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Keywords: frizzled
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Journal Articles
Journal: Development
Development (2020) 147 (19): dev191981.
Published: 5 October 2020
... proteins. Conditional deletion of Wntless or porcupine, both of which are essential for secretion of Wnts, caused misrotated sensory cells and shortened cochlea – both hallmarks of PCP defects. Wntless-deficient cochleae lacked the polarized PCP components dishevelled 1/2 and frizzled 3/6, while other PCP...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... deuterostome embryos strongly suggest that major aspects of the AP Wnt signaling network identified in sea urchin embryos may be conserved among deuterostome embryos ( Range, 2014 ). A combination of the activities of secreted Wnt modulators, trans-membrane Frizzled receptors and co-receptors is necessary...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (24): dev168799.
Published: 16 December 2019
... molecular mechanisms necessary for gastrulation and mesenchyme morphogenesis. Wnt signal transduction Anterior-posterior Deuterostome evolution Gene regulatory networks Wnt16 Frizzled National Institutes of Health 10.13039/100000002 15HD088272-01 In metazoans, anterior...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 9 August 2019
... is regulated by both long-range gradient-dependent and gradient-independent mechanisms. Morphogen gradient formation Wg Wnt Protein secretion Wing epithelium Drosophila Fz2 Frizzled Wnts are lipid-modified secreted proteins conserved in all metazoans and play a pivotal role...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (15): dev174789.
Published: 9 August 2019
... secretion Wing epithelium Drosophila Fz2 Frizzled Deutsche Forschungsgemeinschaft 10.13039/501100001659 FOR1036 SFB1324 Wnts are lipid-modified secreted proteins conserved in all metazoans and play a pivotal role in development and many diseases ( Nusse and Clevers, 2017 ; Zhan...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (8): dev168294.
Published: 29 April 2019
..., and resulted in loss of polarized rosette structures in the aggregates. Mutation in frizzled9b reduced total kidney nephron number, caused defects in tubule morphology and reduced regeneration of new nephrons after injury. Our results demonstrate an essential role for Wnt/frizzled signaling in adult zebrafish...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...
Includes: Supplementary data
Journal Articles
In collection:
Neural development
Journal: Development
Development (2018) 145 (24): dev168666.
Published: 17 December 2018
...Chun-Wei He; Chien-Po Liao; Chung-Kuan Chen; Jérôme Teulière; Chun-Hao Chen; Chun-Liang Pan ABSTRACT Signaling that instructs the migration of neurons needs to be tightly regulated to ensure precise positioning of neurons and subsequent wiring of the neuronal circuits. Wnt-Frizzled signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168229.
Published: 10 December 2018
... work is properly attributed. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Imagine how tricky it would...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev168229.
Published: 10 December 2018
... localised within each cell. Dachsous Fat Four-jointed Frizzled Starry-night Van Gogh ‘ Polarity is in my mind the essential problem. We have to explain why one part of a cell becomes different from another part .’       Sydney Brenner (1994) Imagine how tricky it would...
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 3 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (23): dev169326.
Published: 3 December 2018
...Sergio Garrido-Jimenez; Angel-Carlos Roman; Alberto Alvarez-Barrientos; Jose Maria Carvajal-Gonzalez ABSTRACT In vertebrates, planar polarization of ciliary basal bodies has been associated with actin polymerization that occurs downstream of the Frizzled-planar cell polarity (Fz-PCP) pathway...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2012) 139 (23): 4374–4382.
Published: 1 December 2012
... cortical actin organisation. Morpholino antisense oligonucleotide and mRNA injection studies showed that PCP development requires the Clytia orthologues of the core Fz-PCP pathway components Strabismus (CheStbm), Frizzled (CheFz1) and Dishevelled (CheDsh). Morpholinos targeting any of these components...
Journal Articles
Journal: Development
Development (2011) 138 (13): 2751–2759.
Published: 1 July 2011
... – the Dachsous (Ds) and Frizzled (Fz) systems – play key roles in the establishment and maintenance of such polarity. There has been great progress in uncovering the how these genes work together to produce planar polarity, yet fundamental questions remain unanswered. Here, we study the Drosophila larval ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (20): 3411–3415.
Published: 15 October 2010
...) Dachsous Fat Frizzled Gradients Starry night (Flamingo) Drosophila Planar cell polarity (PCP) is likely to be a property of all or most epithelial cells, even though they do not always evince it ( Lawrence et al., 2007 ). Some cells reveal their polarity by indicators; examples...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (5): 745–754.
Published: 1 March 2010
...-endocytosis of Ed and Fmi provides a link between apicobasal polarity and PCP. Echinoid Flamingo (Starry night) DE-cadherin (Shotgun) Frizzled Planar cell polarity Endocytosis Cell adhesion Adherens junction Drosophila Epithelial cells are polarized cells with different...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal: Development
Development (2008) 135 (18): 3103–3111.
Published: 15 September 2008
... localised core polarity protein Frizzled positively promotes prehair initiation, suggesting that both proximal and distal cellular cues act together to ensure accurate prehair placement. Patches of cells lacking stbm activity present the opposite situation, in which no proximal cue is present...
Includes: Supplementary data
Journal Articles