... of Biologists 1996 Caenorhabditis elegans hypodermis glial cells cell fate asymmetric cell division transcription factor LIN-26 How cell fates are specified is a basic problem in developmental biology. We recently proposed that, in C. elegans , the gene lin-26 is required to specify...

... of glia function. It is not, however, required for the initial determination of glial cells. In the embryo, the gene, which encodes a homeodomain protein, is expressed exclusively in all developing glia and closely related cells in both the central and peripheral nervous systems. The only observed...

... and optic nerve. * Author for correspondence 12 03 1993 © 1993 by Company of Biologists 1993 PDGF PDGF receptors retina optic nerve neurons glial cells blood vessels in situ hybridization immunohistochemistry rat mouse Many polypeptide growth factors are expressed...

...Angela Giangrande; Marjorie A. Murray; John Palka ABSTRACT We have used enhancer trap lines as markers to recognize glial cells in the wing peripheral nervous system of Drosophila melanogaster . Their characterization has enabled us to define certain features of glial differentiation...

... (beneath the foramen of Monro). Our data demonstrate that gene expression and cell fate can be regulated with exquisite spatial resolution along the dorsoventral axis of the mammalian neural tube. 26 10 1992 © 1993 by Company of Biologists 1993 PDGF receptors rat CNS glial cells...

...Margaret L. Winberg; Sharon E. Perez; Hermann Steller ABSTRACT We have examined the generation and development of glial cells in the first optic ganglion, the lamina, of Drosophila melanogaster . Previous work has shown that the growth of retinal axons into the developing optic lobes induces...

...- α R mRNA appears to be expressed by a subset of glial cells, but not by neurons. The temporal and spatial distribution of PDGF- α R + cells, together with 125 I-PDGF binding studies on subsets of glial cells in vitro, suggests that PDGF- α R may be expressed predominantly, or exclusively, by cells...

...Alexander R. Johnston; Douglas J. Gooday ABSTRACT Nasal and temporal retinal neurites were confronted in culture with glial cells from the rostral and caudal parts of the optic tectum and with glial cells from the diencephalon. Twenty of each of the six classes of encounter between individual...

..., can be found in vivo is not known. Even with the advent of antibodies as cell-specific markers the major difficulty in all of these studies remains the identification of dividing and immature glial cells and the extrapolation from development in culture to development in vivo . In a recent study...