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Keywords: gbx2
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Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
..., UK), Gdf7 ( Broom et al., 2012 ), Gbx2 ( Kiecker and Lumsden, 2004 ), Fgf8 and Sprouty2 ( Chambers et al., 2000 ); and mouse probes for: Atoh1 (Albert Basson, King’s College London, UK), Lhx9 and Tbr1 (Alessio Delogu, King’s College London, UK). Following in situ hybridisation, GFP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 725–734.
Published: 15 February 2011
...N. Abimbola Sunmonu; Kairong Li; Qiuxia Guo; James Y. H. Li In vertebrates, the common expression border of two homeobox genes, Otx2 and Gbx2 , demarcates the prospective midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation. The presence of a compartment boundary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3267–3278.
Published: 1 October 2009
...Bo Li; Sei Kuriyama; Mauricio Moreno; Roberto Mayor Wnt signalling is required for neural crest (NC) induction; however, the direct targets of the Wnt pathway during NC induction remain unknown. We show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1317–1326.
Published: 15 April 2009
...Li Chen; Qiuxia Guo; James Y. H. Li Relatively little is known about the development of the thalamus,especially its differentiation into distinct nuclei. We demonstrate here that Gbx2 -expressing cells in mouse diencephalon contribute to the entire thalamic nuclear complex. However, the neuronal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2905–2916.
Published: 1 September 2008
... in the mutant. We found a Dlx-regulated transcriptional enhancer in close proximity to Gbx2 , one of the Dlx5/6 -downstream genes, strongly suggesting that Gbx2 is a direct target of Dlx5/6 . We also showed that Pou3f3 is normally expressed in the maxillary (prospective upper jaw) but not mandibular arch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 1991–2000.
Published: 15 May 2006
...Samuel T. Waters; Mark Lewandoski Gbx2 is a homeobox gene that plays a crucial role in positioning the mid/hindbrain organizer (isthmus), which regulates midbrain and cerebellar development primarily through the secreted factor FGF8. In Gbx2 null homozygotes, rhombomeres (r) 1-3 fail to develop...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2309–2318.
Published: 15 May 2005
...Zhengshi Lin; Raquel Cantos; Maria Patente; Doris K. Wu Gbx2 is a homeobox-containing transcription factor that is related to unplugged in Drosophila. In mice, Gbx2 and Otx2 negatively regulate each other to establish the mid-hindbrain boundary in the neural tube. Here, we show that Gbx2...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1971–1981.
Published: 15 April 2005
...James Y. H. Li; Zhimin Lao; Alexandra L. Joyner The mouse homeobox gene Gbx2 is first expressed throughout the posterior region of the embryo during gastrulation, and becomes restricted to rhombomeres 1-3 (r1-3) by embryonic day 8.5 (E8.5). Previous studies have shown that r1-3 do not develop...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1261–1272.
Published: 15 March 2005
... 1 2005 ©2005. 2005 Midbrain-hindbrain boundary MHB/isthmic organizer Posteriorization Zebrafish Neural plate Morphogen wnt8 gbx1 otx2 gbx2 nodal fgf The initial subdivision of the neural plate is the first step towards generating cellular diversity...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2001) 128 (23): 4789–4800.
Published: 1 December 2001
... Otx2 and Gbx2 . In order to provide novel insights into the roles of Otx2 and Gbx2 , we have studied mutant embryos carrying different dosages of Otx2 , Otx1 and Gbx2 . Embryos deficient for both OTX2 and GBX2 proteins ( hOtx1 2 /hOtx1 2 ; Gbx2 –/– ) show abnormal patterning of the anterior neural...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4165–4176.
Published: 1 November 2001
... differentiation in the midbrain and anterior hindbrain. Formation of this organizing center involves multiple steps, including positioning of the MHB within the neural plate, establishment of the organizer and maintenance of its regional identity and signaling activities. Juxtaposition of the Otx2 and Gbx2...