.../progenitor cells. However, the precise stem cell niche organization, the intermediate steps and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive. Quantitative lineage-tracing in vivo revealed that conditional deletion of fibroblast growth factor 10 (Fgf10) from Fgf10-expressing...

... control of Kupffer’s vesicle (KV) cilia length and motility. 3-OST-5 functions in the fibroblast growth factor pathway to control cilia length via the ciliogenic transcription factors FoxJ1a and Rfx2. By contrast, a second 3-OST family member, 3-OST-6, does not regulate cilia length, but regulates cilia...

... that these steps are temporally distinct and that each might require different chemical inputs. To support this, we analyzed the role of fibroblast growth factor (FGF) signaling, in particular the function of two Drosophila FGF ligands, Pyramus and Thisbe, during mesoderm migration. We determined that FGF...

...Tatsuya Sato; Alexandra L. Joyner The isthmic organizer and its key effector molecule, fibroblast growth factor 8 (Fgf8), have been cornerstones in studies of how organizing centers differentially pattern tissues. Studies have implicated different levels of Fgf8 signaling from the mid/hindbrain...

... not impair thyroid development, indicating that other han -expressing structures,most probably cardiac mesoderm, are responsible for the thyroid defects in han mutants. The zebrafish ace ( fgf8 ) mutant has similar thyroid defects as han mutants, and chemical suppression of fibroblast growth factor (FGF...

.... 2004 Lens Wnt signaling Fibroblast growth factors Lens fiber cell differentiation Rat β-crystallin β-catenin The vertebrate ocular lens is composed of two distinctive cell types;differentiated fiber cells that make up the bulk of the lens, and a monolayer of epithelial cells...

...Teri Louise Belecky-Adams; Ruben Adler; David C. Beebe Previous studies showed that the retina produces factors that promote the differentiation of lens fiber cells, and identified members of the fibroblast growth factor (FGF) and insulin-like growth factor (IGF) families as potential fiber cell...

...Craig M. Stolen; Mark W. Jackson; Anne E. Griep ABSTRACT During mammalian embryogenesis, the ocular lens forms through a temporally and spatially regulated pattern of differentiation which is thought to be coordinated at least in part by the FGF-1 and FGF-2 members of the fibroblast growth factor...

... 1996 pattern formation limb initiation axial influence dorsoventral compartments Fibroblast Growth Factors Hoxd genes Sonic Hedgehog Bone Morphogenetic Proteins Wnt-7a C-Lmx1 Engrailed-1 The first indication of the chick wing bud is a condensation of somatopleural...

... fibroblast growth factors activins Gastrulation is a time of extensive morphogenetic movements and in the vertebrate embryo it is also a time of extensive regional specification. The formation of the Xenopus body plan starts with cortical rotation in the egg and mesoderm induction in the blastula...

... advanced state of differentiation, the pigmented epithelium exhibits the same potential as the optic cup in that it can “transdifferentiate” into neural retina. C. M. Park and M. J. Hollenberg (Dev. Biol . 134, 201-205, 1989) discovered that administration of basic fibroblast growth factor, coupled...

...J. M. W. Slack; H. V. Isaacs; B. G. Darlington We have studied the response of Xenopus blastula ectoderm to fibroblast growth factor and to lithium ion. The properties of acidic and basic FGF are very similar showing a 50 % induction level at 1–2 ng ml −1 and a progressive increase of muscle...