... in mouse spinal neurulation, we administered chlorate, a competitive inhibitor of glycosaminoglycan sulphation, to cultured E8.5 embryos. Treated embryos exhibit accelerated posterior neuropore closure, accompanied by suppression of neuroepithelial bending at the median hinge point and accentuated bending...

... to that of wingless .UDP-glucose dehydrogenase is required for the biosynthesis of UDP-glucuronate, which in turn is utilized in the biosynthesis of glycosaminoglycans. By rescuing the kiwi phenotype with both UDP-glucuronate and the glycosaminoglycan heparan sulfate, we show that kiwi function in the embryo...

...Jamie Davies; Malcolm Lyon; John Gallagher; David Garrod ABSTRACT Kidney epithelia have separate origins; collecting ducts develop by ureteric bud growth and arborisation, nephrons by induced mesenchyme-epithelium transition. Both express sulphated glycosaminoglycans (GAGs) which are strikingly...

...F. Lafont; M. Rouget; A. Triller; A. Prochiantz; A. Rousselet ABSTRACT We have studied the effects of proteoglycans (PGs) and glycosaminoglycans (GAGs) on the growth and morphology of neurons in culture. PGs from glial cells or Engelbreth-Hohn-Swarm tumor cells (EUS), pure bovine kidney heparan...

..., a similar matrix, seen on cultured mesenchymal cells that were FD but not CPD, is the hydrated glycosaminoglycan, hyaluronic acid ( Bard et al . 1983 ). The stage-26 stroma lacks hyaluronic acid ( Toole & Trelstad, 1971 ), but contains chondroitin and heparan sulphates and possibly other proteoglycans...

... for chondrocranium morphogenesis. Specifically, the purpose of this study was (1) to determine the proportion of extracellular matrix (ECM) to cell area and total head mesenchymal area during chondrocranium morphogenesis; and (2) to identify the location, types, and relative amounts of glycosaminoglycans (GAG) being...

...R. P. Tucker ABSTRACT The migratory pathways of neural crest-derived pigment cells were examined in two anurans, Xenopus laevis and Discoglossus pictus , and correlated with the distribution of glycosaminoglycans (GAG) in the extracellular matrix (ECM) of these pathways. In Xenopus , melanophores...