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Keywords: gene regulation
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Journal Articles
Journal: Development
Series: REVIEW COMMONS TRANSFER
Development (2024) 151 (9): dev202525.
Published: 9 May 2024
.... Summary: Although Prox1 is a key factor in lymphatic endothelial cell development, little is known about its cis -regulation. Here, we characterise multiple prox1a enhancers active in subsets of zebrafish lymphatic vasculature. Prox1 Enhancers Evolutionary conservation Gene regulation...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2024) 151 (1): dev201986.
Published: 2 January 2024
... activation, with a reduced impact of activators under conditions of reduced metabolism. Drosophila Gene regulation Metabolism National Institutes of Health http://dx.doi.org/10.13039/100000002 GM118144 National Science Foundation http://dx.doi.org/10.13039/100000001...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2023) 150 (24): dev202284.
Published: 11 December 2023
.... Caenorhabditis elegans RNAi Gene regulation Germ granules Nuage Small RNAs National Institutes of Heath R35 GM119656 Pew Charitable Trusts http://dx.doi.org/10.13039/100000875 National Science Foundation http://dx.doi.org/10.13039/100000001 DGE 1418060...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2022) 149 (12): dev200594.
Published: 30 June 2022
...Aurélie Hintermann; Isabel Guerreiro; Lucille Lopez-Delisle; Christopher Chase Bolt; Sandra Gitto; Denis Duboule; Leonardo Beccari ABSTRACT Modifications in gene regulation are driving forces in the evolution of organisms. Part of these changes involve cis- regulatory elements (CREs), which contact...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2022) 149 (3): dev200250.
Published: 11 February 2022
... Forschungsgemeinschaft http://dx.doi.org/10.13039/501100001659 TI 799/1-3 Cortical development Neurogenesis Epigenetics Genomics Gene regulation Transcription factors Summary: How the functional cooperativity of Tcf12 and NeuroD1 in specific subpopulations of the developing cortex creates...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2021) 148 (9): dev182667.
Published: 29 April 2021
...Ersin Akinci; Marisa C. Hamilton; Benyapa Khowpinitchai; Richard I. Sherwood ABSTRACT Understanding how genes are expressed in the correct cell types and at the correct level is a key goal of developmental biology research. Gene regulation has traditionally been approached largely through...
Journal Articles
Journal: Development
Development (2020) 147 (21): dev194233.
Published: 21 October 2020
... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...
Journal Articles
Journal: Development
Development (2020) 147 (19): dev161430.
Published: 5 October 2020
... in the context of embryogenesis, covering their formation, physical properties, functions in gene regulation and how they could facilitate the evolution of regulatory elements. Gene regulation Development Nucleus Transcription factors Transcriptional microenvironment In 1968, the geneticist...
Journal Articles
Journal: Development
Development (2020) 147 (12): dev175059.
Published: 19 June 2020
... development and evolution. Lateral plate mesoderm Cardiovascular system Cell fate Development Evolution Gene regulation During gastrulation in vertebrates, the mesoderm forms axial, paraxial and lateral domains that harbor precursor cells for distinct organ systems. The lateral plate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev175141.
Published: 11 June 2020
... ). Biochemical fractionation showed that Cdk8 is localized to the nucleus in ESCs and can be detected in the chromatin-associated fraction ( Fig. 1 H), which is consistent with its function in gene regulation. Fig. 1. Loss of Cdk8 impairs X-linked gene silencing by Xist . (A) Schematic of the Xist...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (6): dev181909.
Published: 16 March 2020
... in the same cells to respond to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila Cis -regulatory regions such as enhancers and promoters interpret multiple types of inputs...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (3): dev171736.
Published: 3 February 2020
... and the techniques that can be used to study them. Regulatory landscape Gene regulation Topologically associating domains Enhancer-promoter interactions Pleiotropy Neo-functionalization Animal development provides an excellent system in which to study the mechanisms of gene transcription...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185314.
Published: 9 December 2019
...Matthew R. George; Qiming Duan; Abigail Nagle; Irfan S. Kathiriya; Yu Huang; Kavitha Rao; Saptarsi M. Haldar; Benoit G. Bruneau ABSTRACT Long intergenic non-coding RNAs (lincRNAs) have been implicated in gene regulation, but their requirement for development needs empirical interrogation. We...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (19): dev177162.
Published: 26 September 2019
...Elizabeth Ing-Simmons; Juan M. Vaquerizas ABSTRACT The three-dimensional organisation of the genome plays a crucial role in developmental gene regulation. In recent years, techniques to investigate this organisation have become more accessible to labs worldwide due to improvements in protocols...
Journal Articles
Journal Articles
Journal: Development
Development (2019) 146 (19): dev181180.
Published: 20 September 2019
... that H3K9me3 deposition requires protein SUMOylation in different contexts, suggesting that the SUMO pathway functions as an important module in gene silencing and heterochromatin formation. In this Review, we discuss the role of H3K9me3 in gene regulation in various systems and the molecular mechanisms...
Journal Articles
Journal: Development
Development (2019) 146 (18): dev181339.
Published: 19 September 2019
... the cochlea for sensory development. Cochlea Organ of Corti Otic vesicle Sensory development Gene regulation Shh signaling Mouse The organ of Corti is a specialized sensory structure for hearing in mammals that lines the length of the cochlear duct. It comprises a single row of inner hair...
Includes: Supplementary data