Journal Articles
Journal: Development
Development (1992) 116 (4): 1185–1192.
Published: 1 December 1992
...Jenny J. Brookman; Ahmed T. Toosy; Shashidhara L. S.; Robert A. H.White ABSTRACT We have shown that the expression of the 412 retrotransposon provides a useful early marker for the development of the gonadal mesoderm in Drosophila embryos. 412 is initially expressed in a set of parasegmentally...
Journal Articles