... transcriptomic of embryonic control and SWI/SNF-deficient RPE uncovers RPE-specific gene regulatory networks and their dependence on the SWI/SNF complexes, which further inhibit the neural and cell proliferation genes. RPE SWI/SNF Gene regulatory networks Eye development Mouse Israel Science...

...’ called Pax6 , which is both necessary and sufficient for eye development. Yet precisely how Pax6 achieves this deeply homologous function is poorly understood. Using the chick as a model organism, we show that vertebrate Pax6 interacts with a pair of morphogen-coding genes, Tgfb2 and Fst , to form...

... during Drosophila eye development. Fizzy/Cdc20 controls the early growth of the eye disc anlage and the concomitant entry of glial cells onto the disc. In contrast, fzr/cdh1 acts during neuronal patterning and photoreceptor axon growth, and subsequently affects neuron-glia interaction. To further address...

... regulator of Eya-So in transcriptional outputs that coordinate cell cycle exit with the transition to differentiation during Drosophila retinal development. Eye development Cell cycle Transcription factor Retinal determination gene network Mitotic exit National Institutes of Health...

... a direct interaction between Sipa1l3 and Epha4, building a functional platform for proper ocular development. Epha4 deficiency phenocopied loss of Sipa1l3 and rescue experiments demonstrated that Epha4 acts upstream of Sipa1l3 during eye development, with both Sipa1l3 and Epha4 required for early eye...

... , Y. , Fan , J. , Elcioğlu , N. H. , Toker , E. , Wieland , T. , Maumenee , I. H. , Akarsu , N. A. , Meitinger , T. , Strom , T. M. , et al. ( 2015 ). CRIM1 haploinsufficiency causes defects in eye development in human and mouse . Hum. Mol. Genet.   24 , 2267...

... Yap/Taz and Tead are necessary and sufficient for optic vesicle progenitors to adopt retinal pigmented epithelium identity. Eye development Ocular morphogenesis Zebrafish Tfec Hippo signaling Sveinsson's chorioretinal atrophy Choroid fissure Coloboma Directed differentiation of stem...

... by The Company of Biologists Ltd 2015 Summary: MicroRNAs expressed in the mouse RPE are dispensable for RPE specification and survival but are required for maturation and differentiation of the RPE and adjacent photoreceptors. RPE Dicer1 Dgcr8 MicroRNA Eye development Photoreceptor Mouse...

.... Published by The Company of Biologists Ltd 2013 EGFR signaling ETS proteins Pointed MAP kinase Eye development Development of all multicellular organisms is dictated by a handful of signaling pathways that transmit information from the extracellular milieu and neighboring cells...

...Ke Tang; Xin Xie; Joo-In Park; Milan Jamrich; Sophia Tsai; Ming-Jer Tsai Transcriptional networks, which are initiated by secreted proteins, cooperate with each other to orchestrate eye development. The establishment of dorsal/ventral polarity, especially dorsal specification in the optic vesicle...

... to transmitting the physical forces that partly mediate a coordinated morphogenetic process. * Author for correspondence( [email protected] ) 2 9 2009 © 2009. 2009 Cdc42 IRSp53 (Baiap2) Eye development Filopodia Lens development Morphogenesis Mouse A fundamental...

...José Bessa; Maria J. Tavares; Joana Santos; Hiroshi Kikuta; Mary Laplante; Thomas S. Becker; José Luis Gómez-Skarmeta; Fernando Casares During eye development, retinal progenitors are drawn from a multipotent,proliferative cell population. In Drosophila the maintenance of this cell population...

... in the surface ectoderm overlying the optic vesicle, the surrounding mesenchyme and/or presumptive RPE during the initial stages of eye development. During the initial stages of chick eye development the microphthalmia-associated transcription factor( Mitf ), important for RPE development, is expressed...

... required for Xenopus eye development. Kermit 2/XGIPC functions downstream of IGF in eye formation and is required for maintaining IGF-induced AKT activation. A constitutively active PI3 kinase partially rescues the Kermit 2/XGIPC loss-of-function phenotype. Our results provide the first in vivo loss...

... ) * These authors contributed equally to this work 9 11 2005 © 2006. 2006 Retinoids Forebrain development Eye development Neural crest Telencephalon Diencephalon Optic vesicle Pituitary Sonic hedgehog FGF Mouse Aldh1a2 The embryonic forebrain...

... signaling during early eye development and to study the response of genes with restricted expression along the retinal axes at the 28 hour stage. Of the genes that are restrictively expressed along the NT axis we analyzed the forkhead-transcription factor foxg1 ( BF1 ), which is expressed in the nasal...

... for correspondence (e-mail: [email protected] ) 14 9 2004 © 2004. 2004 spalt seven-up Drosophila Planar cell polarity Eye development Planar cell polarity (PCP), also known as tissue polarity, occurs when epithelial cells are polarized along the plane...

... together, these observations suggest that, during eye development, Pax2 and Pax6 initially function redundantly in the OV during the determination and patterning of the RPE, NR and, possibly,optic-stalk-progenitor domains. During later stages, a switch appears to occur that brings out the distinct...

...Chuen-Chuen Jang; Ju-Lan Chao; Nikolas Jones; Li-Chin Yao; Dmitri A. Bessarab; Yien M. Kuo; Susie Jun; Claude Desplan; Steven K. Beckendorf; Y. Henry Sun We report the identification of a Drosophila Pax gene, eye gone ( eyg ), which is required for eye development. Loss-of-function eyg mutations...

...Matthias Carl; Felix Loosli; Joachim Wittbrodt The establishment of retinal identity and the subsequent patterning of the optic vesicle are the key steps in early vertebrate eye development. To date little is known about the nature and interaction of the genes controlling these steps. So far few...