...Anna Nordin; Gianluca Zambanini; Mattias Enar Jonasson; Tamina Weiss; Yorick van de Grift; Pierfrancesco Pagella; Claudio Cantù ABSTRACT Gene regulators physically associate with the genome, in a combinatorial fashion, to drive tissue-specific gene expression. Uncovering the genome-wide activity...

... for gene regulation during zebrafish heart regeneration. We report that an enhancer is rewired from expression in a distal cardiac domain to activate a different gene in regenerating tissue. * These authors contributed equally to this work Author for correspondence ( [email protected]...

... regulation during the development of holometabolous insects, in particular Drosophila melanogaster . Conversely, functional genomics resources and databases in other insect lineages are scarce. To provide a new platform to study gene regulation in insects, we generated ATAC-seq for the first time during...

... of developmental and synthetic biological circuits. Cell fate decision Dynamical systems Gene regulation Landscape Mathematical modelling Tempo Imperial College London http://dx.doi.org/10.13039/501100000761 Leverhulme Trust http://dx.doi.org/10.13039/501100000275 RPG-2023-085...

... , 311 - 318 . 10.1038/ng1966 Hobert , O. ( 2010 ). Gene regulation: enhancers stepping out of the shadow . Curr. Biol. 20 , R697 - R699 . 10.1016/j.cub.2010.07.035 Hogan , B. M. , Bos , F. L. , Bussmann , J. , Witte , M. , Chi , N. C. , Duckers , H. J...

... metabolism. Drosophila Gene regulation Metabolism National Institutes of Health http://dx.doi.org/10.13039/100000002 GM118144 National Science Foundation http://dx.doi.org/10.13039/100000001 1764421 Simons Foundation http://dx.doi.org/10.13039/100000893...

... National Science Foundation http://dx.doi.org/10.13039/100000001 DGE 1418060 Pew Charitable Trusts http://dx.doi.org/10.13039/100000875 National Institutes of Heath R35 GM119656 Caenorhabditis elegans RNAi Gene regulation Germ granules Nuage Small RNAs...

... in mole ovotestis development, through regulatory changes that occur despite a striking conservation of TAD organization. This highlights the multilayered nature of gene regulation and how changes at different levels may serve as a driving force for the evolution of traits. Adult, infant...

...Aurélie Hintermann; Isabel Guerreiro; Lucille Lopez-Delisle; Christopher Chase Bolt; Sandra Gitto; Denis Duboule; Leonardo Beccari ABSTRACT Modifications in gene regulation are driving forces in the evolution of organisms. Part of these changes involve cis- regulatory elements (CREs), which contact...

.... Summary: How the functional cooperativity of Tcf12 and NeuroD1 in specific subpopulations of the developing cortex creates the gene regulatory program essential for neuronal migration. Cortical development Neurogenesis Epigenetics Genomics Gene regulation Transcription factors...

... and detection optics, localization and tracking algorithms, and data analysis. Finally, we provide a summary of selected recent applications of SMT to study the dynamics of gene regulation. * These authors contributed equally to this Review; their order was determined by a coin toss ‡ Author...

...Ersin Akinci; Marisa C. Hamilton; Benyapa Khowpinitchai; Richard I. Sherwood ABSTRACT Understanding how genes are expressed in the correct cell types and at the correct level is a key goal of developmental biology research. Gene regulation has traditionally been approached largely through...

... into the development of the heart have led to fundamental new concepts in gene regulation, but also to genetic and mechanistic insights into congenital heart defects. In more recent years, the lessons learned from studying heart development have been applied to interrogating regeneration of the diseased heart...

..., physical properties, functions in gene regulation and how they could facilitate the evolution of regulatory elements. Gene regulation Development Nucleus Transcription factors Transcriptional microenvironment In 1968, the geneticist David E. Comings discussed ‘the rationale behind...

... , S. , Vendrell , E. , Gibson-Brown , J. J. and Logan , M. P. O. ( 2012 ). Hox genes regulate the onset of Tbx5 expression in the forelimb . Development   139 , 3180 - 3188 . 10.1242/dev.084814 Monahan-Earley , R. , Dvorak , A. M. and Aird , W. C. ( 2013...

... Cells   12 , 119 - 132 . 10.1111/j.1365-2443.2007.01036.x Galupa , R. and Heard , E. ( 2018 ). X-chromosome inactivation: a crossroads between chromosome architecture and gene regulation . Annu. Rev. Genet.   52 , 535 - 566 . 10.1146/annurev-genet-120116-024611 Gobert...

... in the same cells to respond to spatial cues through regulation of chromatin accessibility. Temporal transcription factor Chromatin accessibility Enhancer Gene regulation Ecdysone Drosophila National Institutes of Health T32GM007092 National Science Foundation 10.13039...

... and the techniques that can be used to study them. Regulatory landscape Gene regulation Topologically associating domains Enhancer-promoter interactions Pleiotropy Neo-functionalization European Research Council 10.13039/100010663 232 790 National Institute of Child Health and Human...

...Matthew R. George; Qiming Duan; Abigail Nagle; Irfan S. Kathiriya; Yu Huang; Kavitha Rao; Saptarsi M. Haldar; Benoit G. Bruneau ABSTRACT Long intergenic non-coding RNAs (lincRNAs) have been implicated in gene regulation, but their requirement for development needs empirical interrogation. We...