... neural stem cells (NSCs) with unique properties and growth requirements. Adult NSCs constitute a reversibly quiescent cell population that can be activated by extracellular signals from the microenvironment in which they reside in vivo . Although genomic imprinting plays a role in adult neurogenesis...

... Methylcytosine dioxygenase Genomic imprinting DNA methylation Epigenetic reprogramming Allele-specific expression Imprinting control region (ICR) Mouse National Institutes of Health 10.13039/100000002 R37GM051279 T32GM008216 F31GM119271 A major factor in determining developmental...

... - 2834 . 10.1093/humrep/den310 Barlow , D. P. and Bartolomei , M. S. ( 2014 ). Genomic imprinting in mammals . Cold Spring Harb. Perspect. Biol.   6 , 1 - 20 . 10.1101/cshperspect.a018382 Bartolomei , M. S. and Ferguson-Smith , A. C. ( 2011 ). Mammalian genomic...

...Emily Swanzey; Matthias Stadtfeld Genomic imprinting results in the monoallelic expression of genes that encode important regulators of growth and proliferation. Dysregulation of imprinted genes, such as those within the Dlk1-Dio3 locus, is associated with developmental syndromes and specific...

... muscle stem cell number and controls their entry into quiescence. Absence of H19 leads to better muscle regeneration with increased expression of the IGN genes. Satellite cells Quiescence Genomic imprinting Epigenetics Mouse The H19 gene produces an imprinted maternally expressed non...

...Hitomi Matsuzaki; Eiichi Okamura; Takuya Takahashi; Aki Ushiki; Toshinobu Nakamura; Toru Nakano; Kenichiro Hata; Akiyoshi Fukamizu; Keiji Tanimoto Genomic imprinting is a major monoallelic gene expression regulatory mechanism in mammals, and depends on gamete-specific DNA methylation of specialized...

.... Genomic imprinting Rtl1 (Peg11) miR-127 Mir127 Placenta development Mammalian genomic imprinting is an epigenetic process whereby genes are mono-allelically expressed in a parent-of-origin-specific manner ( Ferguson-Smith, 2011 ). The imprinted gene cluster on mouse chromosome 12 contains...

..., this is surprising as dosage compensation is not initiated and genomic imprinting appears to play a minor role ( Leeb and Wutz, 2012 ). In the short time since their discovery, haploid mammalian cells cultured in vitro have already contributed to gene discovery in the context of targeted forward genetics screens...

... . Neuropsychopharmacology 35 , 2450 – 2461 . Barlow D. P. ( 2011 ). Genomic imprinting: a mammalian epigenetic discovery model . Annu. Rev. Genet. 45 , 379 – 403 . Bartolomei M. S. , Ferguson-Smith A. C. ( 2011 ). Mammalian genomic imprinting . Cold Spring Harb. Perspect. Biol. 3...

... 2013. Published by The Company of Biologists Ltd Diaphragm differentiation Genomic imprinting Myogenesis In mammals, several myogenic regulatory factors (MRFs), such as Myf5, Mrf4 (Myf6), Myod and myogenin (Myog), are involved in skeletal muscle development. Myod1 ( Myod ), which...

... , 4 . Esteve P. O. , Chin H. G. , Pradhan S. ( 2005 ). Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters . Proc. Natl. Acad. Sci. USA 102 , 1000 - 1005 . Ferguson-Smith A. C. ( 2011 ). Genomic imprinting...

...Michael C. Golding; Lauren S. Magri; Liyue Zhang; Sarah A. Lalone; Michael J. Higgins; Mellissa R. W. Mann To understand the complex regulation of genomic imprinting it is important to determine how early embryos establish imprinted gene expression across large chromosomal domains. Long non-coding...

... imprinting Non-CpG methylation Oocyte Sperm Mouse Genomic imprinting is a parental origin-specific gene-marking phenomenon crucial for normal mammalian development. The marks, or imprints, render certain genes as expressed from only one of the two inherited chromosomes. At the molecular level...

... by maintaining active status of the IG-DMR. © 2010. Gtl2 Meg3 Dlk1-Gtl2 locus Genomic imprinting Mouse Methylation Muscle development The imprinted Dlk1-Gtl2 (delta like 1 homolog – gene trap locus 2) locus is approximately 1 Mb long and located on mouse distal...

.... Noncoding RNA Epigenetics Chromatin Genomic imprinting Kcnq1ot1 Genomic imprinting is an epigenetic phenomenon in mammals whereby the expression of a subset of autosomal genes is restricted to one of the parental chromosomes such that they are expressed either from the maternal...

... new perspectives in the comprehension of the role of genomic imprinting in embryonic growth and in human imprinting pathologies. * Author for correspondence( [email protected] ) 11 8 2009 © 2009. 2009 H19 Igf2 Transgenic mouse models Imprinted gene network (IGN...

...Paulina A. Latos; Stefan H. Stricker; Laura Steenpass; Florian M. Pauler; Ru Huang; Basak H. Senergin; Kakkad Regha; Martha V. Koerner; Katarzyna E. Warczok; Christine Unger; Denise P. Barlow Genomic imprinting is an epigenetic process that results in parental-specific gene expression. Advances...

...Shau-Ping Lin; Phil Coan; Simao Teixeira da Rocha; Herve Seitz; Jerome Cavaille; Pi-Wen Teng; Shuji Takada; Anne C. Ferguson-Smith Genomic imprinting is an epigenetic mechanism controlling parental-origin-specific gene expression. Perturbing the parental origin of the distal portion of mouse...

... and hence represent a common cause of the loss of germline potential. In addition to their chromosomal instability, in vitro culture of preimplantation embryo, ES cells and EG cells induces aberrant genomic imprinting, which can lead to morphological or functional abnormalities in embryo or offspring...

...Jiyoung Lee; Kimiko Inoue; Ryuichi Ono; Narumi Ogonuki; Takashi Kohda; Tomoko Kaneko-Ishino; Atsuo Ogura; Fumitoshi Ishino Genomic imprinting is an epigenetic mechanism that causes functional differences between paternal and maternal genomes, and plays an essential role in mammalian development...