... importantly, we found that miR-452 was the most enriched miRNA in early NCCs and regulated epithelial-mesenchymal interactions in the mandibular region of PA1 by directly targeting Wnt5a in the NCC-derived mesenchyme. Our findings suggest that miR-452 negatively regulates secretion of Wnt5a from the NCC...

... for correspondence (e-mail: [email protected] ) 31 3 2009 © 2009. 2009 Sox2 Foregut development Trachea Epithelial-mesenchymal interaction Epithelial differentiation Injury-repair Mouse The anterior foregut of the mammalian embryo initially consists of a simple epithelial...

... and mesenchymal compartments during key steps in the genesis of some organs. This selective expression suggests a role in epithelial-mesenchymal interactions. Importantly, using the developing metanephros as a model system, we have observed that endogenously expressed and exogenously supplemented Sema4d inhibits...

... 201203 28 7 2005 ©2005. 2005 Mouse Cleft palate Shox2 Epithelial-mesenchymal interaction The mammalian palate forms by the union of the primary palate and the two secondary palatal shelves. In mice, the development of the secondary palate initiates at embryonic day 11.5...

... Differentiation Epithelial-mesenchymal interaction Mouse Despite the wealth of knowledge about the origin and differentiation of lung epithelial cells, extremely little is known about the origin and differentiation of the various lung mesenchymal cell types, i.e. the parabronchial and alveolar smooth...

... novel differentiation products, potential effectors of epithelial-mesenchymal interactions, and candidate markers and regulators of intestinal epithelium. Transcripts that decline significantly during intestine development frequently are absent from the adult gut. We show that a significant proportion...

... reciprocal epithelial-mesenchymal signaling. Several growth and differentiation factors have been implicated in these processes but the mechanisms by which GI epithelial-mesenchymal interactions proceed in vivo are still poorly understood. Here we show that PDGF-A is necessary for the normal development...

... Discussion). Organogenesis has been assumed to include several fundamental processes: firstly, the initiation of organ formation by inducing organ outgrowth, and, secondly, subsequent tissue differentiation through various mechanisms e.g. epithelial- mesenchymal interactions ( Hogan, 1999...

... anteroposteriorly into various organs such as the esophagus, stomach (proventriculus and gizzard in the chicken), duodenum, small intestine and large intestine. Differentiation along the anterior-posterior (AP) axis has been extensively studied and the importance of epithelial-mesenchymal interactions...

...-mail: [email protected] ) 02 06 1999 19 07 1999 © 1999 by Company of Biologists 1999 Androgen receptor Tenascin C Epithelial-mesenchymal interaction Apoptosis PTH/PTHrP receptor Mouse The development of many epithelial organs depends on a series of sequential and reciprocal...

... papilla Platelet-derived growth factor Sonic hedgehog Epithelial-mesenchymal interaction The development of many epithelial organs involves conserved patterns of inductive and permissive signaling between epithelial and mesenchymal tissues ( Thesleff and Sahlberg, 1996 ), and in the mature...

... in the chick embryo to further elucidate the roles of these factors in the epithelial-mesenchymal interactions which guide the regionalization of the gut. Although Shh conveys region-specific positional information, as in the specification of the pancreas, we find that the visceral mesoderm already possesses...

... 1998 26 02 1998 © 1998 by Company of Biologists 1998 Epithelial-mesenchymal interaction Branching morphogenesis Ectodermal dysplasia Genetic rescue Keratin 14 Organogenesis PTH/PTHrP receptor Mammary mesenchyme Parathyroid hormone-related peptide (PTHrP) was initially...

... dental epithelia. As Bmp-4 is expressed only in the underlying dental mesenchyme at the onset of the enamel knot formation, these results support the role of the cyclin-dependent kinase inhibitors as inducible cell differentiation factors in epithelial-mesenchymal interactions. Furthermore, we show...

.... and Kinbara , H. ( 1992 ). Role of epithelial-mesenchymal interactions in the differentiation and spatial organization of visceral smooth muscle Epith . Cell Biol . 1 , 76 – 83 . Donjacour , A. A. and Cunha , G. R. ( 1993 ). Assessment of prostatic protein secretion in tissue...

... targeting heart defect skeletal defect epithelial-mesenchymal interaction mouse knockout TGFβ2 is a member of the highly conserved TGFβ super gene family that consists of more than thirty ligand proteins (reviewed by Kingsley, 1994 ). Members of this family represent structurally similar, yet...

[email protected] ) 28 02 1997 © 1997 by Company of Biologists 1997 FGF10 lateral plate mesoderm limb initiation FGF8 epithelial-mesenchymal interaction Among the FGF members identified so far, FGF10 exhibits the highest amino acid sequence identity to FGF7 (See Materials...

...Yuichi Kadoya; Katriina Salmivirta; Jan Fredrik Talts; Kuniko Kadoya; Ulrike Mayer; Rupert Timpl; Peter Ekblom ABSTRACT Epithelial-mesenchymal interactions are major driving forces for the development of most solid organs. The importance of these interactions was first shown for the embryonic...

...-mail [email protected] ) 17 07 1996 © 1996 by Company of Biologists 1996 BMP4 epithelial-mesenchymal interaction homeobox gene inductive signalling knockout mice Msx1 tooth development Inductive tissue interactions between apposed epithelial and mesenchymal...

... epithelial-mesenchymal interactions is impaired in LEF-1deficient mice . Genes Dev . 8 , 2691 – 2703 . 10.1101/gad.8.22.2691 Weir , E. C. , Insogna , K. L. , Brownstein , D. G. , Bander , N. and Broadus , A. E. ( 1988 ). In vitro adenylate cyclase-stimulating activity...