... to FA-mediated ECM contact is currently unknown. The basal foot has also been observed in vertebrates, where it has been proposed to act as a cue and ensure divided cells remain in the epithelium after cytokinesis completion ( Guevara-Garcia et al., 2023 ). Further work is required to elucidate...

... in the control of lung morphogenesis. These findings are relevant to lung tumorigenesis, in which a pathological function of Nolz1 is implicated. Hematoxylin and eosin (H&E) stains showed that the mesenchyme and epithelium appeared to be similar between wild-type and KO lungs at E12.5 ( Fig. 2 C). By E14.5...

... , e1004904 . 10.1371/journal.pgen.1004904 Esmangart De Bournonville , T. and Le Borgne , R. ( 2020 ). Interplay between anakonda, gliotactin, and M6 for tricellular junction assembly and anchoring of septate junctions in Drosophila epithelium . Curr. Biol. 30 , 4245 - 4253.e4...

... component of supracellular actomyosin cables during epithelial morphogenesis that serve to insulate morphogenetic changes from each other. Actomyosin Supracellular cable Junctions Cytoskeleton Tension Epithelium Morphogenesis Medical Research Council http://dx.doi.org/10.13039...

.... Development Drosophila Wing Cell junctions Epithelium Exocyst Marie Curie IEF2008 number 237404 Cancer Research UK http://dx.doi.org/10.13039/501100000289 FC001175 Medical Research Council FC001175 Wellcome Trust http://dx.doi.org/10.13039/100010269...

... tissues ( Ehf −/− ) or specifically in the gut epithelium. Ehf −/− mice were born at the expected Mendelian ratio, but showed reduced body weight gain, and developed a series of pathologies requiring most Ehf −/− mice to reach an ethical endpoint before reaching 1 year of age. These included papillomas...

... transcription factors as upstream regulators of Wnt5a in the 4V ChP epithelium. * Authors for correspondence ( [email protected] ; [email protected] ) Handling Editor: Paola Arlotta Competing interests The authors declare no competing or financial interests. 23...

... markers associated with EMT. EMT MET Cancer metastasis Developmental models Epithelium Mesenchyme Epithelial-mesenchymal transition (EMT) and its reverse process mesenchymal-epithelial transition (MET) are dynamic processes – collectively referred to as EMTs – that are associated...

... of the head. In the eye and ear, these neural crest cells then transform back into an epithelium, via mesenchymal-to-epithelial transition (MET), highlighting the flexibility of this population. Elsewhere in the head, the epithelium loses its integrity and transforms into mesenchyme. Here, we review...

..., by contrast, did not reveal overt changes in early patterning of the distal progenitor epithelial tree. Instead, we did observe late defects in cellular morphology, as the transition from columnar to squamous epithelium during terminal differentiation is impaired in the absence of Cyp26b1. This suggests...

.... Summary: Reduction of the adherens junction component β-catenin is a crucial mechanism for regulating the cell-cell interactions that ensure rapid epidermal wound closure in Drosophila larvae. Wound repair Adherens junctions Epithelium Casein kinase 1α β-Catenin Drosophila...

... into the IFE to regenerate the epidermis and, vice versa, IFE stem cells can generate hair follicles upon transplantation. Although experimental evidence for many dedifferentiation events is compelling (solid arrows) for others it is preliminary (broken arrows). (C) In the lung proximal airway epithelium...

... at parasegmental boundaries, and suppresses epithelial folding along these boundaries, where Hedgehog signalling has opposing effects. Apico-basal polarity Contractility Embryo Epithelium Morphogenesis Planar polarity Biotechnology and Biological Sciences Research Council 10.13039/501100000268...

... the equator. To elucidate the mechanisms underlying lens epithelial cell movement, we conducted time-lapse imaging of zebrafish lens epithelium. Lens epithelial cells do not intermingle but maintain their relative positions during development. Cell division induces epithelial rearrangement, which subsequently...

...Katsumi Fumoto; Hisako Takigawa-Imamura; Kenta Sumiyama; Tomoyuki Kaneiwa; Akira Kikuchi In lung development, the apically constricted columnar epithelium forms numerous buds during the pseudoglandular stage. Subsequently, these epithelial cells change shape into the flat or cuboidal pneumocytes...

... by severe ciliopathies, such as Meckel syndrome, present several ocular surface disease conditions of unclear pathogenesis. Here, we show that primary cilia are predominantly present on basal cells of the mouse corneal epithelium (CE) throughout development and in the adult. Conditional ablation of cilia...

... BMP-Smad1/5 signaling and associated endothelial cells are required for reorganization of the thyroid progenitor cell mass into mature follicles via the assembly of a basement membrane. Thyroid Smad1 Smad5 Follicle Epithelium Extracellular matrix Mouse Thyroid follicles...

... in epithelia. We have studied the role of spectrins during epithelia morphogenesis using the Drosophila follicular epithelium (FE). As previously described, we show that α-Spectrin and β-Spectrin are essential to maintain a monolayered FE, but, contrary to previous work, spectrins are not required to control...

.... Inductive interactions between epithelium and mesenchyme regulate gut development, but the influence of these interactions on ENS development is unknown. Epithelial-mesenchymal recombinations were constructed using avian hindgut mesenchyme and non-intestinal epithelium from the bursa of Fabricius...

... understood. The embryonic pancreas, which gives rise to β-cells, undergoes early epithelial rearrangements, including transient stratification of an initially monolayered epithelium, followed by microlumen formation and later resolution into branches. Within the epithelium, a multipotent progenitor cell (MPC...