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Keywords: germ cells
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Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2022) 149 (1): dev200089.
Published: 10 January 2022
... are facilitated by INO80 in coordination with H2A.Z and SUZ12 to establish poised chromatin. INO80 Poised chromatin Chromatin remodeler Germ cells Polycomb subunits Spermatogenesis National Institutes of Health R01GM101974 Lalor Foundation http://dx.doi.org/10.13039/100012756...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (12): dev198010.
Published: 18 June 2021
... selectable markers [tissue-specific expression of fluorescent proteins (FPs)] and that express target guide RNAs ubiquitously (U6 promoter) and Cas9 from germline promoters [ bucky ball (female meiotic cells) ( Heim et al., 2014 ) and ziwi (all germ cells) ( Leu and Draper, 2010 ); Fig. 1 A,B, Fig. S1...
Includes: Supplementary data
Journal Articles
In collection:
Reproductive biology
Journal: Development
Development (2021) 148 (9): dev197111.
Published: 28 April 2021
...Nicholas J. Webster; Rebecca L. Maywald; Susan M. Benton; Emily P. Dawson; Oscar D. Murillo; Emily L. LaPlante; Aleksandar Milosavljevic; Denise G. Lanza; Jason D. Heaney ABSTRACT In response to signals from the embryonic testis, the germ cell intrinsic factor NANOS2 coordinates a transcriptional...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2021) 148 (6): dev189217.
Published: 15 March 2021
...Grace V. Hancock; Sissy E. Wamaitha; Lior Peretz; Amander T. Clark ABSTRACT The peri-implantation window of mammalian development is the crucial window for primordial germ cell (PGC) specification. Whereas pre-implantation dynamics are relatively conserved between species, the implantation window...
Journal Articles
Journal: Development
Development (2021) 148 (1): dev191916.
Published: 11 January 2021
...Danelle Wright; Makoto Kiso; Yumiko Saga ABSTRACT NANOS2 and NANOS3 are evolutionarily conserved RNA-binding proteins involved in murine germ cell development. NANOS3 is required for protection from apoptosis during migration and gonadal colonization in both sexes, whereas NANOS2 is male-specific...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (17): dev191528.
Published: 11 September 2020
.... Subclustering of these major embryonic domains revealed over 50 cell states with distinct transcript profiles. Furthermore, we identified the transcript profile of two cell states expressing germ cell factors, one we conclude represents the primordial germ cells and the other state is transiently present during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (8): dev184259.
Published: 12 April 2020
..., which may underlie their similar behavior during both differentiation and dedifferentiation processes. Finally, distinct differentiating germ cell cyst samples do not exhibit obvious dosage compensation of X-chromosomal genes, even considering the paucity of X-chromosomal gene expression during meiosis...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev175950.
Published: 25 July 2019
...Victor A. Ruthig; Matthew B. Friedersdorf; Jason A. Garness; Steve C. Munger; Corey Bunce; Jack D. Keene; Blanche Capel ABSTRACT The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day (E)10.5. PGCs undergo...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (17): dev161786.
Published: 07 September 2018
... sequences and, accordingly, functions for piRNAs and PIWI proteins that are independent of TE regulation have been identified. This aspect of piRNA biology is expanding rapidly. Indeed, recent reports have revealed the role of piRNAs in the regulation of endogenous gene expression programs in germ cells...
Journal Articles
Journal: Development
Development (2018) 145 (10): dev161042.
Published: 14 May 2018
... phase and an efficient S phase, permitting the continuous proliferation of GSCs for gamete production. GSK3β Cell cycle Germ cells Stem cell proliferation Stem cells sustain tissue development and growth, and maintain tissue homeostasis by balancing the rates of proliferation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (7): dev163949.
Published: 29 March 2018
... cells of the germline. Germ cells Meiosis Caenorhabditis elegans pas-1 rpn-1 htp-3 Sexual reproduction depends on the formation of haploid gametes from diploid parent cells. This reduction in ploidy requires accurate segregation of homologous chromosomes (homologs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (6): dev156612.
Published: 15 March 2018
...Emily P. Dawson; Denise G. Lanza; Nicholas J. Webster; Susan M. Benton; Isao Suetake; Jason D. Heaney Testicular teratomas result from anomalies in embryonic germ cell development. In 129 inbred mice, teratoma initiation coincides with germ cell sex-specific differentiation and the mitotic-meiotic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2016) 143 (17): 3097–3108.
Published: 01 September 2016
... that facilitates the membrane localization of GLP-1 /Notch. Self-renewal Differentiation STRIPAK Far complex Germ cells Next, we tested the effect of farl-11(kp35) on the phenotype of glp-1(q231) , which is a temperature-sensitive loss-of-function ( lf ) allele. Adults homozygous for glp-1(q231...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2015) 142 (21): 3791–3800.
Published: 01 November 2015
.../j.exer.2008.10.011 Ichijima , Y. , Ichijima , M. , Lou , Z. , Nussenzweig , A. , Camerini-Otero , R. D. , Chen , J. , Andreassen , P. R. and Namekawa , S. H. ( 2011 ). MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells . Genes Dev...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3561–3571.
Published: 15 September 2014
... to program primordial germ cells to undergo spermatogenesis. Fibroblast growth factor 9 and several members of the transforming growth factor β superfamily are involved in this process in the foetal testis, counteracting the induction of meiosis by retinoic acid and activating germinal mitotic arrest. Here...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (18): 3483–3494.
Published: 15 September 2014
... as abnormal sperm and testes morphology. Additionally, null germ cell populations at specific stages in spermatogenesis, in particular spermatocytes and spermatogonia, exhibited increased rates of apoptosis. Disruption of H3f3b also altered histone post-translational modifications and gene expression...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (20): 4145–4154.
Published: 15 October 2013
... . Tor and InR are required cell-autonomously for the proliferation of precursors for both somatic niches and GSCs. These pathways also promote the formation of terminal filaments (part of the somatic niche). Significantly, InR, but not Tor, signaling non-autonomously promotes primordial germ cell (PGC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (17): 3565–3576.
Published: 01 September 2013
... for differentiation of murine spermatogonia toward meiosis. We have exploited a property of incomplete cytokinesis, which causes male germ cells to form aligned chains of characteristic lengths, as they divide and differentiate. These chains revealed the stage of spermatogenesis, so the epigenetic differences...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (8): 1645–1654.
Published: 15 April 2013
...Samir Vaid; Mohd Ariz; Amaresh Chaturbedi; Ganga Anil Kumar; Kuppuswamy Subramaniam Signals that promote germ cell self-renewal by preventing premature meiotic entry are well understood. However, signals that control mitotic proliferation to promote meiotic differentiation have not been well...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2013) 140 (6): 1312–1320.
Published: 15 March 2013
... forms increase by ∼2- to 3-fold compared with the wild type. These two proteins colocalise at the inner nuclear periphery, and their absence leads to reduced germ cell proliferation and to sterility. A yeast two-hybrid screen of 31 components of the nuclear pore complex and mRNA processing machineries...
Includes: Supplementary data