... (radius and ulna of the forearm, tibia and fibula of the leg) are not well understood, although these bones are susceptible to loss in congenital human syndromes and to the action of teratogens such as thalidomide. Using a new fate-mapping approach with the Chameleon transgenic chicken line, we show...

... for tracing the specific progeny of cells that once expressed a gene of interest in vitro and in vivo ( Sternberg and Hamilton, 1981 ; Sternberg et al., 1981 ; Sauer and Henderson, 1988 ; Orban et al., 1992 ). Lineage-tracing system Fate map Germ layer 2A peptide Site-specific recombinase...

...Iain Martyn; Eric D. Siggia; Ali H. Brivanlou ABSTRACT Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here, we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS...

... reveals that perigonadal fat arises from distinct mesodermal subcompartments in males and females, and that <50% of interscapular brown fat arises from central dermomyotome. Adipocyte Adipose Fate map Lineage tracing Mesoderm National Science Foundation 10.13039/100000001...

... ) and developing brain homeobox 1 ( Dbx1 ). Utilizing simultaneous dual and intersectional fate mapping, we demonstrate that this boundary is precisely formed with minimal overlap between En1 and Dbx1 microdomains, unlike many other boundaries. We show that the En1 microdomain gives rise to dopaminergic (DA...

...Luisa Sanchez-Arrones; Claudio D. Stern; Paola Bovolenta; Luis Puelles The anterior border of the neural plate, presumed to contain the prospective peripheral portion (roof) of the prospective telencephalon, emerges within a vaguely defined proneural ectodermal region. Fate maps carried out at HH4...

..., expression patterns of anterior ectoderm genes overlap significantly and correlate with areas of distinct prospective fates but do not define lineages. The fate map delineates a rostral limit to forebrain contribution. However, no early subdivision of the presumptive forebrain territory can be detected...

... of the invaginating optic cup. We identify unanticipated movements, particularly of central and peripheral retina, RPE and lens. From cell tracking data, we generate retina, RPE and lens subdomain fate maps, which reveal novel adjacencies that might determine corresponding developmental signaling events. Finally, we...

... of tamoxifen. Therefore, the lineage-restriction boundaries revealed by our fate mapping of Gbx2 -expressing cells should apply to cells in the mantle zone as well as those committed progenitors in the ventricular zone of the p2 segment. The prosomeric model proposed by Puelles and Rubenstein has provided...

...), diencephalon (3rd ventricle) and dorsomedial telencephalon bilaterally (lateral ventricles). All of these sites lie at or near the embryonic dorsal midline (DM), which acts as a CNS patterning center. We therefore examined DM-CP relationships using normal and Gdf7 (Bmp12)transgenic embryos to fate map...

... to fate map the oral epithelium in chick embryos, we show that the cells that will occupy the epithelium of the distal and the proximal mandible primordium already occupy different spatial locations in the developing head ectoderm prior to the formation of the first pharyngeal arch and neural crest...

... consisting of two tissue layers, the myocardium and endocardium. The cellular and molecular mechanisms responsible for the separation of ventricular and atrial lineages are not well understood. To test models of cardiac chamber specification, we generated a high-resolution fate map of cardiac chamber...

... of the embryo. The `ml' and`mr' clones maintain their perfect left/right allocation while the `El' and`Er' clones display some left/right mixing (see above). The blastomeres at the eight-cell stage can be depicted as a fate map that predicts where the daughters of the blastomeres end up at the germband( Fig...

... Genetic mosaic Fate map Genetic redundancy Genetic synergy Zebrafish T-box transcription factors are a large family of transcriptional regulators involved in many aspects of embryonic development ( Smith, 1999 ). The founding family member, Brachyury (or T ), was originally identified...

...Alexandria Saulsberry; Paula R. Martin; Tim O’Brien; Leslie E. Sieburth; F. Bryan Pickett Creation of an embryonic fate map may provide insight into the patterns of cell division and specification contributing to the apical region of the early Arabidopsis embryo. A fate map has been constructed...

...Pedro Fernández-Garre; Lucia Rodríguez-Gallardo; Victoria Gallego-Díaz; Ignacio S. Alvarez; Luis Puelles A detailed fate map was obtained for the early chick neural plate (stages 3d/4). Numerous overlapping plug grafts were performed upon New-cultured chick embryos, using fixable...

... of neighboring midline precursors to develop as hypochord, rather than as notochord. *Author for correspondence (e-mail: [email protected] ) 15 3 2002 © 2002. 2002 Delta Notch Notochord Hypochord Midline Fate map Zebrafish Gastrulation During vertebrate development...

... to be the principal mode of cell translocation in the developing cortex ( Rakic, 1988 ). Ganglionic eminences Neocortical development Tangential neuronal migration Ultrasound Fate map Non-pyramidal Interneurons Medium spiny neurons GABA Parvalbumin Somatostatin DARPP-32 Mouse © 2001. 2001...

...Abhay Redkar; Michael Montgomery; Judith Litvin Cardiogenic fate maps are used to address questions on commitment, differentiation, morphogenesis and organogenesis of the heart. Recently, the accuracy of classical cardiogenic fate maps has been questioned, raising concerns about the conclusions...

... 2000 © 2000 by Company of Biologists 2000 distal-less 3 fate map lineage tracing telencephalon In vertebrates, some derivatives of the peripheral nervous system (PNS), including primary sensory neurons of the inner ear and the olfactory epithelium, develop from specialized...