... financial interests. 30 12 2013 25 8 2014 © 2014. Published by The Company of Biologists Ltd 2014 Embryo Forebrain patterning Signalling centre Telencephalon Apoptosis Vertebrates Mouse Chick Experimental embryology and genetics have advanced our understanding...

... Forebrain patterning Telencephalon Transcriptional regulation Medaka Vertebrate fate mapping studies have established that the telencephalon, the retinal anlage and the ventral hypothalamus derive from adjacent domains in the anterior neural plate (ANP) ( Sanchez-Arrones et al., 2009...

... provides a unique opportunity to examine the effects of iron deficiency in Fpn1 ffe/ffe and Fpn1 ffe/KI mutants within a crucial range where embryogenesis can proceed but neural tube closure and forebrain patterning are affected. Furthermore, we have found that the degree of malformation is directly...

... UMRS587, Unité de Génétique des Déficits Sensoriels, Collège de France, Institut Pasteur,75015 Paris, France 13 6 2007 © 2007. 2007 Forebrain patterning Thalamus development Zona limitans intrathalamica (ZLI) Hedgehog Zebrafish The regionalisation and refinement...

... expression is independent of Hh signaling, and that gli1 transcription becomes fully activated by Hh signals to mediate its effect on Hh target genes. * Author for correspondence (e-mail: [email protected] ) 14 11 2002 © 2003. 2003 Forebrain patterning Hedgehog signaling...

...Wei Chen; Yuqiong Liang; Wenjie Deng; Ken Shimizu; Amir M. Ashique; En Li; Yi-Ping Li Mouse mutants have allowed us to gain significant insight into axis development. However, much remains to be learned about the cellular and molecular basis of early forebrain patterning. We describe a lethal...

... of hypothalamic cells and for maintenance of medial floor plate and hypothalamic cells. Dorsoventral forebrain patterning is disrupted in smu mutants. Our analysis suggests that diencephalon and telencephalon lose ventral character. Hh signaling leads to induction of genes expressed ventrally, such as nkx...

... at the normal positions in brain structure. Reduction in forebrain pattern is evident by the 12-somite stage, with most neuraxes lacking telencephalon and eyes, while forebrain expressions of the transcription factor genes GANF and BF1 , and of FGF8 , are absent or severely reduced. When the foregut endoderm...

.... Finally, we show that ace expression co-localises with anterior neural plate cells that have previously been shown to have forebrain patterning activity. Removal of these cells leads to a failure in induction of ace expression indicating that loss of Ace activity may contribute to the phenotypes observed...

... and into ventral telencephalon. * The first two authors contributed equally to this work ‡ Author for correspondence (e-mail: [email protected] ) 11 01 1999 03 03 1999 © 1999 by Company of Biologists 1999 Axon guidance Dorsal thalamus Forebrain patterning Globus...

... gene targeting forebrain patterning midbrain patterning hypothalamus pituitary growth regulation oxytocin lactation mammillary bodies Over the past few years there has been much progress in our understanding of the genetic regulation of the early patterning, growth and differentiation...