..., distribution and reproduction in any medium provided that the original work is properly attributed. Summary: This Primer introduces the role of O-GlcNAcylation, an essential post-translational modification, in stem cells and development. O-GlcNAcylation Glycosylation Polycomb group proteins...

...Sevinç Gücüm; Roman Sakson; Marcus Hoffmann; Valerian Grote; Clara Becker; Kaisa Pakari; Lars Beedgen; Christian Thiel; Erdmann Rapp; Thomas Ruppert; Thomas Thumberger; Joachim Wittbrodt ABSTRACT Defects in the evolutionarily conserved protein-glycosylation machinery during embryonic development...

... is properly attributed. Summary: The O-fucosyltransferase SPY regulates root hair patterning independently of DELLA proteins and gibberellin signaling when modulating epidermal tissue patterning in Arabidopsis   thaliana roots. Arabidopsis Root hair patterning Glycosylation Gibberellin...

...Erika Negreiros; Sophie Herszterg; Kyung-Hwa Kang; Amanda Câmara; Wagner B. Dias; Katia Carneiro; Ethan Bier; Adriane Regina Todeschini; Helena Araujo ABSTRACT Disorders of N-linked glycosylation are increasingly reported in the literature. However, the targets that are responsible...

... mutant embryos have intrinsic defects in palatal shelf elevation. Just prior to the developmental stage of palatal shelf elevation in wild-type littermates, Golgb1 mutant embryos exhibit increased cell density, reduced hyaluronan accumulation and impaired protein glycosylation in the palatal mesenchyme...

... glycosylation are unknown. A genetic screen for relevant mutations in Drosophila generated the sugar-free frosting (sff) mutant that reveals a new function for protein kinases in regulating substrate flux through specific Golgi processing pathways. Sff is the Drosophila homolog of SAD kinase, which regulates...

...Achim Haecker; Mattias Bergman; Christine Neupert; Bernard Moussian; Stefan Luschnig; Markus Aebi; Mattias Mannervik N-linked glycosylation is a prevalent protein modification in eukaryotic cells. Although glycosylation plays an important role in cell signaling during development, a role for N...

... for the glycosylation and gonadal localization of MIG-17, but not for secretion of MIG-17 from muscle cells. Furthermore,COGC-3 requires MIG-17 activity for its action in DTC migration. Our findings demonstrate that COG complex-dependent glycosylation of an ADAM protease plays a crucial role in determining organ shape...

... indicate that glycosylation of an EGF domain proposed to be essential for ligand binding, EGF12, is crucial to the inhibition of Serrate-to-Notch signaling by Fringe. Expression of an EGF12 mutant of Notch(N-EGF12f) allows Notch activation by Serrate even in the presence of Fringe. By contrast, elimination...

...Antti Seppo; Parul Matani; Mary Sharrow; Michael Tiemeyer Specific glycan expression is an essential characteristic of developing tissues. Our molecular characterization of a mutation that abolishes neural-specific glycosylation in the Drosophila embryo demonstrates that cellular interactions...

... proteins and peripheral membrane proteins. Two-dimensional gel electrophoresis reveals an isoelectric point of about 6.4 for neurothelin. Polysaccharide analysis by glycosidase digestion and lectin binding indicates that neurothelin is highly glycosylated. The relative molecular mass of glycosylated...

..., Uppal Road, Hyderabad-500 007 India © 1989 by Company of Biologists 1989 glycosylation aggregation slime mold Dictyostelium discoideum cyclic AMP intercellular cohesion chemotaxis Upon starvation, amoebae of Dictyostelium discoideum enter a developmental program during...

... to the MSD1 region of myotube N-CAM. © 1989 by Company of Biologists 1989 N-CAM neural cell adhesion molecule glycosylation skeletal muscle carbohydrate Neural cell adhesion molecule (N-CAM) is a cell surface sialoglycoprotein that is involved in specific homophilic adhesive interactions...