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Keywords: fibroblast growth factor
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Journal Articles
Journal: Development
Development (2020) 147 (21): dev189506.
Published: 19 October 2020
... of birth defect and a significant health burden. Despite this, very little is understood about how the ventral body wall is formed. Here, we show that fibroblast growth factor (FGF) ligands FGF8, FGF17 and FGF18 are essential for this process. Conditional mouse mutants for these genes display subtle...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (23): dev185306.
Published: 2 December 2019
...Jakub Sumbal; Zuzana Koledova ABSTRACT Fibroblast growth factor (FGF) signaling is crucial for mammary gland development. Although multiple roles for FGF signaling in the epithelium have been described, the function of FGF signaling in mammary stroma has not been elucidated. In this study, we...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (14): dev177295.
Published: 16 July 2019
... cells not only respond to extrinsic molecular cues and surrounding topology, but can also physically modify the morphogenesis of their tissue substrate. Drosophila melanogaster Caudal visceral mesoderm CVM Trunk visceral mesoderm TVM Fibroblast growth factor FGF Heartless Integrin...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (19): dev166488.
Published: 5 October 2018
.... Clin. North Am.   24 , 427 - 436 . 10.1016/j.fsc.2016.06.002 Chen , L. , Li , D. , Li , C. , Engel , A. and Deng , C.-X. ( 2003 ). A Ser252Trp [corrected] substitution in mouse fibroblast growth factor receptor 2 (Fgfr2) results in craniosynostosis . Bone   33 , 169...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2014) 141 (17): 3352–3362.
Published: 1 September 2014
... 30 6 2014 © 2014. Published by The Company of Biologists Ltd 2014 Fibroblast growth factor Branching morphogenesis Collective epithelial migration Stem cell Mammary gland Breast FGFR2 FGF10 An outstanding question in developmental biology is how different signaling...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (5): 894–905.
Published: 1 March 2012
... poorly understood. The induction of midbrain DA neurons requires sonic hedgehog (Shh) from the floor plate and fibroblast growth factor 8 (FGF8) from the isthmic organizer, but the way in which FGF8 regulates DA neuron development is unclear. We show that, during early embryogenesis, mesodiencephalic...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (13): 2705–2715.
Published: 1 July 2011
...Ivan B. N. Clark; Villö Muha; Anna Klingseisen; Maria Leptin; Hans-Arno J. Müller Fibroblast growth factor (FGF)-dependent epithelial-mesenchymal transitions and cell migration contribute to the establishment of germ layers in vertebrates and other animals, but a comprehensive demonstration...
Includes: Multimedia, Supplementary data
Journal Articles
Journal: Development
Development (2011) 138 (10): 1913–1923.
Published: 15 May 2011
... temporal Shh gradient in specifying vertebrate digit identities . Cell 118 , 517 - 528 . Hernandez-Martinez R. , Castro-Obregon S. , Covarrubias L. ( 2009 ). Progressive interdigital cell death: regulation by the antagonistic interaction between fibroblast growth factor 8...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2010) 137 (22): 3731–3742.
Published: 15 November 2010
...Karel Dorey; Enrique Amaya Fibroblast growth factor (FGF) signalling has been implicated during several phases of early embryogenesis, including the patterning of the embryonic axes, the induction and/or maintenance of several cell lineages and the coordination of morphogenetic movements. Here, we...
Journal Articles
Journal: Development
Development (2009) 136 (14): 2393–2402.
Published: 15 July 2009
...Anna Klingseisen; Ivan B. N. Clark; Tanja Gryzik; H.-Arno J. Müller Thisbe (Ths) and Pyramus (Pyr), two closely related Drosophila homologues of the vertebrate fibroblast growth factor (FGF) 8/17/18 subfamily,are ligands for the FGF receptor Heartless (Htl). Both ligands are required for mesoderm...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (4): 665–676.
Published: 15 February 2009
... and Tannahill, 1992 ),further elaborated by Stern and colleagues( Foley et al., 2000 ; Stern, 2001 ), neural induction produces cells with a rostral forebrain character that, upon the action of`transforming' factors identified as Wnts, fibroblast growth factor (Fgf) and retinoic acid (RA), acquire caudal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3415–3424.
Published: 15 October 2008
... is controlled by sequential molecular and cellular interactions. Fibroblast growth factor (FGF) and Wnt signals emanating from mesoderm and neural ectoderm have been shown to direct inner ear fate. However, the role of these multiple signals during inner ear induction is unclear. We demonstrate that the action...
Journal Articles
Journal: Development
Development (2007) 134 (20): 3615–3625.
Published: 15 October 2007
... for correspondence (e-mail: suzi.mansour@genetics.utah.edu ) 27 7 2007 © 2007. 2007 Fibroblast growth factor Mouse mutant Endolymphatic duct and sac WNT signaling Hearing and balance The inner ear is a morphologically complex sensory organ responsible for hearing and balance...
Journal Articles
Journal: Development
Development (2007) 134 (16): 2969–2979.
Published: 15 August 2007
... failure to selectively induce fibroblast growth factor 10 ( Fgf10 ) in the prospective lung region of the foregut. Little is known about the RA-dependent pathways present in the foregut that may be crucial for lung formation. By performing global gene expression analysis of RA-deficient foreguts from...
Journal Articles
Journal: Development
Development (2006) 133 (23): 4667–4678.
Published: 1 December 2006
... for BMP signaling in multiple aspects of chondrogenesis. They also demonstrate that the balance between signaling outputs from BMP and fibroblast growth factor (FGF) pathways plays a crucial role in the growth plate. These studies indicate that BMP signaling is required to promote Ihh expression...
Journal Articles
Journal: Development
Development (2006) 133 (23): 4709–4719.
Published: 1 December 2006
...Takashi Shimizu; Young-Ki Bae; Masahiko Hibi Fibroblast growth factor (Fgf) and retinoic acid (RA) signals control the formation and anteroposterior patterning of posterior hindbrain. They are also involved in development processes in other regions of the embryo. Therefore,responsiveness to Fgf...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (23): 5173–5183.
Published: 1 December 2005
... ). The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regeneration. Dev. Cell 3 , 547 -555. D'Jamoos, C. A., McMahon, G. and Tsonis, P. A. ( 1998 ). Fibroblast growth factor receptors regulate the ability for hindlimb regeneration in Xenopus laevis. Wound Repair...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (16): 3777–3786.
Published: 15 August 2005
..., and that Ndst1 is a modifier of heparan sulfate-dependent growth factor/morphogen signalling in those tissues. Among the multiple heparan sulfate-binding factors potentially affected in Ndst1 mutant embryos, the facial phenotypes are consistent with impaired sonic hedgehog (Shh) and fibroblast growth factor(Fgf...
Journal Articles
Journal: Development
Development (2005) 132 (2): 371–382.
Published: 15 January 2005
... placode Genetic network Paired Fibroblast growth factor forkhead distal-less msxC Pax proteins are key regulators of developmental processes including specification, differentiation, growth, survival, migration and morphogenesis( Chi and Epstein, 2002 ; Dahl et al., 1997 ; Mansouri...
Journal Articles
Journal: Development
Development (2004) 131 (18): 4511–4520.
Published: 15 September 2004
... and r6 and for activation of Hox group 3 gene expression. Recent work has demonstrated that the expression of val itself depends on three factors: retinoic acid (RA)signals from the paraxial mesoderm; fibroblast growth factor (Fgf) signals from r4; and variant hepatocyte nuclear factor 1 ( vhnf1 ,also...