... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...

... molecular mechanisms necessary for gastrulation and mesenchyme morphogenesis. Wnt signal transduction Anterior-posterior Deuterostome evolution Gene regulatory networks Wnt16 Frizzled National Institutes of Health 10.13039/100000002 15HD088272-01 In metazoans, anterior...

... secretion Wing epithelium Drosophila Fz2 Frizzled Deutsche Forschungsgemeinschaft 10.13039/501100001659 FOR1036 SFB1324 Wnts are lipid-modified secreted proteins conserved in all metazoans and play a pivotal role in development and many diseases ( Nusse and Clevers, 2017 ; Zhan...

..., and resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish...

...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...

... localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Imagine how tricky it would...

...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...

... that the heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse. We identify Ankyrin 2 as a target of Go signaling required for NMJ formation. Moreover, the Go-ankyrin interaction is conserved in the mammalian neurite outgrowth pathway. Without ankyrins, a major switch...

... cortical actin organisation. Morpholino antisense oligonucleotide and mRNA injection studies showed that PCP development requires the Clytia orthologues of the core Fz-PCP pathway components Strabismus (CheStbm), Frizzled (CheFz1) and Dishevelled (CheDsh). Morpholinos targeting any of these components...

... – the Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...

...) Dachsous Fat Frizzled Gradients Starry night (Flamingo) Drosophila Planar cell polarity (PCP) is likely to be a property of all or most epithelial cells, even though they do not always evince it ( Lawrence et al., 2007 ). Some cells reveal their polarity by indicators; examples...

...-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP. * Author for correspondence ( [email protected] ) Competing interests statement 7 1 2010 © 2010. Echinoid Flamingo (Starry night) DE-cadherin (Shotgun) Frizzled Planar cell polarity...

... of dscr5 disrupted Knypek membrane localization and caused an enhanced Frizzled 7 receptor endocytosis in a Caveolin-dependent manner. Furthermore, dscr5 knockdown promoted specific Dishevelled degradation by the ubiquitin-proteosome pathway. These results reveal a functional link between Knypek/Glypican 4...

... localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. * Author for correspondence (e-mail: [email protected] ) 29 7 2008 © 2008. 2008 Planar...

... of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. We demonstrated previously that Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3...

.... This is apparently due, in part, to a loss of regulation of Rho GTPase activity by the planar polarity receptor Frizzled,which itself becomes localised to the migratory edge of the border cells. We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile...

... markedly with their reported role in reintegration of neuroepithelial daughter cells into the neuroepithelial layer after cell division. * Author for correspondence (e-mail: [email protected] ) 28 9 2006 © 2006. 2006 Zebrafish frizzled celsr Facial motor neuron...

.... The other set, the Stan system, encodes Starry night (Stan or Flamingo) and Frizzled. The prevailing view is that the Ds system acts via the Stan system to orient cells. However, using the Drosophila abdomen, we find instead that the two systems operate independently: each confers and propagates polarity...

... is unknown. Here, we report that the Wnt signal is transduced in muscle progenitor cells by at least two Frizzled (Fz)receptors (Fz1 and/or Fz6), through the canonical β-catenin pathway, in the epaxial domain of newly formed somites. We show that Myf5 activation is dramatically reduced by blocking the Wnt/β...

... Four-jointed Dachs Frizzled Grunge Atrophin ft G-rv and ft fd are lethal alleles( Bryant et al., 1988 ). ft clones were generated in y w hs-Flp ; ft G-rv FRT 40A / y + FRT 40A or y w hs-Flp ; ft fd FRT 40A / ubi-GFP FRT 40A larvae. ft 18 ( ft k07918...