...) and their tissue inhibitors (TIMPs) was tissue-specific with little or no expression in the epithelium of tooth buds, tongue or oral cavity. Gelatinase A mRNA transcripts were strongly expressed in the perichondrium of Meckel’s cartilage and mesenchymal areas of embryonic day 13-15 mandibles, whereas gelatinase B...

... not inhibit all of the caseinases. Urokinase was also secreted. Addition of TIMP at 5·500 nM effectively inhibited the degradation of matrix by the trophoblast outgrowths. Blocking antibodies directed against 92 × 10 3 M r gelatinase abolished matrix degradation by the trophoblast cells. These observations...

... during the different stages of mammary development. Mammary tissue extracts from virgin and pregnant CD-I mice resolved by zymography contained three major proteinases of 60K (K=10 3 M r ), 68K and 70K that degraded denatured collagen. These three gelatinases were completely inhibited by the tissue...