...-mesenchymal interaction. Of course, miR-452 and other NCC-enriched miRNAs are likely to target other mRNAs in the NCC-derived mesenchyme of PA1 that further regulate the epithelial-mesenchymal interactions required for proper PA development. We investigated whether miR-452 promotes Dlx2 expression...

...-mail: [email protected] ) 31 3 2009 © 2009. 2009 Sox2 Foregut development Trachea Epithelial-mesenchymal interaction Epithelial differentiation Injury-repair Mouse The anterior foregut of the mammalian embryo initially consists of a simple epithelial tube surrounded...

... and mesenchymal compartments during key steps in the genesis of some organs. This selective expression suggests a role in epithelial-mesenchymal interactions. Importantly, using the developing metanephros as a model system, we have observed that endogenously expressed and exogenously supplemented Sema4d inhibits...

... of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127 , 1671 -1679. Chen, Y. P. and Maas, R. ( 1998 ). Signaling loops in the reciprocal epithelial-mesenchymal interactions of mammalian tooth development. In Molecular basis of epithelial appendage morphogenesis...

... muscle cells Lung Progenitors Differentiation Epithelial-mesenchymal interaction Mouse Despite the wealth of knowledge about the origin and differentiation of lung epithelial cells, extremely little is known about the origin and differentiation of the various lung mesenchymal cell types, i.e...

... novel differentiation products, potential effectors of epithelial-mesenchymal interactions, and candidate markers and regulators of intestinal epithelium. Transcripts that decline significantly during intestine development frequently are absent from the adult gut. We show that a significant proportion...

... of the GI-tract. Our study also reveals key events in the morphogenesis of GI villi and highlights villus formation as a useful model system for the study of epithelial-mesenchymal interaction. Together with the previously established roles for PDGF-A in the formation of lung alveoli and PDGF-B in kidney...

... Discussion). Organogenesis has been assumed to include several fundamental processes: firstly, the initiation of organ formation by inducing organ outgrowth, and, secondly, subsequent tissue differentiation through various mechanisms e.g. epithelial- mesenchymal interactions ( Hogan, 1999...

... anteroposteriorly into various organs such as the esophagus, stomach (proventriculus and gizzard in the chicken), duodenum, small intestine and large intestine. Differentiation along the anterior-posterior (AP) axis has been extensively studied and the importance of epithelial-mesenchymal interactions...

... phenotype. * Author for correspondence (e-mail: [email protected] ) 02 06 1999 19 07 1999 © 1999 by Company of Biologists 1999 Androgen receptor Tenascin C Epithelial-mesenchymal interaction Apoptosis PTH/PTHrP receptor Mouse The development of many...

... Development Dermal papilla Platelet-derived growth factor Sonic hedgehog Epithelial-mesenchymal interaction The development of many epithelial organs involves conserved patterns of inductive and permissive signaling between epithelial and mesenchymal tissues ( Thesleff and Sahlberg, 1996...

... on epithelial-mesenchymal interactions . J. Cell Biol. 107 , 2341 – 2349 . 10.1083/jcb.107.6.2341 Bancroft , J.D. and Stevens , A. ( 1990 ). Theory and Practice of Histotechnology . Churchill Livingstone . Basler , K. , Edlund , T. , Jessell , T.M. and Yamada , T...

...-G. , Parslow , T. G. , Bruhn , L. and Grosschedl , R. ( 1994 ). Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice . Genes Dev . 8 . 2691 – 2703 . 10.1101/gad.8.22.2691 Vortkamp , A. , Lee...

... dental epithelia. As Bmp-4 is expressed only in the underlying dental mesenchyme at the onset of the enamel knot formation, these results support the role of the cyclin-dependent kinase inhibitors as inducible cell differentiation factors in epithelial-mesenchymal interactions. Furthermore, we show...

... 1997 © 1997 by Company of Biologists 1997 hyaluronan CD44 prostate development branching morphogenesis mouse epithelial-mesenchymal interaction Hyaluronan (HA) is a large polysaccharide in the extracellular matrix (ECM) with the repeating disaccharide unit of D-glucuronic...

... support a role for TGFβ2 in both of these chondrogenic pathways. Numerous epithelial-mesenchymal interactions take place during normal eye development (reviewed in Tripathi et al., 1991 ; Barishak, 1992 ). TGFβ2 expression has been found in several regions of the eye ( Pasquale et al., 1993...

[email protected] ) 28 02 1997 © 1997 by Company of Biologists 1997 FGF10 lateral plate mesoderm limb initiation FGF8 epithelial-mesenchymal interaction The chick limb stands as an ideal model system to elucidate the mechanisms that coordinate growth and patterning during...

...Yuichi Kadoya; Katriina Salmivirta; Jan Fredrik Talts; Kuniko Kadoya; Ulrike Mayer; Rupert Timpl; Peter Ekblom ABSTRACT Epithelial-mesenchymal interactions are major driving forces for the development of most solid organs. The importance of these interactions was first shown for the embryonic...

... dorsal-ventral patterning of somites . Cell 79 , 1165 – 1173 . 10.1016/0092-8674(94)90008-6 Jowett , A. K. , Vainio , S. , Ferguson , M. W. , Sharpe , P. T. and Thesleff , I. ( 1993 ). Epithelial-mesenchymal interactions are required for msx1 and msx2 gene...

... 1995 by Company of Biologists 1995 epithelial-mesenchymal interaction organogenesis calciotropic hormones myoepithelial cells PTH/PTHrP receptor transgenic mice Parathyroid hormone-related protein (PTHrP) was originally discovered as the tumor product that is responsible for most...