...Tim J. Yeung; David G. Wilkinson ABSTRACT In the vertebrate nervous system, neurogenesis generally precedes gliogenesis. The mechanisms driving the switch in cell type production and generation of the correct proportion of cell types remain unclear. Here, we show that Fgf20 signalling patterns...

... involved in gliogenesis and is required for Müller glia production. We report that Ikzf4 regulates Notch signaling genes and is sufficient to activate the Hes1 promoter through two Ikzf GGAA-binding motifs, suggesting a mechanism by which Ikzf4 may influence gliogenesis. These results uncover...

... heterogeneity remains unclear. Here, we have dissected subpopulations of embryonic mouse forebrain progenitors using single-cell transcriptome analyses. Our sequencing data revealed two molecularly distinct APC subgroups at the start of gliogenesis from both dorsal and ventral forebrains. The two APC subgroups...

.... This raises an interesting possibility that glial precursors with distinct developmental fates exist that govern region-specific gliogenesis. Here, we have mapped the glial progeny produced by the Drosophila type II neuroblasts, which, like vertebrate radial glia cells, yield both neurons and glia via...

... factor essential for specification and differentiation of retinal Müller glia, also plays a crucial role in the development of retinal neurons. Overexpression of Lhx2 with its transcriptional co-activator Ldb1 triggers cell cycle exit and inhibits both Notch signaling and retinal gliogenesis. Lhx2 / Ldb1...

.... Previously, we found that the Hes genes inhibit neuronal differentiation and maintain NSCs. Here, we generated transgenic mice that overexpress Hes5 in NSCs of the central nervous system, and found that the transition timing from deep to superficial layer neurogenesis was shifted earlier, while gliogenesis...

... to increased progenitor cell numbers and affects cell fate choice in the developing mouse olfactory epithelium. Neurogenesis Gliogenesis Cellular differentiation Neogenin Olfactory epithelium RGM Mouse Organogenesis relies on the production of distinct cell types from stem/progenitor cells...

... foetal development. However, the molecular cues that instruct gliogenesis and determine glial cell type are poorly understood. During post-embryonic development, the number of glia in the Drosophila larval brain increases dramatically, potentially providing a powerful model for understanding gliogenesis...

... 2011 © 2011. Spinal cord Gliogenesis Tenascin C Extracellular matrix Growth factor responsiveness Neural patterning Astrocytes are the most abundant cell type in the adult central nervous system (CNS). Despite their various roles in CNS function and homeostasis...

... interests. 23 8 2011 © 2011. Hand2 ENS Neurogenesis Gliogenesis Neural precursor cell Neurotransmitter specification The enteric nervous system (ENS) comprises a network of neural crest-derived neurons that express a diverse array of neurotransmitters...

... Follistatin Gliogenesis Mouse For developing tissues to attain their proper size and cell type proportions, stem cell proliferation and differentiation must be tightly regulated. Recent studies have identified a variety of negative-feedback strategies for achieving robust control of tissue size...

.... In summary, our studies reveal that in the zebrafish hindbrain, FGF-receptor signalling specifies SMNs and OLPs by promoting olig2 expression, and supports gliogenesis, by promoting sox9 expression ( Fig. 7 ). Ventrally, FGF-receptor signalling cooperates with the Shh pathway to control olig2...

... than previously thought. † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally 14 9 2007 © 2007. 2007 TrkB TrkC BDNF Neurogenesis Gliogenesis Self-renewal Cortical precursors Neural stem cells In utero electroporation Akt...

...Merritt K. Taylor; Kelly Yeager; Sean J. Morrison Constitutive activation of the Notch pathway can promote gliogenesis by peripheral (PNS) and central (CNS) nervous system progenitors. This raises the question of whether physiological Notch signaling regulates gliogenesis in vivo. To test this, we...

... in Xenopus,XHes2 , as a regulator to bias retinal precursor cells towards a glial fate. XHes2 expression is predominantly restricted to sensory organ territories, including the retina. Using in vivo lipofection in the optic vesicle, we found that XHes2 overexpression dramatically increases gliogenesis...

... stem cell development. † Author for correspondence (e-mail: [email protected] ) * Present address: INSERM U646, 10 rue André Boquel, F-49100 Angers,France 24 3 2004 © 2004. 2004 Tenascin C Growth factor Proliferation Differentiation Neurogenesis Gliogenesis...

.... A recent report showed that in the adult bristle lineage, gcm expression is negatively regulated by Notch signaling ( Van De Bor, V. and Giangrande, A. ( 2001 ). Development 128 , 1381 -1390 ). Here we show that the effect of Notch activation on gliogenesis is context-dependent. In the dorsal bipolar...

...-repressing proneural genes like Xngnr-1 , Xath5 , Xath3 and NeuroD . These studies strongly suggest that in this system, activation but not inactivation of the Notch pathway using XSu(H) constructs, drives retinal precursors out of the cells cycle prematurely. Neurogenesis Gliogenesis Cell...

... of gliogenesis in peripheral ganglia of Sox10 +/– embryos. There is ample evidence that the regulation of the correct neuronal cell number involves programmed cell death both in a target-dependent ( Deshmukh and Johnson, 1997 ) and possibly target-independent manner ( Hagedorn et al., 2000a ; Raoul et al...

... Biology, Building 37 Room 6066, NIH, Bethesda, MD 20892-4255, USA. Author for correspondence (e-mail: [email protected] ) 19 7 2001 © 2001. 2001 Tramtrack gliogenesis Drosophila CNS The development and correct functioning of the nervous systems of all higher...