... GATA1/2/3 LMO2 ese gcm Pigment cells Blastocoelar cells In addition to Nodal, BMP2/4 also appears to play an important role in patterning of the SMC precursors in the sea urchin embryo. However, unlike in vertebrates, in the sea urchin BMP2/4 signalling is not a positive regulator...

...Jenifer C. Croce; David R. McClay Endomesoderm is the common progenitor of endoderm and mesoderm early in the development of many animals. In the sea urchin embryo, the Delta/Notch pathway is necessary for the diversification of this tissue, as are two early transcription factors, Gcm and FoxA...

... (GCM) and GCM2 control plasmatocyte development, whereas the RUNX factor Lozenge (LZ) is required for crystal cell differentiation. We have investigated the segregation process that leads to the formation of these two cell types, and the interplay between LZ and GCM/GCM2. We show that,surprisingly, gcm...

...Yoshihiro Yuasa; Masataka Okabe; Shingo Yoshikawa; Katsuhiko Tabuchi; Wen-Cheng Xiong; Yasushi Hiromi; Hideyuki Okano In Drosophila , cell-fate determination of all neuroectoderm-derived glial cells depends on the transcription factor Glial cells missing (GCM), which serves as a binary switch...

... not affect final axonal patterning and connectivity. However, under these conditions, glial cells do not fragment but leave the epithelium by a mechanism that is reminiscent of cell competition. Finally, we present evidences showing that glial cells are committed to apoptosis independently of gcm...

...Yoshihiko Umesono; Yasushi Hiromi; Yoshiki Hotta During Drosophila neurogenesis, glial differentiation depends on the expression of glial cells missing ( gcm ). Understanding how glial fate is achieved thus requires knowledge of the temporal and spatial control mechanisms directing gcm expression...

...Marc R. Freeman; Chris Q. Doe In many organisms, single neural stem cells can generate both neurons and glia. How are these different cell types produced from a common precursor? In Drosophila , glial cells missing ( gcm ) is necessary and sufficient to induce glial development in the CNS. gcm mRNA...

... of glia on follower trajectories. In fact, mosaic glial ablation may be bypassed by extending axons, as mosaic neuronal ablation is ( Bastiani et al., 1986 ). Consequently, ablation of all longitudinal glia could lead to a more severe phenotype than the one that we observe. Similarly, gcm mutations do...

... lateral glial development is controlled by the gcm gene. Subsequent glial cell differentiation depends partly on the pointed gene. Here we describe a novel component required for all CNS glia development. The tramtrack gene encodes two zinc-finger proteins, one of which, ttkp69, is expressed in all non...