... ©2005. 2005 Midbrain-hindbrain boundary Isthmic organizer Lineage restriction Neuromeres segments Zebrafish Mesencephalon Metencephalon otx2 gbx1 fgf8 The developing central nervous system is compartmentalized at the neural tube stage into discrete units, so-called...

... is required for the initial subdivision of the neuroectoderm,including onset of posterior gbx1 expression and establishment of the posterior border of otx2 expression. Cell transplantation experiments further show that Wnt8 signaling acts directly and non-cell-autonomously. Consistent with these findings...