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Keywords: gbx2
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Journal Articles
Journal: Development
Development (2014) 141 (2): 389–398.
Published: 15 January 2014
... of this construct in chick through electroporation at E2 into the midbrain-hindbrain region. Ectopic dn-fgfr3c was sufficient to ablate Sprouty2 expression at the isthmus at E3 ( supplementary material Fig. S1A -C) and induce a caudal expansion of Otx2 -positive midbrain tissue at the expense of Gbx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (4): 725–734.
Published: 15 February 2011
...N. Abimbola Sunmonu; Kairong Li; Qiuxia Guo; James Y. H. Li In vertebrates, the common expression border of two homeobox genes, Otx2 and Gbx2 , demarcates the prospective midbrain-hindbrain border (MHB) in the neural plate at the end of gastrulation. The presence of a compartment boundary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (19): 3267–3278.
Published: 1 October 2009
...Bo Li; Sei Kuriyama; Mauricio Moreno; Roberto Mayor Wnt signalling is required for neural crest (NC) induction; however, the direct targets of the Wnt pathway during NC induction remain unknown. We show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (8): 1317–1326.
Published: 15 April 2009
...Li Chen; Qiuxia Guo; James Y. H. Li Relatively little is known about the development of the thalamus,especially its differentiation into distinct nuclei. We demonstrate here that Gbx2 -expressing cells in mouse diencephalon contribute to the entire thalamic nuclear complex. However, the neuronal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (17): 2905–2916.
Published: 1 September 2008
... in the mutant. We found a Dlx-regulated transcriptional enhancer in close proximity to Gbx2 , one of the Dlx5/6 -downstream genes, strongly suggesting that Gbx2 is a direct target of Dlx5/6 . We also showed that Pou3f3 is normally expressed in the maxillary (prospective upper jaw) but not mandibular arch...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (10): 1991–2000.
Published: 15 May 2006
...Samuel T. Waters; Mark Lewandoski Gbx2 is a homeobox gene that plays a crucial role in positioning the mid/hindbrain organizer (isthmus), which regulates midbrain and cerebellar development primarily through the secreted factor FGF8. In Gbx2 null homozygotes, rhombomeres (r) 1-3 fail to develop...
Journal Articles
Journal: Development
Development (2005) 132 (10): 2309–2318.
Published: 15 May 2005
...Zhengshi Lin; Raquel Cantos; Maria Patente; Doris K. Wu Gbx2 is a homeobox-containing transcription factor that is related to unplugged in Drosophila. In mice, Gbx2 and Otx2 negatively regulate each other to establish the mid-hindbrain boundary in the neural tube. Here, we show that Gbx2...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1971–1981.
Published: 15 April 2005
...James Y. H. Li; Zhimin Lao; Alexandra L. Joyner The mouse homeobox gene Gbx2 is first expressed throughout the posterior region of the embryo during gastrulation, and becomes restricted to rhombomeres 1-3 (r1-3) by embryonic day 8.5 (E8.5). Previous studies have shown that r1-3 do not develop...
Includes: Supplementary data
Journal Articles
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Journal Articles
Journal Articles
Journal: Development
Development (2001) 128 (2): 181–191.
Published: 15 January 2001
.../hindbrain genes that respond to FGF8, using a novel mouse brain explant culture system. We found that En2 and Gbx2 are the first genes to be induced by FGF8 in wild-type E9.5 diencephalic and midbrain explants treated with FGF8-soaked beads. By examining gene expression in En1/2 double mutant mouse embryos...
Journal Articles
Journal: Development
Development (1999) 126 (21): 4827–4838.
Published: 1 November 1999
..., but also can induce the hindbrain gene Gbx2 and alter the expression of Wnt1 in both midbrain and caudal forebrain explants. We also show that FGF8b- soaked beads can repress Otx2 in midbrain explants. Furthermore, Wnt1-Fgf8b transgenic embryos in which the same Wnt1 regulatory element is used to express...
Journal Articles
Journal: Development
Development (1999) 126 (18): 3981–3989.
Published: 15 September 1999
... tissues and involves a diffusible signal. * Author for correspondence (e-mail: i.mason@umds.ac.uk ) 19 06 1999 23 08 1999 © 1999 by Company of Biologists 1999 Isthmus Boundary Hindbrain Midbrain Rhombomere Fgf8 Gbx2 Cell signalling Regeneration Fig. 6...
Journal Articles