.... Little; Chad M. Vezina; Cathy Mendelsohn Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine...

...Congxing Lin; Yan Yin; G. Michael Veith; Alexander V. Fisher; Fanxin Long; Liang Ma Genital tubercle (GT) initiation and outgrowth involve coordinated morphogenesis of surface ectoderm, cloacal mesoderm and hindgut endoderm. GT development appears to mirror that of the limb. Although Shh...

... 2 2005 ©2005. 2005 Fgfr2-IIIb Tubular morphogenesis Hypospadias Urethral plate Genital tubercle Development of mammalian external genitalia requires tight coordination of proximodistal outgrowth, three-dimensional patterning and tubular morphogenesis. Malformations...

... growth and differentiation of the genital tubercle (GT), an embryonic anlage of external genitalia, generates a proximodistally elongated structure suitable for copulation, erection, uresis and ejaculation. Despite recent progress in molecular embryology, few attempts have been made to elucidate...

... growth factor 10 ( Fgf10 ), in the anlage: the genital tubercle (GT). Activities of Shh for both GT outgrowth and differentiation were also demonstrated. Shh –/– mice displayed complete GT agenesis, which is compatible with such observations. Furthermore, the regulation of apoptosis during GT formation...

... cavernosum penis. INTRODUCTION The penis of the rat possesses a skeletal system chiefly comprising the corpus cavernosum penis and the os penis. Mesenchymal cells in the genital tubercle of rat foetuses form the rudiment of the corpus cavernosum penis, the rudiment of the proximal segment (p-segment) of os...