..., required to overcome this inhibition. The inductive interaction is not required if the inhibitory signal is absent. Although the Notch receptor GLP-1 was implicated in both interactions, the molecular nature of the two signals was unknown. We now show that zygotically expressed MOM-2 (Wnt) is responsible...

.../GLP-1 control of hepatic glucose production. Overall, this study supports the hypothesis that alpha cells are an endogenous reservoir of potential new beta cells. It further reveals that glucagon plays an important role in maintaining endocrine cell homeostasis through feedback mechanisms that govern...

... contributed equally to this work 22 1 2004 © 2004. 2004 C. elegans GLP-1 Notch T-box Mesoderm Induction The Notch signaling pathway is widely conserved in animal development, and is used in an enormous variety of cell fate decisions (for a review, see Artavanis-Tsakonas et...

...Dave Hansen; Laura Wilson-Berry; Thanh Dang; Tim Schedl Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved...

... cells. * Author for correspondence (e-mail: [email protected] ) 31 05 1999 20 07 1999 © 2000 by Company of Biologists 2000 Left-right asymmetry Anterior-posterior asymmetry Intestinal organogenesis Notch signaling APX-1 GLP-1 LAG-1 LAG-2 LIN-12 LIT-1 POP-1...

...Caroline Goutte; William Hepler; Katherine M. Mickey; James R. Priess ABSTRACT In animal development, numerous cell-cell interactions are mediated by the GLP-1/LIN-12/NOTCH family of transmembrane receptors. These proteins function in a signaling pathway that appears to be conserved from nematodes...

... to specify the cell fate patterns made by individual blastomeres. Examples of such regulators of blastomere identity include the maternal proteins MEX-3 and GLP-1, expressed at high levels anteriorly, and SKN-1 and PAL-1, expressed at high levels posteriorly in early embryos. To better define par gene...

...Laura Wilson Berry; Bethany Westlund; Tim Schedl ABSTRACT Caenorhabditis elegans germ-line proliferation is controlled by an inductive interaction between the somatic distal tip cell and the germ line. GLP-1, a member of the Notch family of transmembrane receptors, is required continuously...

...Ivan P. G. Moskowitz; Joel H. Rothman ABSTRACT Cell-cell interactions mediated by LIN-12 and GLP-1, members of the LNG (LIN-12, Notch, GLP-1) family of receptors, are required to specify numerous cell fates during development of the nematode Caenorhabditis elegans . Maternally expressed GLP-1...

...-1 gene, which is similar in sequence to Drosophila Notch , supporting models in which GLP-1 protein acts as a receptor for both the P 2 and MS signals. We also show that P 2 signaling requires the activity of the apx-1 gene, similar in sequence to Drosophila Delta , and that MS signaling requires...

... P 2 signalling in wild-type embryos results in defects in ABp development that are similar to those caused by mutations in the glp-1 and apx-1 genes, which are homologs of the Drosophila genes Notch and Delta , respectively. Previous studies have shown that GLP-1 protein is expressed in 4-cell stage...

...Sioux Christensen; Voula Kodoyianni; Marcus Bosenberg; Lisa Friedman; Judith Kimble ABSTRACT The homologous receptors LIN-12 and GLP-1 mediate diverse cell-signaling events during development of the nematode Caenorhabditis elegans . These two receptors appear to be functionally interchangeable...

... substitute for endogenous lag-2 activity. Moreover, we provide evidence that these truncated forms are secreted and able to activate LIN-12 and GLP-1 ectopically. Finally, we show that expression of a secreted DSL domain alone may enhance endogenous LAG-2 signalling. Our data suggest ways that activated...

... as a result of their unique positions. One such difference is that the distribution of epidermal precursors arising from ABp is reversed along the anterior-posterior axis relative to those arising from ABa. We have found that a strong mutation in the glp-1 gene eliminates this ABa/ABp difference. Furthermore...

...Sarah L. Crittenden; Emily R. Troemel; Thomas C. Evans; Judith Kimble ABSTRACT In C. elegans , germline mitosis depends on induction by the somatic distal tip cell (DTC) and on activity of the glp-1 gene. Using antibodies to GLP-1 protein, we have examined GLP-1 on western blots...

...Samuel T. Henderson; Dali Gao; Eric J. Lambie; Judith Kimble ABSTRACT The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the receptors GLP-1 and LIN-12. In this paper, we report that lag-2 encodes a putative membrane protein with sequence similarity to Drosophila...

... interaction depends on glp-1 , a putative receptor for intercellular interactions. To investigate this early induction further, we isolated mutants in which ABp developed abnormally. We describe the effects of recessive mutations in apx-1 , a maternal gene that appears to be required for P 2 to signal ABp...

... of this duplication and divergence. In Caenorhabditis elegans , two lin-12/Notch genes, lin-12 and glp-1 , encode proteins that are 50% identical, with different numbers of epidermal growth factor-like motifs in their extracellular domains. Many of the cell fate decisions mediated by lin-12 and glp-1 are distinct...

...Eric J. Lambie; Judith Kimble ABSTRACT Two homologous genes, lin-12 and glp-1 , encode transmembrane proteins required for regulatory cell interactions during C. elegans development. Based on their single mutant phenotypes, each gene has been thought to govern a distinct set of cell fates. We show...

...Judith Austin; Eleanor M. Maine; Judith Kimble ABSTRACT Cell-cell interactions play a significant role in controlling cell fate during development of the nematode Caenorhabditis elegans . It has been found that two genes, glp-1 and lin-12 , are required for many of these decisions, glp-1...