... in the genome is poorly understood. Here we identified the transcriptomes of Xenopus foregut and hindgut progenitors, which are conserved with mammals. Using RNA-seq and ChIP-seq we show that BMP/Smad1 regulates dorsal-ventral gene expression in both the endoderm and mesoderm, whereas Wnt/β-catenin acts...

... development, key features and estimation of equivalent timeline of mouse development In mouse, the flat sheet of endoderm folds to form the primitive gut tube, which is divided into foregut, midgut and hindgut (Jørgensen et al., 2007 ; Pan and Wright, 2011). The anterior endoderm invaginates to form...

... in specification of mammalian pulmonary progenitors from the ventral foregut endoderm, but their epistatic relationship and downstream targets are largely unknown. In addition, how wnt2 and wnt2b are regulated in the developing foregut mesenchyme is unknown. We show that the Odd-skipped-related (Osr) zinc-finger...

...Eric T. Domyan; Elisabetta Ferretti; Kurt Throckmorton; Yuji Mishina; Silvia K. Nicolis; Xin Sun The mammalian foregut gives rise to the dorsally located esophagus and stomach and the ventrally located trachea and lung. Proper patterning and morphogenesis of the common foregut tube and its derived...

...Laurence Benouaiche; Yorick Gitton; Christine Vincent; Gérard Couly; Giovanni Levi Morphogenesis of the facial skeleton depends on inductive interactions between cephalic neural crest cells and cephalic epithelia, including the foregut endoderm. We show that Shh expression in the most rostral zone...

...Valérie A. McLin; Scott A. Rankin; Aaron M. Zorn The liver and pancreas are specified from the foregut endoderm through an interaction with the adjacent mesoderm. However, the earlier molecular mechanisms that establish the foregut precursors are largely unknown. In this study, we have identified...

...Damon T. Page In vertebrates (deuterostomes), brain patterning depends on signals from adjacent tissues. For example, holoprosencephaly, the most common brain anomaly in humans, results from defects in signaling between the embryonic prechordal plate (consisting of the dorsal foregut endoderm...

... that are defective in the sonic hedgehog (Shh) signaling pathway, and we show that exogenous Shh activates transcription of Foxf1 in developing lung. Foxf1 mRNA is absent in the lungs, foregut and sclerotomes of Shh −/− embryos, but persists in tissues where indian hedgehog (Ihh) is expressed. In lung organ cultures...

... and at the same times as the endogenous Hoxb-1 gene. However, a transgene construct with point mutations in the DR 5 RARE (DR 5 mu) was not expressed in the developing foregut, which gives rise to organs such as the esophagus, lung, stomach, liver and pancreas. Like the wild-type transgene, this DR 5 RARE mutated...

... molecules required for proper development of the foregut, branchial arches and heart. * Author for correspondence (e-mail: [email protected]) 26 05 1997 © 1997 by Company of Biologists 1997 Sonic hedgehog Fgf-8 neural tube patterning forebrain foregut HNF-3 β...

... homo- logues control gsc expression (for BMP4 and Otx-2), or are expressed at the right time and the right place (for XFKH1/Pintallavis and Tlx) to be interacting with gsc during vertebrate development. However, the pattern of D- gsc expression in ectodermal cells of the nervous system and foregut...