... and unique expression and function of the six mammalian Dlx family genes. DLX proteins interact with general transcriptional regulators, and co-bind with other transcription factors to enhancer elements with highly specific activity in the developing forebrain. Integration of the genetic and biochemical data...

...Niveda Udaykumar; Mohd Ali Abbas Zaidi; Aishwarya Rai; Jonaki Sen ABSTRACT During embryonic development, the forebrain roof plate undergoes invagination, leading to separation of the cerebral hemispheres. Any defects in this process, in humans, lead to middle interhemispheric holoprosencephaly (MIH...

.... and Parnavelas , J. G. ( 2018 ). Vascular-derived vegfa promotes cortical interneuron migration and proximity to the vasculature in the developing forebrain . Cereb. Cortex   28 , 2577 - 2593 . 10.1093/cercor/bhy082 Bartolini , G. , Sánchez-Alcañiz , J. A. , Osório , C. , Valiente...

... miR-19b as crucial for restricting the expression of Wnt7b to the hem region in chick, where it defines the position of the hem and the hippocampus, revealing its importance in regulating avian forebrain patterning. miR-19b Wnt7b Chick Forebrain Hippocampus Hem The avian...

... Forebrain Mouse National Institutes of Health 10.13039/100000002 EY12162 Incomplete separation of the cerebral hemispheres during embryonic development causes holoprosencephaly (HPE). Depending on its severity, HPE is classified as alobar, semilobar, or lobar, with alobar being...

... character. Thus, Tcf7l1 defines the border between the NC and the prospective forebrain via restriction of the Wnt/β-catenin signaling gradient. The timing of Wnt/β-catenin activation in the head neuroectoderm is crucial. It has been shown in Xenopus that NPB loses its competence for NC induction...

... that Xenopus lpar6 is expressed from late blastulae and is enriched in the mesoderm and dorsal ectoderm of early gastrulae. Expression in gastrulae is an early response to FGF signalling. Transcripts for lpar6 are enriched in the neural plate of Xenopus neurulae and loss of function caused forebrain defects...

... of adjacent genes with shared DNA regulatory elements. * Author for correspondence ( [email protected] ) Competing interests statement The authors declare no competing financial interests. 20 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Forebrain...

.... , Imamoto A. ( 2006 ). Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome . Dev. Cell 10 , 81 – 92 . Halilagic A. , Zile M. H. , Studer M. ( 2003 ). A novel role for retinoids in patterning the avian forebrain during...

... in the chick reveal that this region still produces indistinctly neural, placodal and non-neural derivatives; it does not express neural markers. We examined how the definitive anterior border domain of the rostral forebrain becomes established and comes to display a neural molecular profile, whereas local non...

... that both Noggin proteins, if ectopically produced in sufficient concentrations in Xenopus embryo, can induce a secondary head, including the forebrain. During normal development, however, Noggin1 mRNA is translated in the presumptive forebrain with low efficiency, which provides the sufficient protein...

... ectoderm is required for normal forebrain development. Hesx1 is a conserved vertebrate-specific transcription factor that is required for forebrain development in Xenopus , mice and humans. Mouse embryos deficient for Hesx1 exhibit a variable degree of forebrain defects, but the molecular mechanisms...

... © 2009. 2009 Forebrain FGF receptors Neural plate Neural patterning Mouse How a morphologically uniform sheet of cells becomes patterned into molecularly, functionally and structurally distinct areas remains one of the principal puzzles facing developmental biologists...

...Lara Passante; Nicolas Gaspard; Mélanie Degraeve; Jonas Frisén; Klas Kullander; Viviane De Maertelaer; Pierre Vanderhaeghen Brain structures, whether mature or developing, display a wide diversity of pattern and shape, such as layers, nuclei or segments. The striatum in the mammalian forebrain...

...Alfonso Lavado; Oleg V. Lagutin; Guillermo Oliver The homeobox gene Six3 represses Wnt1 transcription. It is also required in the anterior neural plate for the development of the mammalian rostral forebrain. We have now determined that at the 15- to 17-somite stage, the prospective diencephalon...

...Jae-Yeon Jeong; Zev Einhorn; Priya Mathur; Lishan Chen; Susie Lee; Koichi Kawakami; Su Guo The forebrain constitutes the most anterior part of the central nervous system, and is functionally crucial and structurally conserved in all vertebrates. It includes the dorsally positioned telencephalon...

...Tsutomu Hirata; Masato Nakazawa; Osamu Muraoka; Rika Nakayama; Yoko Suda; Masahiko Hibi Fez and Fez-like ( Fezl ) are zinc-finger genes that encode transcriptional repressors expressed in overlapping domains of the forebrain. By generating Fez;Fezl -deficient mice we found that a redundant function...

...Gang Peng; Monte Westerfield In vertebrate embryos, induction and patterning of the forebrain require the local inhibition of caudalizing signals, such as Wnts, emanating from the mesendoderm and caudal brain. Here, we report that Lhx5, expressed in the rostral neuroectoderm, regulates the local...

...Christian Stigloher; Jovica Ninkovic; Mary Laplante; Andrea Geling; Birgit Tannhäuser; Stefanie Topp; Hiroshi Kikuta; Thomas S. Becker; Corinne Houart; Laure Bally-Cuif Anteroposterior patterning of the vertebrate forebrain during gastrulation involves graded Wnt signaling, which segregates...

... in the forebrain, beginning after rostral neural plate expression of Foxg1 is initiated (∼3 somite stage) ( Shimamura and Rubenstein,1997 ). In principle, reduced Fgf8 expression during gastrulation in non-neural tissues could contribute to the phenotype of the Fgf8 Null/Neo mutants, although we have...