...Alexis Garretson; Beth L. Dumont; Mary Ann Handel ABSTRACT Genetic analyses of mammalian gametogenesis and fertility have the potential to inform about two important and interrelated clinical areas: infertility and contraception. Here, we address the genetics and genomics underlying gamete...

... and the use of synthetic systems to test models. This highly dynamic, interdisciplinary mix of quantitative developmental genetics, bioengineering, synthetic biology and artificial life aimed to reveal how evolution exploits physical forces and genetics to implement the cell- and tissue-level decision-making...

... to proceed. Besides lineage specification, GATA factors also play crucial roles in the early stages of tissue morphogenesis. As expected for such important developmental regulators, most have been associated with deleterious genetic diseases in human. * These authors contributed equally to this work...

... leaflet maturation remains poorly understood. Here, we show in mouse that neural crest cells from pre-otic and post-otic regions make distinct contributions to the arterial valve leaflets. Genetic fate-mapping analysis of Krox20-expressing neural crest cells shows a large contribution to the borders...

... highlight additional Notch receptors or ligands that are likely to be involved in human genetic diseases. Based on these phenotypes seen in Jag2 mutant mice, it is tempting to speculate that human disorders involving syndactyly or cleft palate may involve JAG2 mutations. In fact, mutations in JAG2...

... showed reduced expression of multiple neuroretina-expressed FGFs and canonical FGF-regulated genes in neuroretina. When FGF expression was genetically restored in Lhx2 -deficient neuroretina of Chx10-Cre;Lhx2 lox/lox mice, we observed a partial but nonetheless substantial rescue of the defects in lens...

...: University of Virginia Health Systems, Department of Pathlogy, 415 Lane Road, Charlottesville, VA 22908, USA 29 12 2004 ©2005. 2005 Epiboly Radial intercalation E-cadherin Epiblast Teleost Morphogenesis Genetics Antisense Zebrafish Here we report on the molecular identity...

... ribosomal protein mutation. * Author for correspondence (e-mail: [email protected] ) 12 5 2004 ©2004. 2004 Mouse Genetics Minute Ribosome Cell cycle Retina Bst The Minutes are an intriguing group of eukaryotic mutations that have been valuable in elucidating...

... understood. To identify genes required for the formation of vertebrate digestive organs we performed a genetic screen in zebrafish. We isolated the nil per os ( npo ) mutation,which arrests morphogenesis and cytodifferentiation of the gut and exocrine pancreas in a primodial state. We identified the npo gene...

... 1996 uniparental duplication imprinting translocation mouse genetics chromosome 7 Imprinting of the mammalian genome has been demonstrated experimentally in the developmental failure of (1) mouse embryos with two maternal or two paternal genomes, termed parthenogenones (PG...

... causing loss of paternal chromosomes . Genetics 80 , 268 – 296 . Banerjee , U. and Zipursky , S. L. ( 1990 ). The role of cell-cell interaction in the development of the Drosophila visual system . Neuron 4 , 177 – 187 . 10.1016/0896-6273(90)90093-U Beato , M...

.../oxfordjournals.jhered.a103275 Geissler , E. N. , Cheng , S. V. , Gusella , J. F. and Housman , D. E. ( 1988 ). Genetic analysis of the dominant white spotting (IF) region on mouse chromosome 5: Identification of cloned DNA markers near W . Proc. Natl. Acad. Sci. USA 85 , 9635 – 9639 . 10.1073...

... the neurons and their axonal paths occur at close range and involve multiple, possibly combinatorial, transmitterindependent pathways. Copyright © 1991 by Company of Biologists 1991 genetics mutation zebrafish primary neuron notoneuron somite muscle notochord floor plate cell nteractions...

...Dorothy C. Bennett; Dennis Huszar; Philip J. Laipis; Rudolf Jaenisch; Ian J. Jackson ABSTRACT A mouse cDNA for the developmentally controlled, melanocyte-specific protein, tyrosinase-related protein 1 (TRP-1), was previously cloned and reported to show genetic linkage with the coat-colour locus...

.... ( 1985 ). Plasticity of the differential state . Science 230 , 758 – 766 . 10.1126/science.2414846 Brenner , S. ( 1974 ). The genetics of C. elegans. Genetics 77 , 71 – 94 . Cowan , A. E. and McIntosh , J. R. ( 1985 ). Mapping the distribution of differentiation...

... the body wall. 24 03 1987 © 1987 by Company of Biologists 1987 Caenorhabditis elegans neurone migration genetics cell lineage axon Cells assemble into organs by selectively attaching to neighbouring cells. In animals, the final neighbours need not be close relatives...