... suppression of Wnt/β-catenin signaling, but the mechanism for this is not well understood. By analyzing gene expression and chromatin dynamics during directed differentiation of human embryonic stem cells (hESCs), we identified a suppressor of Wnt/β-catenin signaling, transmembrane protein 88 (TMEM88...

...Patrick Chomez; Isabelle Neveu; Anethe Mansén; Eva Kiesler; Lars Larsson; Björn Vennström; Ernest Arenas ABSTRACT The rev-erbA α gene, belonging to the steroid receptor superfamily of transcription factors, is highly conserved during evolution but little is known so far about its functions...

... of downstream genes. The Suppressor of Hairless protein is the intermediary between Notch activation and expression of all Enhancer of split genes even though individual genes have distinct patterns of expression in imaginal discs. A comparison between the phenotypes produced by Notch, Suppressor of Hairless...

...Stephen J. Gaunt ABSTRACT We showed earlier ( Gaunt, Miller, Powell & Duboule, 1986 ) that the mouse homoeobox gene Hox-1 . 5 is expressed in posterior ectoderm and mesoderm of and -day embryos, and in the -day nervous system posterior to a discrete boundary within the hindbrain. In further...