.... This Review discusses the mechanisms that underlie the handover of developmental control to the zygotic genome during the maternal-to-zygotic transition. MZT Genome activation Maternal mRNAs Early animal development is controlled by maternal mRNAs and proteins that are loaded into the egg...

... reprogramming. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 15 6 2011 © 2011. Genome activation Human embryos Pluripotency Preimplantation development, which covers...

... is markedly reduced. We also present evidence that the transgene expression in vitro coincides with the onset of the embryonic genome activation as attested by the synthesis of the 70 ×10 3 M r protein complex. Therefore, this transgene expression could prove to be a useful tool in our understanding...