... changes are the quasi-exclusive contributors to inter-morph variations in gene expression. Among a list of 108 genes with change at the cis -regulatory level, we explored the control of expression of rx3 , which is a master eye gene. We discovered that cellular rx3 levels are cis- regulated in a cell...

...Manabu Kitamata; Yoshiaki Otake; Hideaki Kitagori; Xuanshuo Zhang; Yusuke Maki; Rika Boku; Masato Takeuchi; Hideki Nakagoshi ABSTRACT Vision is mainly based on two different tasks, object detection and color discrimination, carried out by photoreceptor (PR) cells. The Drosophila compound eye...

... be redirected when discs regenerate after injury or when key selector genes are misregulated. Here, we show that when Polycomb expression is reduced, the wing selector gene vestigial is ectopically activated. This leads to the inappropriate formation of the Vestigial–Scalloped complex, which forces the eye...

... in the concentrations of transcription factors and therefore large differences in their stoichiometric ratios. Whether cells can elicit transitions using modest changes in the ratios of co-expressed factors is unclear. Here, we investigate how cells in the Drosophila eye resolve state transitions by quantifying...

...Shuyi Mai; Xiaoxuan Zhu; Esther Yi Ching Wan; Shengyu Wu; Jesslyn Nagalin Yonathan; Jun Wang; Ying Li; Jessica Yuen Wuen Ma; Bing Zuo; Dennis Yan-yin Tse; Pui-Chi Lo; Xin Wang; Kui Ming Chan; David M. Wu; Wenjun Xiong ABSTRACT Eye size is a key parameter of visual function, but the precise...

...Donald F. Ready; Henry C. Chang ABSTRACT Actomyosin contraction shapes the Drosophila eye's panoramic view. The convex curvature of the retinal epithelium, organized in ∼800 close-packed ommatidia, depends upon a fourfold condensation of the retinal floor mediated by contraction of actin stress...

.... Comparison with mice deficient for integrase interactor 1 ( Ini1 , also known as Smarcb1 ) revealed that the enlarged NR was Brg1 specific and was not caused by a general dysfunction of the SWI/SNF complex. These results suggest a crucial role for Brg1 in NSCs during brain and eye development. Brg1 loss...

...Kristen M. Koenig; Jeffrey M. Gross ABSTRACT For centuries, the eye has fascinated scientists and philosophers alike, and as a result the visual system has always been at the forefront of integrating cutting-edge technology in research. We are again at a turning point at which technical advances...

...Chase D. Bryan; Macaulie A. Casey; Rebecca L. Pfeiffer; Bryan W. Jones; Kristen M. Kwan ABSTRACT Organogenesis requires precise interactions between a developing tissue and its environment. In vertebrates, the developing eye is surrounded by a complex extracellular matrix as well as multiple...

... unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Summary: Multidimensional imaging of ptch2 mutant zebrafish uncovers a role for the Hh signaling pathway in regulating the cell and tissue dynamics underlying early eye morphogenesis...

...Luke R. Baker; Bonnie M. Weasner; Athena Nagel; Sarah D. Neuman; Arash Bashirullah; Justin P. Kumar ABSTRACT The transcription factor Pax6 is considered the master control gene for eye formation because (1) it is present within the genomes and retina/lens of all animals with a visual system; (2...

... urchins and frogs. Here, we demonstrate that Polycomb group (PcG) proteins maintain Drosophila eye specification by suppressing the activation of alternative fate choices. The loss of PcG in the developing eye results in a cellular reprogramming event in which the eye is redirected to a wing fate...

...Tanushree Pandit; Vijay K. Jidigam; Cedric Patthey; Lena Gunhaga The eye has served as a classical model to study cell specification and tissue induction for over a century. Nevertheless, the molecular mechanisms that regulate the induction and maintenance of eye-field cells, and the specification...

... to obtain directional and positional information. Within the Drosophila retina, D/V axis formation is essential to ensure that each unit eye first adopts the proper chiral form and then rotates precisely 90° in the correct direction. These two steps are important because the photoreceptor array must...

... have shown that Drosophila integrins form adhesion complexes with Integrin-linked kinase and talin in the peripheral nerve glia and have conserved roles in glial sheath formation. However, integrin function in other aspects of glial development is unclear. The Drosophila eye imaginal disc (ED...

..., in the developing eye. In this tissue, the Dpp expression domain advances from the posterior to the anterior tissue edge. In front of this moving morphogen source, signaling inputs including Dpp activate the target gene hairy in a gradient that scales with tissue size. Proliferation, in turn, occurs in a mitotic...

...Jörg Steinfeld; Ichie Steinfeld; Nicola Coronato; Meggi-Lee Hampel; Paul G. Layer; Masasuke Araki; Astrid Vogel-Höpker The retinal pigment epithelium (RPE) is indispensable for vertebrate eye development and vision. In the classical model of optic vesicle patterning, the surface ectoderm produces...

... statement The authors declare no competing financial interests. 9 8 2013 © 2013. Published by The Company of Biologists Ltd 2013 Drosophila R7 Cell fate Eye Lozenge When cells make developmental decisions, two influences can play crucial roles: the external...

...Carrie M. Spratford; Justin P. Kumar The compound eye of Drosophila melanogaster is configured by a differentiating wave, the morphogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiated cells into a precisely ordered repetitive array of 800 ommatidia...

...-posterior polarized responses to wounds, indicating that pbx is required after wound responses for development and maintenance of poles during regeneration and homeostatic tissue turnover. Independently of the requirement for pbx in pole regeneration, pbx is required for eye precursor formation...